Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.

Detalhes bibliográficos
Autor(a) principal: QUINTANS JÚNIOR, Lucindo José.
Data de Publicação: 2010
Outros Autores: GUIMARÃES, Adriana G., ARAÚJO, Bruno E. S., OLIVEIRA, Geovana F., SANTANA, Marília T., MOREIRA, Flávia Viana., SANTOS, Márcio R. V., CAVALCANTI, Sócrates Cabral de Holanda., LUCCA JÚNIOR, Waldecir de., BOTELHO, Marco A. ., NÓBREGA, Franklin Ferreira de Farias., ALMEIDA, Reinaldo Nobrega de.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFCG
Texto Completo: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240
Resumo: Carvacrol, a monoterpenic phenol present in essential oils of the Labiatae family, has been used through the ages as a source of flavor in food and for medicinal purposes. Borneol is a monoterpene found in several species of Artemisia and Dipterocarpaceae, used for anxiety, pain and anesthesia in traditional Chinese. Citral, a mixture of two geometrical isomers (neral and geranial), is one of the most important compounds in some citrus oils and has central nervous system (CNS) properties. The anticonvulsant effect of carvacrol (CARV), (−)-borneol (BOR) and citral (CIT) was investigated in two animal models of epilepsy. Mice were pretreated with CARV, BOR or CIT (50, 100, and 200 mg/kg, i.p.) 30 min before pentylenetetrazole (PTZ) or maximal electroshock (MES) tests, the two most important animal epilepsy tests. The latency for development of convulsions and protection percentage was recorded. In order to investigate the involvement of GABAergic system, flumazenil was utilized. These monoterpenes, CARV in a higher, but not in a lower dose (p < 0.001), BOR and CIT in all doses (p < 0.05 or p < 0.001), were capable of promoting an increase of latency for the development of convulsions induced by PTZ. Additionally, these compounds were efficient in preventing the tonic convulsions (p <0.05) induced by MES. However, the GABAergic neurotransmitter system might be involved, at least inBOR effects. Henceforth, our results suggest that CARV, BOR and CIT possess anticonvulsant activity effect against PTZ-induced convulsions and MES.
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spelling Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.Carvacrol, (-)-borneol e citral reduzem a atividade convulsiva em roedores.Carvacrol(−)-borneolCitralAnticonvulsant activityAtividade anticonvulsivanteFarmácia.Química.Carvacrol, a monoterpenic phenol present in essential oils of the Labiatae family, has been used through the ages as a source of flavor in food and for medicinal purposes. Borneol is a monoterpene found in several species of Artemisia and Dipterocarpaceae, used for anxiety, pain and anesthesia in traditional Chinese. Citral, a mixture of two geometrical isomers (neral and geranial), is one of the most important compounds in some citrus oils and has central nervous system (CNS) properties. The anticonvulsant effect of carvacrol (CARV), (−)-borneol (BOR) and citral (CIT) was investigated in two animal models of epilepsy. Mice were pretreated with CARV, BOR or CIT (50, 100, and 200 mg/kg, i.p.) 30 min before pentylenetetrazole (PTZ) or maximal electroshock (MES) tests, the two most important animal epilepsy tests. The latency for development of convulsions and protection percentage was recorded. In order to investigate the involvement of GABAergic system, flumazenil was utilized. These monoterpenes, CARV in a higher, but not in a lower dose (p < 0.001), BOR and CIT in all doses (p < 0.05 or p < 0.001), were capable of promoting an increase of latency for the development of convulsions induced by PTZ. Additionally, these compounds were efficient in preventing the tonic convulsions (p <0.05) induced by MES. However, the GABAergic neurotransmitter system might be involved, at least inBOR effects. Henceforth, our results suggest that CARV, BOR and CIT possess anticonvulsant activity effect against PTZ-induced convulsions and MES.Universidade Federal de Campina GrandeBrasilUFCG20102024-08-09T17:55:09Z2024-08-092024-08-09T17:55:09Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240QUINTANS JÚNIOR, Lucindo José; GUIMARÃES, Adriana.G; ARAÚJO, Bruno E. S.; OLIVEIRA, Geovana F. ; SANTANA, Marília T. ; MOREIRA, Flávia Viana ; SANTOS, Márcio R. V.; CAVALCANTI, Sócrates Cabral de Holanda; LUCCA JÚNIOR, Waldecir de; BOTELHO, Marco A. ; NÓBREGA, Franklin Ferreira de Farias; ALMEIDA, Reinaldo Nobrega de. Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.. African Journal of Biotechnology , v. 9, p. 21-28, 2010. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240engQUINTANS JÚNIOR, Lucindo José.GUIMARÃES, Adriana G.ARAÚJO, Bruno E. S.OLIVEIRA, Geovana F.SANTANA, Marília T.MOREIRA, Flávia Viana.SANTOS, Márcio R. V.CAVALCANTI, Sócrates Cabral de Holanda.LUCCA JÚNIOR, Waldecir de.BOTELHO, Marco A. .NÓBREGA, Franklin Ferreira de Farias.ALMEIDA, Reinaldo Nobrega de.info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFCGinstname:Universidade Federal de Campina Grande (UFCG)instacron:UFCG2024-08-09T17:55:50Zoai:localhost:riufcg/37240Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.ufcg.edu.br/PUBhttp://dspace.sti.ufcg.edu.br:8080/oai/requestbdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.bropendoar:48512024-08-09T17:55:50Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG)false
dc.title.none.fl_str_mv Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.
Carvacrol, (-)-borneol e citral reduzem a atividade convulsiva em roedores.
title Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.
spellingShingle Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.
QUINTANS JÚNIOR, Lucindo José.
