Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi

• Autor(a) principal: Regasini,Luis Octávio
• Data de Publicação: 2010
• Outros Autores: Pivatto,Marcos, Scorzoni,Liliana, Benaducci,Tatiane, Fusco-Almeida,Ana Marisa, Giannini,Maria José Soares Mendes, Barreiro,Eliezer Jesus, Siva,Dulce Helena Siqueira, Bolzani,Vanderlan da Silva
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000500009
• topic: Pterogyne nitens; guanidine alkaloids; antifungal; opportunistic fungi; Candida spp.; Cryptococcus neoformans

As part of our ongoing research on antifungal agents from Brazilian flora, eight extracts and twelve fractions from Pterogyne nitens Tul., Fabaceae, were screened for antimicrobial activity against four opportunistic fungi species (Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans) using a broth microdilution method. The present investigation reveals that P. nitens extracts and fractions were more effective against C. krusei and C. parapsilosis than against C. neoformans. The growth of C. albicans was moderately affected by all tested extracts and fractions. The strongest effects were observed for n-butanol fractions from branches (MIC = 15.6 μg/mL) and roots (MIC = 31.2 μg/mL) against C. krusei. Additionally, the chromatographic fractionation of the n-butanol fraction from branches afforded four guanidine alkaloids; N-1,N-2,N-3-triisopentenylguanidine (1), described for the first time in the Fabaceae family, and nitensidines A-C (2-4), which showed moderate activity towards C. krusei (MIC = 62.5 μg/mL) and C. parapsilosis (MIC = 31.2 μg/mL).