Macrophage activation by Paepalanthus spp. extracts

• Autor(a) principal: Moreira,R.R.D.
• Data de Publicação: 2000
• Outros Autores: Carlos,I.Z., Vilegas,W.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2000000100004
• topic: Eriocaulaceae; Paepalanthus; macrophages; hydrogen peroxide

Macrophages are known to play an important role in host defense mechanisms when these cells are stimulated with natural and bacterial products (and others). A variety of cytokines and chemicals compounds are released to induce fundamental defense system. Among them hydrogen peroxide (H2O2) has been identified as molecules having multi-functions. Moreover it has been established that H2O2 is involved is a number physiological processes, e.g., neurotransmission, smooth muscle relaxation or immune regulation. By the determination of hydrogen peroxide (H2O2) in peritoneal macrophage cultures of mice, we determined the immunomodulatory action of two extracts (ethanolic and 70% ethanolic) obtained of the four species to the Paepalanthus genus (Eriocaulaceae) in the concentration of 10 mg/mL. The 70% ethanolic extracts from capitula of P. hilairei, P. robustus, P. vellozioides . and P. speciosus presented higher liberation of H2O2 than the ethanolic extracts.