Carvacrol
(−)-borneol
Citral
Anticonvulsant activity
Atividade anticonvulsivante
Farmácia.
Química.
title_short Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.
title_full Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.
title_fullStr Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.
title_full_unstemmed Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.
title_sort Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.
author QUINTANS JÚNIOR, Lucindo José.
author_facet QUINTANS JÚNIOR, Lucindo José.
GUIMARÃES, Adriana G.
ARAÚJO, Bruno E. S.
OLIVEIRA, Geovana F.
SANTANA, Marília T.
MOREIRA, Flávia Viana.
SANTOS, Márcio R. V.
CAVALCANTI, Sócrates Cabral de Holanda.
LUCCA JÚNIOR, Waldecir de.
BOTELHO, Marco A. .
NÓBREGA, Franklin Ferreira de Farias.
ALMEIDA, Reinaldo Nobrega de.
author_role author
author2 GUIMARÃES, Adriana G.
ARAÚJO, Bruno E. S.
OLIVEIRA, Geovana F.
SANTANA, Marília T.
MOREIRA, Flávia Viana.
SANTOS, Márcio R. V.
CAVALCANTI, Sócrates Cabral de Holanda.
LUCCA JÚNIOR, Waldecir de.
BOTELHO, Marco A. .
NÓBREGA, Franklin Ferreira de Farias.
ALMEIDA, Reinaldo Nobrega de.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv QUINTANS JÚNIOR, Lucindo José.
GUIMARÃES, Adriana G.
ARAÚJO, Bruno E. S.
OLIVEIRA, Geovana F.
SANTANA, Marília T.
MOREIRA, Flávia Viana.
SANTOS, Márcio R. V.
CAVALCANTI, Sócrates Cabral de Holanda.
LUCCA JÚNIOR, Waldecir de.
BOTELHO, Marco A. .
NÓBREGA, Franklin Ferreira de Farias.
ALMEIDA, Reinaldo Nobrega de.
dc.subject.por.fl_str_mv Carvacrol
(−)-borneol
Citral
Anticonvulsant activity
Atividade anticonvulsivante
Farmácia.
Química.
topic Carvacrol
(−)-borneol
Citral
Anticonvulsant activity
Atividade anticonvulsivante
Farmácia.
Química.
description Carvacrol, a monoterpenic phenol present in essential oils of the Labiatae family, has been used through the ages as a source of flavor in food and for medicinal purposes. Borneol is a monoterpene found in several species of Artemisia and Dipterocarpaceae, used for anxiety, pain and anesthesia in traditional Chinese. Citral, a mixture of two geometrical isomers (neral and geranial), is one of the most important compounds in some citrus oils and has central nervous system (CNS) properties. The anticonvulsant effect of carvacrol (CARV), (−)-borneol (BOR) and citral (CIT) was investigated in two animal models of epilepsy. Mice were pretreated with CARV, BOR or CIT (50, 100, and 200 mg/kg, i.p.) 30 min before pentylenetetrazole (PTZ) or maximal electroshock (MES) tests, the two most important animal epilepsy tests. The latency for development of convulsions and protection percentage was recorded. In order to investigate the involvement of GABAergic system, flumazenil was utilized. These monoterpenes, CARV in a higher, but not in a lower dose (p < 0.001), BOR and CIT in all doses (p < 0.05 or p < 0.001), were capable of promoting an increase of latency for the development of convulsions induced by PTZ. Additionally, these compounds were efficient in preventing the tonic convulsions (p <0.05) induced by MES. However, the GABAergic neurotransmitter system might be involved, at least inBOR effects. Henceforth, our results suggest that CARV, BOR and CIT possess anticonvulsant activity effect against PTZ-induced convulsions and MES.
publishDate 2010
dc.date.none.fl_str_mv 2010
2024-08-09T17:55:09Z
2024-08-09
2024-08-09T17:55:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240
QUINTANS JÚNIOR, Lucindo José; GUIMARÃES, Adriana.G; ARAÚJO, Bruno E. S.; OLIVEIRA, Geovana F. ; SANTANA, Marília T. ; MOREIRA, Flávia Viana ; SANTOS, Márcio R. V.; CAVALCANTI, Sócrates Cabral de Holanda; LUCCA JÚNIOR, Waldecir de; BOTELHO, Marco A. ; NÓBREGA, Franklin Ferreira de Farias; ALMEIDA, Reinaldo Nobrega de. Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.. African Journal of Biotechnology , v. 9, p. 21-28, 2010. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240
url http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240
identifier_str_mv QUINTANS JÚNIOR, Lucindo José; GUIMARÃES, Adriana.G; ARAÚJO, Bruno E. S.; OLIVEIRA, Geovana F. ; SANTANA, Marília T. ; MOREIRA, Flávia Viana ; SANTOS, Márcio R. V.; CAVALCANTI, Sócrates Cabral de Holanda; LUCCA JÚNIOR, Waldecir de; BOTELHO, Marco A. ; NÓBREGA, Franklin Ferreira de Farias; ALMEIDA, Reinaldo Nobrega de. Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.. African Journal of Biotechnology , v. 9, p. 21-28, 2010. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Campina Grande
Brasil
UFCG
publisher.none.fl_str_mv Universidade Federal de Campina Grande
Brasil
UFCG
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFCG
instname:Universidade Federal de Campina Grande (UFCG)
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instname_str Universidade Federal de Campina Grande (UFCG)
instacron_str UFCG
institution UFCG
reponame_str Biblioteca Digital de Teses e Dissertações da UFCG
collection Biblioteca Digital de Teses e Dissertações da UFCG
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG)
repository.mail.fl_str_mv bdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.br
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