GC-MS analysis and cardiovascular activity of the essential oil of Ocotea duckei

• Autor(a) principal: Barbosa-Filho,José M.
• Data de Publicação: 2008
• Outros Autores: Cunha,Renildo M., Dias,Celidarque S., Athayde-Filho,Petrônio F., Silva,Marcelo S., da-Cunha,Emídio Vasconcelos L., Machado,Maria Iracema L., Craveiro,Afrânio A., Medeiros,Isac A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2008000100009
• topic: Ocotea duckei; Lauraceae; essential oil; GC-MS analysis; cardiovascular activity

The essential oils obtained by steam distillation from the roots, stems, leaves and fruits of Ocotea duckei had their composition analyzed by GC-MS. The pharmacological activity of these oils was also evaluated showing significant cardiovascular effects. Forty-nine substances were identified, consisting of a complex mixture of monoterpenes (45%) and sesquiterpenes (55%). The fruits yielded (1.9%) more essential oil than the stems (1.0%), roots (0.8%) and leaves (0.7%). The main component in the oil of the leaves was trans-caryophyllene (60.54%), in the stem bark beta-eudesmol (27.51%) and in the fruits, dl-limonene (30.12%). The predominant essential oil component in the roots was elemol (24.31%). In non-anaesthetized normotensive rats, the essential oils from different parts of Ocotea duckei (leaves, fruits, stem and roots) induced significant (p < 0.05) hypotension followed by bradycardia.