Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes

Detalhes bibliográficos
Autor(a) principal: Ibrahim,Sabrin
Data de Publicação: 2017
Outros Autores: Al-Ahdal,Abdulrahman, Khedr,Amgad, Mohamed,Gamal
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000200170
Resumo: ABSTRACT A new isoflavonoid glycoside, iridin A (9), along with eight known isoflavonoids: irilone 4'-methyl ether (1), irilone (2), irisolidone (3), irigenin S (4), irigenin (5), irilone 4'-O-β-D-glucopyranoside (6), iridin S (7), and iridin (8) were separated from Iris × germanica L., Iridaceae, rhizomes. The structural elucidation of these flavonoids was achieved with the aid of extensive spectroscopic techniques and comparing with the published data. They were estimated for their α-amylase and 1,1-diphenyl-2-picrylhydrazyl inhibitory capacities. Compounds 3, 5, and 9 showed α-amylase inhibitory activities with % inhibition 70.8, 67.5, and 70.5, respectively compared to acarbose (a reference α-amylase inhibitor). Moreover, 9 exhibited moderate antioxidant activity with IC50 8.91 µM.
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spelling Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomesIridin AIris germanicaIsoflavonoidIridaceaeα-Amylase inhibitorsAntioxidantABSTRACT A new isoflavonoid glycoside, iridin A (9), along with eight known isoflavonoids: irilone 4'-methyl ether (1), irilone (2), irisolidone (3), irigenin S (4), irigenin (5), irilone 4'-O-β-D-glucopyranoside (6), iridin S (7), and iridin (8) were separated from Iris × germanica L., Iridaceae, rhizomes. The structural elucidation of these flavonoids was achieved with the aid of extensive spectroscopic techniques and comparing with the published data. They were estimated for their α-amylase and 1,1-diphenyl-2-picrylhydrazyl inhibitory capacities. Compounds 3, 5, and 9 showed α-amylase inhibitory activities with % inhibition 70.8, 67.5, and 70.5, respectively compared to acarbose (a reference α-amylase inhibitor). Moreover, 9 exhibited moderate antioxidant activity with IC50 8.91 µM.Sociedade Brasileira de Farmacognosia2017-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000200170Revista Brasileira de Farmacognosia v.27 n.2 2017reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2016.10.001info:eu-repo/semantics/openAccessIbrahim,SabrinAl-Ahdal,AbdulrahmanKhedr,AmgadMohamed,Gamaleng2017-04-20T00:00:00Zoai:scielo:S0102-695X2017000200170Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2017-04-20T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
title Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
spellingShingle Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
Ibrahim,Sabrin
Iridin A
Iris germanica
Isoflavonoid
Iridaceae
α-Amylase inhibitors
Antioxidant
title_short Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
title_full Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
title_fullStr Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
title_full_unstemmed Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
title_sort Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
author Ibrahim,Sabrin
author_facet Ibrahim,Sabrin
Al-Ahdal,Abdulrahman
Khedr,Amgad
Mohamed,Gamal
author_role author
author2 Al-Ahdal,Abdulrahman
Khedr,Amgad
Mohamed,Gamal
author2_role author
author
author
dc.contributor.author.fl_str_mv Ibrahim,Sabrin
Al-Ahdal,Abdulrahman
Khedr,Amgad
Mohamed,Gamal
dc.subject.por.fl_str_mv Iridin A
Iris germanica
Isoflavonoid
Iridaceae
α-Amylase inhibitors
Antioxidant
topic Iridin A
Iris germanica
Isoflavonoid
Iridaceae
α-Amylase inhibitors
Antioxidant
description ABSTRACT A new isoflavonoid glycoside, iridin A (9), along with eight known isoflavonoids: irilone 4'-methyl ether (1), irilone (2), irisolidone (3), irigenin S (4), irigenin (5), irilone 4'-O-β-D-glucopyranoside (6), iridin S (7), and iridin (8) were separated from Iris × germanica L., Iridaceae, rhizomes. The structural elucidation of these flavonoids was achieved with the aid of extensive spectroscopic techniques and comparing with the published data. They were estimated for their α-amylase and 1,1-diphenyl-2-picrylhydrazyl inhibitory capacities. Compounds 3, 5, and 9 showed α-amylase inhibitory activities with % inhibition 70.8, 67.5, and 70.5, respectively compared to acarbose (a reference α-amylase inhibitor). Moreover, 9 exhibited moderate antioxidant activity with IC50 8.91 µM.
publishDate 2017
dc.date.none.fl_str_mv 2017-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000200170
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000200170
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2016.10.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.27 n.2 2017
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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