Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test

• Autor(a) principal: Leitão,Suzana G.
• Data de Publicação: 2006
• Outros Autores: Castro,Oscar, Fonseca,Eduardo N., Julião,Lisieux S., Tavares,Eliana S., Leo,Rodrigo R.T., Vieira,Ricardo C., Oliveira,Danilo R., Leitão,Gilda G., Martino,Virginia, Sulsen,Valeria, Barbosa,Ymira A.G., Pinheiro,Diva P.G., Silva,Pedro E. Almeida da, Teixeira,Dulcineia F., N. Junior,Ivan, Lourenço,Maria Cristina S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2006000100003
• topic: Mycobacterium tuberculosis; Lantana trifolia; Vitex cooperi; Lippia lacunosa; Lippia rotundifolia; antimycobacterial activity; 20-hydroxyecdysone

Forty eight ethanolic crude extracts and fractions (hexane, dichloromethane, ethyl acetate and n-butanol) from ten Brazilian plants (Leguminosae, Monimiaceae and Verbenaceae), 1 from Costa Rica (Verbenaceae) and 1 from Argentina (Verbenaceae) were screened for anti-mycobacterium activity against Mycobacterium tuberculosis (ATCC-27294H37Rv), by the Alamar Blue test, at a fixed concentration of 100 µg/mL. Out of the forty eight, seven were active at this concentration, corresponding to Lantana trifolia (hexane and dichloromethane extracts from leaves), Vitex cooperi (methanol:water, 1:1 extract from barks), Lippia lacunosa (hexane and dichloromethane extracts from leaves) and Lippia rotundifolia (hexane and dichloromethane extracts from leaves), all from the Verbenaceae family.