Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFCG |
Texto Completo: | http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240 |
Resumo: | Carvacrol, a monoterpenic phenol present in essential oils of the Labiatae family, has been used through the ages as a source of flavor in food and for medicinal purposes. Borneol is a monoterpene found in several species of Artemisia and Dipterocarpaceae, used for anxiety, pain and anesthesia in traditional Chinese. Citral, a mixture of two geometrical isomers (neral and geranial), is one of the most important compounds in some citrus oils and has central nervous system (CNS) properties. The anticonvulsant effect of carvacrol (CARV), (−)-borneol (BOR) and citral (CIT) was investigated in two animal models of epilepsy. Mice were pretreated with CARV, BOR or CIT (50, 100, and 200 mg/kg, i.p.) 30 min before pentylenetetrazole (PTZ) or maximal electroshock (MES) tests, the two most important animal epilepsy tests. The latency for development of convulsions and protection percentage was recorded. In order to investigate the involvement of GABAergic system, flumazenil was utilized. These monoterpenes, CARV in a higher, but not in a lower dose (p < 0.001), BOR and CIT in all doses (p < 0.05 or p < 0.001), were capable of promoting an increase of latency for the development of convulsions induced by PTZ. Additionally, these compounds were efficient in preventing the tonic convulsions (p <0.05) induced by MES. However, the GABAergic neurotransmitter system might be involved, at least inBOR effects. Henceforth, our results suggest that CARV, BOR and CIT possess anticonvulsant activity effect against PTZ-induced convulsions and MES. |
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Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.Carvacrol, (-)-borneol e citral reduzem a atividade convulsiva em roedores.Carvacrol(−)-borneolCitralAnticonvulsant activityAtividade anticonvulsivanteFarmácia.Química.Carvacrol, a monoterpenic phenol present in essential oils of the Labiatae family, has been used through the ages as a source of flavor in food and for medicinal purposes. Borneol is a monoterpene found in several species of Artemisia and Dipterocarpaceae, used for anxiety, pain and anesthesia in traditional Chinese. Citral, a mixture of two geometrical isomers (neral and geranial), is one of the most important compounds in some citrus oils and has central nervous system (CNS) properties. The anticonvulsant effect of carvacrol (CARV), (−)-borneol (BOR) and citral (CIT) was investigated in two animal models of epilepsy. Mice were pretreated with CARV, BOR or CIT (50, 100, and 200 mg/kg, i.p.) 30 min before pentylenetetrazole (PTZ) or maximal electroshock (MES) tests, the two most important animal epilepsy tests. The latency for development of convulsions and protection percentage was recorded. In order to investigate the involvement of GABAergic system, flumazenil was utilized. These monoterpenes, CARV in a higher, but not in a lower dose (p < 0.001), BOR and CIT in all doses (p < 0.05 or p < 0.001), were capable of promoting an increase of latency for the development of convulsions induced by PTZ. Additionally, these compounds were efficient in preventing the tonic convulsions (p <0.05) induced by MES. However, the GABAergic neurotransmitter system might be involved, at least inBOR effects. Henceforth, our results suggest that CARV, BOR and CIT possess anticonvulsant activity effect against PTZ-induced convulsions and MES.Universidade Federal de Campina GrandeBrasilUFCG20102024-08-09T17:55:09Z2024-08-092024-08-09T17:55:09Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240QUINTANS JÚNIOR, Lucindo José; GUIMARÃES, Adriana.G; ARAÚJO, Bruno E. S.; OLIVEIRA, Geovana F. ; SANTANA, Marília T. ; MOREIRA, Flávia Viana ; SANTOS, Márcio R. V.; CAVALCANTI, Sócrates Cabral de Holanda; LUCCA JÚNIOR, Waldecir de; BOTELHO, Marco A. ; NÓBREGA, Franklin Ferreira de Farias; ALMEIDA, Reinaldo Nobrega de. Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.. African Journal of Biotechnology , v. 9, p. 21-28, 2010. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240engQUINTANS JÚNIOR, Lucindo José.GUIMARÃES, Adriana G.ARAÚJO, Bruno E. S.OLIVEIRA, Geovana F.SANTANA, Marília T.MOREIRA, Flávia Viana.SANTOS, Márcio R. V.CAVALCANTI, Sócrates Cabral de Holanda.LUCCA JÚNIOR, Waldecir de.BOTELHO, Marco A. .NÓBREGA, Franklin Ferreira de Farias.ALMEIDA, Reinaldo Nobrega de.info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFCGinstname:Universidade Federal de Campina Grande (UFCG)instacron:UFCG2024-08-09T17:55:50Zoai:localhost:riufcg/37240Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.ufcg.edu.br/PUBhttp://dspace.sti.ufcg.edu.br:8080/oai/requestbdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.bropendoar:48512024-08-09T17:55:50Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG)false |
dc.title.none.fl_str_mv |
Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents. Carvacrol, (-)-borneol e citral reduzem a atividade convulsiva em roedores. |
title |
Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents. |
spellingShingle |
Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents. QUINTANS JÚNIOR, Lucindo José. Carvacrol (−)-borneol Citral Anticonvulsant activity Atividade anticonvulsivante Farmácia. Química. |
