Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600744 |
Resumo: | ABSTRACT This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism. |
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Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic studyExcretionPlasma concentrationTissue distributionWine-processing technologyABSTRACT This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism.Sociedade Brasileira de Farmacognosia2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600744Revista Brasileira de Farmacognosia v.29 n.6 2019reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2019.08.005info:eu-repo/semantics/openAccessLv,Tong-tongJu,Cheng-guoLiu,Bo-nanRen,Xiao-hangShan,Guo-shunJia,Tian-zhueng2020-01-30T00:00:00Zoai:scielo:S0102-695X2019000600744Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2020-01-30T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study |
title |
Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study |
spellingShingle |
Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study Lv,Tong-tong Excretion Plasma concentration Tissue distribution Wine-processing technology |
title_short |
Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study |
title_full |
Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study |
title_fullStr |
Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study |
title_full_unstemmed |
Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study |
title_sort |
Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study |
author |
Lv,Tong-tong |
author_facet |
Lv,Tong-tong Ju,Cheng-guo Liu,Bo-nan Ren,Xiao-hang Shan,Guo-shun Jia,Tian-zhu |
author_role |
author |
author2 |
Ju,Cheng-guo Liu,Bo-nan Ren,Xiao-hang Shan,Guo-shun Jia,Tian-zhu |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lv,Tong-tong Ju,Cheng-guo Liu,Bo-nan Ren,Xiao-hang Shan,Guo-shun Jia,Tian-zhu |
dc.subject.por.fl_str_mv |
Excretion Plasma concentration Tissue distribution Wine-processing technology |
topic |
Excretion Plasma concentration Tissue distribution Wine-processing technology |
description |
ABSTRACT This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600744 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600744 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2019.08.005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.29 n.6 2019 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122471342931968 |