Genetic and audiologic study in elderly with sensorineural hearing loss
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | CoDAS |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822013000300006 |
Resumo: | PURPOSE: This study aimed to correlate probable predisposing factors for sensorineural hearing loss in elderly by investigating the audiologic characteristics and frequency of mutations in genes considered responsible for non-syndromic hearing loss. METHODS: Sixty elderly patients were separated into two groups: the Case Group, composed of 30 individuals, 21 females and nine males, all 60 years old or older and presenting diagnoses of sensorineural hearing loss, and the Control Group, composed of 30 elderly individuals matched to the experimental group by age and gender, presenting normal hearing. The patients underwent anamnesis and pure tone audiometry in frequencies of 250, 500, 1000, 2000, 3000, 4000 and 6000 Hz. Blood samples were collected from each patient for analysis of mutations in nuclear and mitochondrial genes related to non-syndromic sensorineural hearing loss. RESULTS: It was observed a greater tendency to noise exposure and consumption of alcohol in the Case Group. The statistically significant symptoms between the groups were tinnitus and hearing difficulty in several situations as: silent environment, telephone, television, sound location and in church. All the individuals of Case Group presented sensorineural and bilateral hearing loss. The symmetry and progression of the hearing impairment were also statistically significant between the groups. No genetic mutations were identified. CONCLUSION: The most reported symptoms were communication difficulties and tinnitus. The predominant auditory characteristics included sensorineural, bilateral, progressive and symmetrical hearing loss. It was not evidenced a relationship between sensorineural hearing loss in elderly and genes considered responsible for non-syndromic hearing loss as no genetic mutation was found in this study. |
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Genetic and audiologic study in elderly with sensorineural hearing lossHearing lossAgedPresbycusisDeafnessGeneticsPURPOSE: This study aimed to correlate probable predisposing factors for sensorineural hearing loss in elderly by investigating the audiologic characteristics and frequency of mutations in genes considered responsible for non-syndromic hearing loss. METHODS: Sixty elderly patients were separated into two groups: the Case Group, composed of 30 individuals, 21 females and nine males, all 60 years old or older and presenting diagnoses of sensorineural hearing loss, and the Control Group, composed of 30 elderly individuals matched to the experimental group by age and gender, presenting normal hearing. The patients underwent anamnesis and pure tone audiometry in frequencies of 250, 500, 1000, 2000, 3000, 4000 and 6000 Hz. Blood samples were collected from each patient for analysis of mutations in nuclear and mitochondrial genes related to non-syndromic sensorineural hearing loss. RESULTS: It was observed a greater tendency to noise exposure and consumption of alcohol in the Case Group. The statistically significant symptoms between the groups were tinnitus and hearing difficulty in several situations as: silent environment, telephone, television, sound location and in church. All the individuals of Case Group presented sensorineural and bilateral hearing loss. The symmetry and progression of the hearing impairment were also statistically significant between the groups. No genetic mutations were identified. CONCLUSION: The most reported symptoms were communication difficulties and tinnitus. The predominant auditory characteristics included sensorineural, bilateral, progressive and symmetrical hearing loss. It was not evidenced a relationship between sensorineural hearing loss in elderly and genes considered responsible for non-syndromic hearing loss as no genetic mutation was found in this study.Sociedade Brasileira de Fonoaudiologia2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822013000300006CoDAS v.25 n.3 2013reponame:CoDASinstname:Sociedade Brasileira de Fonoaudiologia (SBFA)instacron:SBFA10.1590/S2317-17822013000300006info:eu-repo/semantics/openAccessMartins,KellyFontenele,MaríliaCâmara,SilvaSartorato,Edi Lúciaeng2013-07-19T00:00:00Zoai:scielo:S2317-17822013000300006Revistahttps://www.codas.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.phpcodas@editoracubo.com.br||revista@codas.org.br2317-17822317-1782opendoar:2013-07-19T00:00CoDAS - Sociedade Brasileira de Fonoaudiologia (SBFA)false |
dc.title.none.fl_str_mv |
Genetic and audiologic study in elderly with sensorineural hearing loss |
title |
Genetic and audiologic study in elderly with sensorineural hearing loss |
spellingShingle |
Genetic and audiologic study in elderly with sensorineural hearing loss Martins,Kelly Hearing loss Aged Presbycusis Deafness Genetics |
title_short |
Genetic and audiologic study in elderly with sensorineural hearing loss |
title_full |
Genetic and audiologic study in elderly with sensorineural hearing loss |
title_fullStr |
Genetic and audiologic study in elderly with sensorineural hearing loss |
title_full_unstemmed |
Genetic and audiologic study in elderly with sensorineural hearing loss |
title_sort |
Genetic and audiologic study in elderly with sensorineural hearing loss |
author |
Martins,Kelly |
author_facet |
Martins,Kelly Fontenele,Marília Câmara,Silva Sartorato,Edi Lúcia |
author_role |
author |
author2 |
Fontenele,Marília Câmara,Silva Sartorato,Edi Lúcia |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Martins,Kelly Fontenele,Marília Câmara,Silva Sartorato,Edi Lúcia |
dc.subject.por.fl_str_mv |
Hearing loss Aged Presbycusis Deafness Genetics |
topic |
Hearing loss Aged Presbycusis Deafness Genetics |
description |
PURPOSE: This study aimed to correlate probable predisposing factors for sensorineural hearing loss in elderly by investigating the audiologic characteristics and frequency of mutations in genes considered responsible for non-syndromic hearing loss. METHODS: Sixty elderly patients were separated into two groups: the Case Group, composed of 30 individuals, 21 females and nine males, all 60 years old or older and presenting diagnoses of sensorineural hearing loss, and the Control Group, composed of 30 elderly individuals matched to the experimental group by age and gender, presenting normal hearing. The patients underwent anamnesis and pure tone audiometry in frequencies of 250, 500, 1000, 2000, 3000, 4000 and 6000 Hz. Blood samples were collected from each patient for analysis of mutations in nuclear and mitochondrial genes related to non-syndromic sensorineural hearing loss. RESULTS: It was observed a greater tendency to noise exposure and consumption of alcohol in the Case Group. The statistically significant symptoms between the groups were tinnitus and hearing difficulty in several situations as: silent environment, telephone, television, sound location and in church. All the individuals of Case Group presented sensorineural and bilateral hearing loss. The symmetry and progression of the hearing impairment were also statistically significant between the groups. No genetic mutations were identified. CONCLUSION: The most reported symptoms were communication difficulties and tinnitus. The predominant auditory characteristics included sensorineural, bilateral, progressive and symmetrical hearing loss. It was not evidenced a relationship between sensorineural hearing loss in elderly and genes considered responsible for non-syndromic hearing loss as no genetic mutation was found in this study. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822013000300006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822013000300006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S2317-17822013000300006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Fonoaudiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Fonoaudiologia |
dc.source.none.fl_str_mv |
CoDAS v.25 n.3 2013 reponame:CoDAS instname:Sociedade Brasileira de Fonoaudiologia (SBFA) instacron:SBFA |
instname_str |
Sociedade Brasileira de Fonoaudiologia (SBFA) |
instacron_str |
SBFA |
institution |
SBFA |
reponame_str |
CoDAS |
collection |
CoDAS |
repository.name.fl_str_mv |
CoDAS - Sociedade Brasileira de Fonoaudiologia (SBFA) |
repository.mail.fl_str_mv |
codas@editoracubo.com.br||revista@codas.org.br |
_version_ |
1752122439935983616 |