title_short |
Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents. |
title_full |
Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents. |
title_fullStr |
Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents. |
title_full_unstemmed |
Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents. |
title_sort |
Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents. |
author |
QUINTANS JÚNIOR, Lucindo José. |
author_facet |
QUINTANS JÚNIOR, Lucindo José. GUIMARÃES, Adriana G. ARAÚJO, Bruno E. S. OLIVEIRA, Geovana F. SANTANA, Marília T. MOREIRA, Flávia Viana. SANTOS, Márcio R. V. CAVALCANTI, Sócrates Cabral de Holanda. LUCCA JÚNIOR, Waldecir de. BOTELHO, Marco A. . NÓBREGA, Franklin Ferreira de Farias. ALMEIDA, Reinaldo Nobrega de. |
author_role |
author |
author2 |
GUIMARÃES, Adriana G. ARAÚJO, Bruno E. S. OLIVEIRA, Geovana F. SANTANA, Marília T. MOREIRA, Flávia Viana. SANTOS, Márcio R. V. CAVALCANTI, Sócrates Cabral de Holanda. LUCCA JÚNIOR, Waldecir de. BOTELHO, Marco A. . NÓBREGA, Franklin Ferreira de Farias. ALMEIDA, Reinaldo Nobrega de. |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
QUINTANS JÚNIOR, Lucindo José. GUIMARÃES, Adriana G. ARAÚJO, Bruno E. S. OLIVEIRA, Geovana F. SANTANA, Marília T. MOREIRA, Flávia Viana. SANTOS, Márcio R. V. CAVALCANTI, Sócrates Cabral de Holanda. LUCCA JÚNIOR, Waldecir de. BOTELHO, Marco A. . NÓBREGA, Franklin Ferreira de Farias. ALMEIDA, Reinaldo Nobrega de. |
dc.subject.por.fl_str_mv |
Carvacrol (−)-borneol Citral Anticonvulsant activity Atividade anticonvulsivante Farmácia. Química. |
topic |
Carvacrol (−)-borneol Citral Anticonvulsant activity Atividade anticonvulsivante Farmácia. Química. |
description |
Carvacrol, a monoterpenic phenol present in essential oils of the Labiatae family, has been used through the ages as a source of flavor in food and for medicinal purposes. Borneol is a monoterpene found in several species of Artemisia and Dipterocarpaceae, used for anxiety, pain and anesthesia in traditional Chinese. Citral, a mixture of two geometrical isomers (neral and geranial), is one of the most important compounds in some citrus oils and has central nervous system (CNS) properties. The anticonvulsant effect of carvacrol (CARV), (−)-borneol (BOR) and citral (CIT) was investigated in two animal models of epilepsy. Mice were pretreated with CARV, BOR or CIT (50, 100, and 200 mg/kg, i.p.) 30 min before pentylenetetrazole (PTZ) or maximal electroshock (MES) tests, the two most important animal epilepsy tests. The latency for development of convulsions and protection percentage was recorded. In order to investigate the involvement of GABAergic system, flumazenil was utilized. These monoterpenes, CARV in a higher, but not in a lower dose (p < 0.001), BOR and CIT in all doses (p < 0.05 or p < 0.001), were capable of promoting an increase of latency for the development of convulsions induced by PTZ. Additionally, these compounds were efficient in preventing the tonic convulsions (p <0.05) induced by MES. However, the GABAergic neurotransmitter system might be involved, at least inBOR effects. Henceforth, our results suggest that CARV, BOR and CIT possess anticonvulsant activity effect against PTZ-induced convulsions and MES. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2024-08-09T17:55:09Z 2024-08-09 2024-08-09T17:55:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240 QUINTANS JÚNIOR, Lucindo José; GUIMARÃES, Adriana.G; ARAÚJO, Bruno E. S.; OLIVEIRA, Geovana F. ; SANTANA, Marília T. ; MOREIRA, Flávia Viana ; SANTOS, Márcio R. V.; CAVALCANTI, Sócrates Cabral de Holanda; LUCCA JÚNIOR, Waldecir de; BOTELHO, Marco A. ; NÓBREGA, Franklin Ferreira de Farias; ALMEIDA, Reinaldo Nobrega de. Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.. African Journal of Biotechnology , v. 9, p. 21-28, 2010. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240 |
url |
http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240 |
identifier_str_mv |
QUINTANS JÚNIOR, Lucindo José; GUIMARÃES, Adriana.G; ARAÚJO, Bruno E. S.; OLIVEIRA, Geovana F. ; SANTANA, Marília T. ; MOREIRA, Flávia Viana ; SANTOS, Márcio R. V.; CAVALCANTI, Sócrates Cabral de Holanda; LUCCA JÚNIOR, Waldecir de; BOTELHO, Marco A. ; NÓBREGA, Franklin Ferreira de Farias; ALMEIDA, Reinaldo Nobrega de. Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents.. African Journal of Biotechnology , v. 9, p. 21-28, 2010. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37240 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Campina Grande Brasil UFCG |
publisher.none.fl_str_mv |
Universidade Federal de Campina Grande Brasil UFCG |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFCG instname:Universidade Federal de Campina Grande (UFCG) instacron:UFCG |
instname_str |
Universidade Federal de Campina Grande (UFCG) |
instacron_str |
UFCG |
institution |
UFCG |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UFCG |
collection |
Biblioteca Digital de Teses e Dissertações da UFCG |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG) |
repository.mail.fl_str_mv |
bdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.br |
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1809744632835211264 |