Citral reduces nociceptive and inflammatory response in rodents

Detalhes bibliográficos
Autor(a) principal: Quintans-Júnior,Lucindo J.
Data de Publicação: 2011
Outros Autores: Guimarães,Adriana G., Santana,Marilia T. de, Araújo,Bruno E.S., Moreira,Flávia V., Bonjardim,Leonardo R., Araújo,Adriano A. S., Siqueira,Jullyana S., Antoniolli,Ângelo R., Botelho,Marco A., Almeida,Jackson R. G. S., Santos,Márcio R. V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300023
Resumo: Citral (CIT), which contains the chiral enantiomers, neral (cis) and geranial (trans), is the majority monoterpene from Lippia alba and Cymbopogon citratus. The present study aimed to evaluate CIT for antinociceptive and anti-inflammatory activities in rodents. Antinociceptive and anti-inflammatory effects were studied by measuring nociception through acetic acid and formalin tests, while inflammation was verified by inducing peritonitis and paw edema with carrageenan. All tested doses of CIT had significant protection (p<0.001) against acetic acid (0.8%) induced nociceptive behavior and the effects were also similar to morphine while formalin induced nociception was significantly protected (p<0.05) only at higher dose (200 mg/kg) of CIT in the first phase of the test. CIT significantly reduce (p<0.001) nociceptive behavior emanating from inflammation in second phase at all the doses.The pretreatment with CIT (100 and 200 mg/kg) significantly reduced the paw edema induced by carrageenan. Moreover, systemic treatment with CIT (100 and 200 mg/kg) significantly reduced (p<0.001) the leukocyte migration in the carrageenan-induced migration to the peritoneal cavity. Our investigation shows that CIT possess significant central and peripheral antinociceptive effects. It was also verified an anti-inflammatory activity. All together these results suggest that CIT might represent important tool for treatment of painful conditions.
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spelling Citral reduces nociceptive and inflammatory response in rodentsmonoterpenecitralantinociceptiveanti-inflammatoryCitral (CIT), which contains the chiral enantiomers, neral (cis) and geranial (trans), is the majority monoterpene from Lippia alba and Cymbopogon citratus. The present study aimed to evaluate CIT for antinociceptive and anti-inflammatory activities in rodents. Antinociceptive and anti-inflammatory effects were studied by measuring nociception through acetic acid and formalin tests, while inflammation was verified by inducing peritonitis and paw edema with carrageenan. All tested doses of CIT had significant protection (p<0.001) against acetic acid (0.8%) induced nociceptive behavior and the effects were also similar to morphine while formalin induced nociception was significantly protected (p<0.05) only at higher dose (200 mg/kg) of CIT in the first phase of the test. CIT significantly reduce (p<0.001) nociceptive behavior emanating from inflammation in second phase at all the doses.The pretreatment with CIT (100 and 200 mg/kg) significantly reduced the paw edema induced by carrageenan. Moreover, systemic treatment with CIT (100 and 200 mg/kg) significantly reduced (p<0.001) the leukocyte migration in the carrageenan-induced migration to the peritoneal cavity. Our investigation shows that CIT possess significant central and peripheral antinociceptive effects. It was also verified an anti-inflammatory activity. All together these results suggest that CIT might represent important tool for treatment of painful conditions.Sociedade Brasileira de Farmacognosia2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300023Revista Brasileira de Farmacognosia v.21 n.3 2011reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000065info:eu-repo/semantics/openAccessQuintans-Júnior,Lucindo J.Guimarães,Adriana G.Santana,Marilia T. deAraújo,Bruno E.S.Moreira,Flávia V.Bonjardim,Leonardo R.Araújo,Adriano A. S.Siqueira,Jullyana S.Antoniolli,Ângelo R.Botelho,Marco A.Almeida,Jackson R. G. S.Santos,Márcio R. V.eng2011-07-08T00:00:00Zoai:scielo:S0102-695X2011000300023Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-07-08T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Citral reduces nociceptive and inflammatory response in rodents
title Citral reduces nociceptive and inflammatory response in rodents
spellingShingle Citral reduces nociceptive and inflammatory response in rodents
Quintans-Júnior,Lucindo J.
monoterpene
citral
antinociceptive
anti-inflammatory
title_short Citral reduces nociceptive and inflammatory response in rodents
title_full Citral reduces nociceptive and inflammatory response in rodents
title_fullStr Citral reduces nociceptive and inflammatory response in rodents
title_full_unstemmed Citral reduces nociceptive and inflammatory response in rodents
title_sort Citral reduces nociceptive and inflammatory response in rodents
author Quintans-Júnior,Lucindo J.
author_facet Quintans-Júnior,Lucindo J.
Guimarães,Adriana G.
Santana,Marilia T. de
Araújo,Bruno E.S.
Moreira,Flávia V.
Bonjardim,Leonardo R.
Araújo,Adriano A. S.
Siqueira,Jullyana S.
Antoniolli,Ângelo R.
Botelho,Marco A.
Almeida,Jackson R. G. S.
Santos,Márcio R. V.
author_role author
author2 Guimarães,Adriana G.
Santana,Marilia T. de
Araújo,Bruno E.S.
Moreira,Flávia V.
Bonjardim,Leonardo R.
Araújo,Adriano A. S.
Siqueira,Jullyana S.
Antoniolli,Ângelo R.
Botelho,Marco A.
Almeida,Jackson R. G. S.
Santos,Márcio R. V.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Quintans-Júnior,Lucindo J.
Guimarães,Adriana G.
Santana,Marilia T. de
Araújo,Bruno E.S.
Moreira,Flávia V.
Bonjardim,Leonardo R.
Araújo,Adriano A. S.
Siqueira,Jullyana S.
Antoniolli,Ângelo R.
Botelho,Marco A.
Almeida,Jackson R. G. S.
Santos,Márcio R. V.
dc.subject.por.fl_str_mv monoterpene
citral
antinociceptive
anti-inflammatory
topic monoterpene
citral
antinociceptive
anti-inflammatory
description Citral (CIT), which contains the chiral enantiomers, neral (cis) and geranial (trans), is the majority monoterpene from Lippia alba and Cymbopogon citratus. The present study aimed to evaluate CIT for antinociceptive and anti-inflammatory activities in rodents. Antinociceptive and anti-inflammatory effects were studied by measuring nociception through acetic acid and formalin tests, while inflammation was verified by inducing peritonitis and paw edema with carrageenan. All tested doses of CIT had significant protection (p<0.001) against acetic acid (0.8%) induced nociceptive behavior and the effects were also similar to morphine while formalin induced nociception was significantly protected (p<0.05) only at higher dose (200 mg/kg) of CIT in the first phase of the test. CIT significantly reduce (p<0.001) nociceptive behavior emanating from inflammation in second phase at all the doses.The pretreatment with CIT (100 and 200 mg/kg) significantly reduced the paw edema induced by carrageenan. Moreover, systemic treatment with CIT (100 and 200 mg/kg) significantly reduced (p<0.001) the leukocyte migration in the carrageenan-induced migration to the peritoneal cavity. Our investigation shows that CIT possess significant central and peripheral antinociceptive effects. It was also verified an anti-inflammatory activity. All together these results suggest that CIT might represent important tool for treatment of painful conditions.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300023
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2011005000065
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.21 n.3 2011
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
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instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
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collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
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