Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study

Detalhes bibliográficos
Autor(a) principal: Lv,Tong-tong
Data de Publicação: 2019
Outros Autores: Ju,Cheng-guo, Liu,Bo-nan, Ren,Xiao-hang, Shan,Guo-shun, Jia,Tian-zhu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600744
Resumo: ABSTRACT This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism.
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spelling Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic studyExcretionPlasma concentrationTissue distributionWine-processing technologyABSTRACT This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism.Sociedade Brasileira de Farmacognosia2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600744Revista Brasileira de Farmacognosia v.29 n.6 2019reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2019.08.005info:eu-repo/semantics/openAccessLv,Tong-tongJu,Cheng-guoLiu,Bo-nanRen,Xiao-hangShan,Guo-shunJia,Tian-zhueng2020-01-30T00:00:00Zoai:scielo:S0102-695X2019000600744Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2020-01-30T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
title Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
spellingShingle Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
Lv,Tong-tong
Excretion
Plasma concentration
Tissue distribution
Wine-processing technology
title_short Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
title_full Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
title_fullStr Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
title_full_unstemmed Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
title_sort Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
author Lv,Tong-tong
author_facet Lv,Tong-tong
Ju,Cheng-guo
Liu,Bo-nan
Ren,Xiao-hang
Shan,Guo-shun
Jia,Tian-zhu
author_role author
author2 Ju,Cheng-guo
Liu,Bo-nan
Ren,Xiao-hang
Shan,Guo-shun
Jia,Tian-zhu
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lv,Tong-tong
Ju,Cheng-guo
Liu,Bo-nan
Ren,Xiao-hang
Shan,Guo-shun
Jia,Tian-zhu
dc.subject.por.fl_str_mv Excretion
Plasma concentration
Tissue distribution
Wine-processing technology
topic Excretion
Plasma concentration
Tissue distribution
Wine-processing technology
description ABSTRACT This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600744
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600744
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2019.08.005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.29 n.6 2019
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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