Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic

Detalhes bibliográficos
Autor(a) principal: Negri,Giuseppina
Data de Publicação: 2010
Outros Autores: di Santi,Daniel, Tabach,Ricardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000600005
Resumo: Humulus lupulus L., Cannabaceae, is commonly used as light sedative and anxiolytics in folk medicine. HPLC-DAD-ESI-MSn represents a powerful tool for the analysis of natural products, since it can simultaneously provide a UV chromatogram and significant structural information about compounds in complex mixture. The aim of this work was characterize the constituents present in hydroethanolic extract. Compounds 1-9 were tentatively characterized on the basis of UV, MS/MS, after reversed phase separation, retention time and literature data. The main phenolic compounds (based on peak area) were characterized as hulupinic acid (9), cohulupone (8), two oxidized hop alfa-bitter acids (principal constituents), one being a oxidized cohumulinone (5) and the other an oxidized humulinone (7) derivatives, together with a procyanidin dimer B (3), flavonoids rutin (4) and kaempferol-7-O-rutinoside (6). This plant known, due to anxiolytic property and beer flavoring, showed oxidized hop bitter acids, as principal constituents, in its hydroethanolic extract.
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spelling Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolyticHumulus lupulusflavonoid glycosidesoxidized hop bitter acidsHPLC/DAD/MS/MSHumulus lupulus L., Cannabaceae, is commonly used as light sedative and anxiolytics in folk medicine. HPLC-DAD-ESI-MSn represents a powerful tool for the analysis of natural products, since it can simultaneously provide a UV chromatogram and significant structural information about compounds in complex mixture. The aim of this work was characterize the constituents present in hydroethanolic extract. Compounds 1-9 were tentatively characterized on the basis of UV, MS/MS, after reversed phase separation, retention time and literature data. The main phenolic compounds (based on peak area) were characterized as hulupinic acid (9), cohulupone (8), two oxidized hop alfa-bitter acids (principal constituents), one being a oxidized cohumulinone (5) and the other an oxidized humulinone (7) derivatives, together with a procyanidin dimer B (3), flavonoids rutin (4) and kaempferol-7-O-rutinoside (6). This plant known, due to anxiolytic property and beer flavoring, showed oxidized hop bitter acids, as principal constituents, in its hydroethanolic extract.Sociedade Brasileira de Farmacognosia2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000600005Revista Brasileira de Farmacognosia v.20 n.6 2010reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2010005000051info:eu-repo/semantics/openAccessNegri,Giuseppinadi Santi,DanielTabach,Ricardoeng2011-01-17T00:00:00Zoai:scielo:S0102-695X2010000600005Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-01-17T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic
title Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic
spellingShingle Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic
Negri,Giuseppina
Humulus lupulus
flavonoid glycosides
oxidized hop bitter acids
HPLC/DAD/MS/MS
title_short Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic
title_full Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic
title_fullStr Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic
title_full_unstemmed Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic
title_sort Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic
author Negri,Giuseppina
author_facet Negri,Giuseppina
di Santi,Daniel
Tabach,Ricardo
author_role author
author2 di Santi,Daniel
Tabach,Ricardo
author2_role author
author
dc.contributor.author.fl_str_mv Negri,Giuseppina
di Santi,Daniel
Tabach,Ricardo
dc.subject.por.fl_str_mv Humulus lupulus
flavonoid glycosides
oxidized hop bitter acids
HPLC/DAD/MS/MS
topic Humulus lupulus
flavonoid glycosides
oxidized hop bitter acids
HPLC/DAD/MS/MS
description Humulus lupulus L., Cannabaceae, is commonly used as light sedative and anxiolytics in folk medicine. HPLC-DAD-ESI-MSn represents a powerful tool for the analysis of natural products, since it can simultaneously provide a UV chromatogram and significant structural information about compounds in complex mixture. The aim of this work was characterize the constituents present in hydroethanolic extract. Compounds 1-9 were tentatively characterized on the basis of UV, MS/MS, after reversed phase separation, retention time and literature data. The main phenolic compounds (based on peak area) were characterized as hulupinic acid (9), cohulupone (8), two oxidized hop alfa-bitter acids (principal constituents), one being a oxidized cohumulinone (5) and the other an oxidized humulinone (7) derivatives, together with a procyanidin dimer B (3), flavonoids rutin (4) and kaempferol-7-O-rutinoside (6). This plant known, due to anxiolytic property and beer flavoring, showed oxidized hop bitter acids, as principal constituents, in its hydroethanolic extract.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000600005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000600005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2010005000051
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.20 n.6 2010
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
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reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
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