Genetic and audiologic study in elderly with sensorineural hearing loss

Detalhes bibliográficos
Autor(a) principal: Martins,Kelly
Data de Publicação: 2013
Outros Autores: Fontenele,Marília, Câmara,Silva, Sartorato,Edi Lúcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: CoDAS
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822013000300006
Resumo: PURPOSE: This study aimed to correlate probable predisposing factors for sensorineural hearing loss in elderly by investigating the audiologic characteristics and frequency of mutations in genes considered responsible for non-syndromic hearing loss. METHODS: Sixty elderly patients were separated into two groups: the Case Group, composed of 30 individuals, 21 females and nine males, all 60 years old or older and presenting diagnoses of sensorineural hearing loss, and the Control Group, composed of 30 elderly individuals matched to the experimental group by age and gender, presenting normal hearing. The patients underwent anamnesis and pure tone audiometry in frequencies of 250, 500, 1000, 2000, 3000, 4000 and 6000 Hz. Blood samples were collected from each patient for analysis of mutations in nuclear and mitochondrial genes related to non-syndromic sensorineural hearing loss. RESULTS: It was observed a greater tendency to noise exposure and consumption of alcohol in the Case Group. The statistically significant symptoms between the groups were tinnitus and hearing difficulty in several situations as: silent environment, telephone, television, sound location and in church. All the individuals of Case Group presented sensorineural and bilateral hearing loss. The symmetry and progression of the hearing impairment were also statistically significant between the groups. No genetic mutations were identified. CONCLUSION: The most reported symptoms were communication difficulties and tinnitus. The predominant auditory characteristics included sensorineural, bilateral, progressive and symmetrical hearing loss. It was not evidenced a relationship between sensorineural hearing loss in elderly and genes considered responsible for non-syndromic hearing loss as no genetic mutation was found in this study.
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spelling Genetic and audiologic study in elderly with sensorineural hearing lossHearing lossAgedPresbycusisDeafnessGeneticsPURPOSE: This study aimed to correlate probable predisposing factors for sensorineural hearing loss in elderly by investigating the audiologic characteristics and frequency of mutations in genes considered responsible for non-syndromic hearing loss. METHODS: Sixty elderly patients were separated into two groups: the Case Group, composed of 30 individuals, 21 females and nine males, all 60 years old or older and presenting diagnoses of sensorineural hearing loss, and the Control Group, composed of 30 elderly individuals matched to the experimental group by age and gender, presenting normal hearing. The patients underwent anamnesis and pure tone audiometry in frequencies of 250, 500, 1000, 2000, 3000, 4000 and 6000 Hz. Blood samples were collected from each patient for analysis of mutations in nuclear and mitochondrial genes related to non-syndromic sensorineural hearing loss. RESULTS: It was observed a greater tendency to noise exposure and consumption of alcohol in the Case Group. The statistically significant symptoms between the groups were tinnitus and hearing difficulty in several situations as: silent environment, telephone, television, sound location and in church. All the individuals of Case Group presented sensorineural and bilateral hearing loss. The symmetry and progression of the hearing impairment were also statistically significant between the groups. No genetic mutations were identified. CONCLUSION: The most reported symptoms were communication difficulties and tinnitus. The predominant auditory characteristics included sensorineural, bilateral, progressive and symmetrical hearing loss. It was not evidenced a relationship between sensorineural hearing loss in elderly and genes considered responsible for non-syndromic hearing loss as no genetic mutation was found in this study.Sociedade Brasileira de Fonoaudiologia2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822013000300006CoDAS v.25 n.3 2013reponame:CoDASinstname:Sociedade Brasileira de Fonoaudiologia (SBFA)instacron:SBFA10.1590/S2317-17822013000300006info:eu-repo/semantics/openAccessMartins,KellyFontenele,MaríliaCâmara,SilvaSartorato,Edi Lúciaeng2013-07-19T00:00:00Zoai:scielo:S2317-17822013000300006Revistahttps://www.codas.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.phpcodas@editoracubo.com.br||revista@codas.org.br2317-17822317-1782opendoar:2013-07-19T00:00CoDAS - Sociedade Brasileira de Fonoaudiologia (SBFA)false
