The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300369 |
Resumo: | Abstract To study the hepatoprotective effect of the essential oil of Artemisia capillaris Thunb., Asteraceae, on CCl4-induced liver injury in mice, the levels of serum aspartate aminotransferase and alanine aminotransferase, hepatic levels of reduced glutathione, activity of glutathione peroxidase, and the activities of superoxide dismutase and malondialdehyde were assayed. Administration of the essential oil of A. capillaris at 100 and 50 mg/kg to mice prior to CCl4 injection was shown to confer stronger in vivo protective effects and could observably antagonize the CCl4-induced increase in the serum alanine aminotransferase and aspartate aminotransferase activities and malondialdehyde levels as well as prevent CCl4-induced decrease in the antioxidant superoxide dismutase activity, glutathione level and glutathione peroxidase activity (p < 0.01). The oil mainly contained β-citronellol, 1,8-cineole, camphor, linalool, α-pinene, β-pinene, thymol and myrcene. This finding demonstrates that the essential oil of A. capillaris can protect hepatic function against CCl4-induced liver injury in mice. |
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The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivoEssential oilCarbon tetrachlorideHepatoprotective effectsIn vivoH&EGC–MSAbstract To study the hepatoprotective effect of the essential oil of Artemisia capillaris Thunb., Asteraceae, on CCl4-induced liver injury in mice, the levels of serum aspartate aminotransferase and alanine aminotransferase, hepatic levels of reduced glutathione, activity of glutathione peroxidase, and the activities of superoxide dismutase and malondialdehyde were assayed. Administration of the essential oil of A. capillaris at 100 and 50 mg/kg to mice prior to CCl4 injection was shown to confer stronger in vivo protective effects and could observably antagonize the CCl4-induced increase in the serum alanine aminotransferase and aspartate aminotransferase activities and malondialdehyde levels as well as prevent CCl4-induced decrease in the antioxidant superoxide dismutase activity, glutathione level and glutathione peroxidase activity (p < 0.01). The oil mainly contained β-citronellol, 1,8-cineole, camphor, linalool, α-pinene, β-pinene, thymol and myrcene. This finding demonstrates that the essential oil of A. capillaris can protect hepatic function against CCl4-induced liver injury in mice.Sociedade Brasileira de Farmacognosia2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300369Revista Brasileira de Farmacognosia v.26 n.3 2016reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2016.01.001info:eu-repo/semantics/openAccessGao,QinghanZhao,XinYin,LeiZhang,YuanbinWang,BingWu,XiuliZhang,XinhuiFu,XueyanSun,Weihongeng2016-06-14T00:00:00Zoai:scielo:S0102-695X2016000300369Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2016-06-14T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo |
title |
The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo |
spellingShingle |
The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo Gao,Qinghan Essential oil Carbon tetrachloride Hepatoprotective effects In vivo H&E GC–MS |
title_short |
The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo |
title_full |
The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo |
title_fullStr |
The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo |
title_full_unstemmed |
The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo |
title_sort |
The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo |
author |
Gao,Qinghan |
author_facet |
Gao,Qinghan Zhao,Xin Yin,Lei Zhang,Yuanbin Wang,Bing Wu,Xiuli Zhang,Xinhui Fu,Xueyan Sun,Weihong |
author_role |
author |
author2 |
Zhao,Xin Yin,Lei Zhang,Yuanbin Wang,Bing Wu,Xiuli Zhang,Xinhui Fu,Xueyan Sun,Weihong |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gao,Qinghan Zhao,Xin Yin,Lei Zhang,Yuanbin Wang,Bing Wu,Xiuli Zhang,Xinhui Fu,Xueyan Sun,Weihong |
dc.subject.por.fl_str_mv |
Essential oil Carbon tetrachloride Hepatoprotective effects In vivo H&E GC–MS |
topic |
Essential oil Carbon tetrachloride Hepatoprotective effects In vivo H&E GC–MS |
description |
Abstract To study the hepatoprotective effect of the essential oil of Artemisia capillaris Thunb., Asteraceae, on CCl4-induced liver injury in mice, the levels of serum aspartate aminotransferase and alanine aminotransferase, hepatic levels of reduced glutathione, activity of glutathione peroxidase, and the activities of superoxide dismutase and malondialdehyde were assayed. Administration of the essential oil of A. capillaris at 100 and 50 mg/kg to mice prior to CCl4 injection was shown to confer stronger in vivo protective effects and could observably antagonize the CCl4-induced increase in the serum alanine aminotransferase and aspartate aminotransferase activities and malondialdehyde levels as well as prevent CCl4-induced decrease in the antioxidant superoxide dismutase activity, glutathione level and glutathione peroxidase activity (p < 0.01). The oil mainly contained β-citronellol, 1,8-cineole, camphor, linalool, α-pinene, β-pinene, thymol and myrcene. This finding demonstrates that the essential oil of A. capillaris can protect hepatic function against CCl4-induced liver injury in mice. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300369 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300369 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2016.01.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.26 n.3 2016 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122469765873664 |