Radiation interaction with DNA

• Autor(a) principal: Deppman,A.
• Data de Publicação: 2004
• Outros Autores: Echeimberg,J.O., Gouveia,A.N., Arruda-Neto,J.D.T., Milian,F.M., Added,N., Camargo,M.E., Guzman,F., Helene,O.A.M., Likhachev,V.P., Rodriguez,O., Schenberg,A.C.G., Vanin,V., Vicente,E.J.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Physics
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-97332004000500068

We developed a model to describe the radiation-DNA interaction in water solution. The model is based on some important aspects of the Bethe Theory for the ionizing process, and on the assumption that the direct interaction between the incident particle and the DNA molecule is negligible in comparison with the indirect effect. This assumption can always be true under controlled conditions. The results show that the number of damages induced by radiation depends on the accumulated dose, on parameters related only to the medium properties, and on the DNA structure, but not on the incident particle. A few applications of the model are discussed, and results are successfully compared with experimental data. New experiments are proposed.