Chemical constituents of the volatile oil from leaves of Annona coriacea and in vitro antiprotozoal activity

• Autor(a) principal: Siqueira,Carlos A. T.
• Data de Publicação: 2011
• Outros Autores: Oliani,Jocimar, Sartoratto,Adilson, Queiroga,Carmen L., Moreno,Paulo R. H., Reimão,Juliana Q., Tempone,André G., Fischer,Dominique C. H.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000100007
• topic: Annona coriacea Mart.; Annonaceae; volatile oil; GC/MS-GC/FID analysis; in vitro antiprotozoal activity

The essential oil of the leaves from Annona coriacea Mart., Annonaceae, was extracted by hydrodistillation in a Clevenger apparatus and analyzed by GC/MS and GC/FID. The oil yield was 0.05% m/m. Sixty compounds were identified, in a complex mixture of sesquiterpenes (76.7%), monoterpenes (20.0%) and other constituents (3.3%). Bicyclogermacrene was its major compound (39.8%) followed by other sesquiterpenes. Most of the monoterpenes were in low concentration (<1%). Only β-pinene and pseudolimonene presented the highest level of 1.6%. The volatile oil presented anti-leishmanial and trypanocidal activity against promastigotes of four species of Leishmania and trypomastigotes of Trypanosoma cruzi, showing to be more active against Leishmania (L.) chagasi (IC50 39.93 µ g/mL) (95% CI 28.00-56.95 µ g/mL).