HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds

Detalhes bibliográficos
Autor(a) principal: Castañeda-Gómez,Jhon
Data de Publicação: 2017
Outros Autores: Rosas-Ramírez,Daniel, Cruz-Morales,Sara, Fragoso-Serrano,Mabel, Pereda-Miranda,Rogelio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000400434
Resumo: ABSTRACT High performance liquid chromatography profiling with mass spectrometry detection was applicable to identify known and novel multidrug-resistance glycolipid inhibitors from the complex resin glycosides mixture of Ipomoea alba L., Convolvulaceae, seeds. Albinosides X and XI were purified by recycling liquid chromatography and their structural elucidation was accomplished by nuclear magnetic resonance. Albinoside XI exerted a strong potentiation of vinblastine susceptibility in multidrug-resistant human breast carcinoma cells.
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spelling HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seedsHPLC–MS profilingGlycolipidResin glycosideABSTRACT High performance liquid chromatography profiling with mass spectrometry detection was applicable to identify known and novel multidrug-resistance glycolipid inhibitors from the complex resin glycosides mixture of Ipomoea alba L., Convolvulaceae, seeds. Albinosides X and XI were purified by recycling liquid chromatography and their structural elucidation was accomplished by nuclear magnetic resonance. Albinoside XI exerted a strong potentiation of vinblastine susceptibility in multidrug-resistant human breast carcinoma cells.Sociedade Brasileira de Farmacognosia2017-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000400434Revista Brasileira de Farmacognosia v.27 n.4 2017reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2017.05.003info:eu-repo/semantics/openAccessCastañeda-Gómez,JhonRosas-Ramírez,DanielCruz-Morales,SaraFragoso-Serrano,MabelPereda-Miranda,Rogelioeng2017-08-31T00:00:00Zoai:scielo:S0102-695X2017000400434Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2017-08-31T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
title HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
spellingShingle HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
Castañeda-Gómez,Jhon
HPLC–MS profiling
Glycolipid
Resin glycoside
title_short HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
title_full HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
title_fullStr HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
title_full_unstemmed HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
title_sort HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
author Castañeda-Gómez,Jhon
author_facet Castañeda-Gómez,Jhon
Rosas-Ramírez,Daniel
Cruz-Morales,Sara
Fragoso-Serrano,Mabel
Pereda-Miranda,Rogelio
author_role author
author2 Rosas-Ramírez,Daniel
Cruz-Morales,Sara
Fragoso-Serrano,Mabel
Pereda-Miranda,Rogelio
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Castañeda-Gómez,Jhon
Rosas-Ramírez,Daniel
Cruz-Morales,Sara
Fragoso-Serrano,Mabel
Pereda-Miranda,Rogelio
dc.subject.por.fl_str_mv HPLC–MS profiling
Glycolipid
Resin glycoside
topic HPLC–MS profiling
Glycolipid
Resin glycoside
description ABSTRACT High performance liquid chromatography profiling with mass spectrometry detection was applicable to identify known and novel multidrug-resistance glycolipid inhibitors from the complex resin glycosides mixture of Ipomoea alba L., Convolvulaceae, seeds. Albinosides X and XI were purified by recycling liquid chromatography and their structural elucidation was accomplished by nuclear magnetic resonance. Albinoside XI exerted a strong potentiation of vinblastine susceptibility in multidrug-resistant human breast carcinoma cells.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000400434
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000400434
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2017.05.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.27 n.4 2017
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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