dc.title.none.fl_str_mv Genetic and audiologic study in elderly with sensorineural hearing loss
title Genetic and audiologic study in elderly with sensorineural hearing loss
spellingShingle Genetic and audiologic study in elderly with sensorineural hearing loss
Martins,Kelly
Hearing loss
Aged
Presbycusis
Deafness
Genetics
title_short Genetic and audiologic study in elderly with sensorineural hearing loss
title_full Genetic and audiologic study in elderly with sensorineural hearing loss
title_fullStr Genetic and audiologic study in elderly with sensorineural hearing loss
title_full_unstemmed Genetic and audiologic study in elderly with sensorineural hearing loss
title_sort Genetic and audiologic study in elderly with sensorineural hearing loss
author Martins,Kelly
author_facet Martins,Kelly
Fontenele,Marília
Câmara,Silva
Sartorato,Edi Lúcia
author_role author
author2 Fontenele,Marília
Câmara,Silva
Sartorato,Edi Lúcia
author2_role author
author
author
dc.contributor.author.fl_str_mv Martins,Kelly
Fontenele,Marília
Câmara,Silva
Sartorato,Edi Lúcia
dc.subject.por.fl_str_mv Hearing loss
Aged
Presbycusis
Deafness
Genetics
topic Hearing loss
Aged
Presbycusis
Deafness
Genetics
description PURPOSE: This study aimed to correlate probable predisposing factors for sensorineural hearing loss in elderly by investigating the audiologic characteristics and frequency of mutations in genes considered responsible for non-syndromic hearing loss. METHODS: Sixty elderly patients were separated into two groups: the Case Group, composed of 30 individuals, 21 females and nine males, all 60 years old or older and presenting diagnoses of sensorineural hearing loss, and the Control Group, composed of 30 elderly individuals matched to the experimental group by age and gender, presenting normal hearing. The patients underwent anamnesis and pure tone audiometry in frequencies of 250, 500, 1000, 2000, 3000, 4000 and 6000 Hz. Blood samples were collected from each patient for analysis of mutations in nuclear and mitochondrial genes related to non-syndromic sensorineural hearing loss. RESULTS: It was observed a greater tendency to noise exposure and consumption of alcohol in the Case Group. The statistically significant symptoms between the groups were tinnitus and hearing difficulty in several situations as: silent environment, telephone, television, sound location and in church. All the individuals of Case Group presented sensorineural and bilateral hearing loss. The symmetry and progression of the hearing impairment were also statistically significant between the groups. No genetic mutations were identified. CONCLUSION: The most reported symptoms were communication difficulties and tinnitus. The predominant auditory characteristics included sensorineural, bilateral, progressive and symmetrical hearing loss. It was not evidenced a relationship between sensorineural hearing loss in elderly and genes considered responsible for non-syndromic hearing loss as no genetic mutation was found in this study.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822013000300006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822013000300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S2317-17822013000300006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Fonoaudiologia
publisher.none.fl_str_mv Sociedade Brasileira de Fonoaudiologia
dc.source.none.fl_str_mv CoDAS v.25 n.3 2013
reponame:CoDAS
instname:Sociedade Brasileira de Fonoaudiologia (SBFA)
instacron:SBFA
instname_str Sociedade Brasileira de Fonoaudiologia (SBFA)
instacron_str SBFA
institution SBFA
reponame_str CoDAS
collection CoDAS
repository.name.fl_str_mv CoDAS - Sociedade Brasileira de Fonoaudiologia (SBFA)
repository.mail.fl_str_mv codas@editoracubo.com.br||revista@codas.org.br
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