Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300304 |
Resumo: | Abstract Spondias mombin L., Anacardiaceae, is a plant native of Brazil, where it is known as "cajá". In order to find a potential application for this native species, the anti-inflammatory and antioxidant effects were investigated. The anti-inflammatory activity was evaluated using the in vivo model carrageenan-induced peritonitis in mice. The in vitro antioxidant potential as well the cytotoxicity against 3T3 fibroblast cells also were evaluated. Through High Performance Liquid Chromatography-diode array detector analysis, an analytic method was developed and validated. It allowed the identification and quantification of ellagic acid and chlorogenic acid in hydroethanolic extract of S. mombin leaves. This extract showed anti-inflammatory effect at 100, 200, 300 and 500 mg/kg, however, the ethyl acetate fraction, at 200 mg/kg, showed the highlighted results. Ellagic acid and chlorogenic acid (2.5, 5 and 10 mg/kg) also inhibited the leukocyte migration to the site of inflammation. The extract, fractions and compounds showed significant antioxidant potential when evaluated in different assays. The results shown in this work suggest the anti-inflammatory potential of the leaf extract of S. mombim on peritonitis model induced by carrageenan, it was also observed antioxidant properties associated with an absence of cytotoxicity in cell culture. Further in vivo studies are required to confirm the anti-inflammatories action of S. mombin and its possible anti-inflammatory mechanisms of action. |
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Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leavesSpondias mombinChemical markerAnti-inflammatory and antioxidantAbstract Spondias mombin L., Anacardiaceae, is a plant native of Brazil, where it is known as "cajá". In order to find a potential application for this native species, the anti-inflammatory and antioxidant effects were investigated. The anti-inflammatory activity was evaluated using the in vivo model carrageenan-induced peritonitis in mice. The in vitro antioxidant potential as well the cytotoxicity against 3T3 fibroblast cells also were evaluated. Through High Performance Liquid Chromatography-diode array detector analysis, an analytic method was developed and validated. It allowed the identification and quantification of ellagic acid and chlorogenic acid in hydroethanolic extract of S. mombin leaves. This extract showed anti-inflammatory effect at 100, 200, 300 and 500 mg/kg, however, the ethyl acetate fraction, at 200 mg/kg, showed the highlighted results. Ellagic acid and chlorogenic acid (2.5, 5 and 10 mg/kg) also inhibited the leukocyte migration to the site of inflammation. The extract, fractions and compounds showed significant antioxidant potential when evaluated in different assays. The results shown in this work suggest the anti-inflammatory potential of the leaf extract of S. mombim on peritonitis model induced by carrageenan, it was also observed antioxidant properties associated with an absence of cytotoxicity in cell culture. Further in vivo studies are required to confirm the anti-inflammatories action of S. mombin and its possible anti-inflammatory mechanisms of action.Sociedade Brasileira de Farmacognosia2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300304Revista Brasileira de Farmacognosia v.26 n.3 2016reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2016.02.002info:eu-repo/semantics/openAccessCabral,BárbaraSiqueira,Emerson M.S.Bitencourt,Mariana A.O.Lima,Maíra C.J.S.Lima,Ana K.Ortmann,Caroline F.Chaves,Vitor C.Fernandes-Pedrosa,Matheus F.Rocha,Hugo A.O.Scortecci,Katia C.Reginatto,Flávio H.Giordani,Raquel B.Zucolotto,Silvana M.eng2016-06-14T00:00:00Zoai:scielo:S0102-695X2016000300304Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2016-06-14T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves |
title |
Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves |
spellingShingle |
Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves Cabral,Bárbara Spondias mombin Chemical marker Anti-inflammatory and antioxidant |
title_short |
Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves |
title_full |
Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves |
title_fullStr |
Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves |
title_full_unstemmed |
Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves |
title_sort |
Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves |
author |
Cabral,Bárbara |
author_facet |
Cabral,Bárbara Siqueira,Emerson M.S. Bitencourt,Mariana A.O. Lima,Maíra C.J.S. Lima,Ana K. Ortmann,Caroline F. Chaves,Vitor C. Fernandes-Pedrosa,Matheus F. Rocha,Hugo A.O. Scortecci,Katia C. Reginatto,Flávio H. Giordani,Raquel B. Zucolotto,Silvana M. |
author_role |
author |
author2 |
Siqueira,Emerson M.S. Bitencourt,Mariana A.O. Lima,Maíra C.J.S. Lima,Ana K. Ortmann,Caroline F. Chaves,Vitor C. Fernandes-Pedrosa,Matheus F. Rocha,Hugo A.O. Scortecci,Katia C. Reginatto,Flávio H. Giordani,Raquel B. Zucolotto,Silvana M. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cabral,Bárbara Siqueira,Emerson M.S. Bitencourt,Mariana A.O. Lima,Maíra C.J.S. Lima,Ana K. Ortmann,Caroline F. Chaves,Vitor C. Fernandes-Pedrosa,Matheus F. Rocha,Hugo A.O. Scortecci,Katia C. Reginatto,Flávio H. Giordani,Raquel B. Zucolotto,Silvana M. |
dc.subject.por.fl_str_mv |
Spondias mombin Chemical marker Anti-inflammatory and antioxidant |
topic |
Spondias mombin Chemical marker Anti-inflammatory and antioxidant |
description |
Abstract Spondias mombin L., Anacardiaceae, is a plant native of Brazil, where it is known as "cajá". In order to find a potential application for this native species, the anti-inflammatory and antioxidant effects were investigated. The anti-inflammatory activity was evaluated using the in vivo model carrageenan-induced peritonitis in mice. The in vitro antioxidant potential as well the cytotoxicity against 3T3 fibroblast cells also were evaluated. Through High Performance Liquid Chromatography-diode array detector analysis, an analytic method was developed and validated. It allowed the identification and quantification of ellagic acid and chlorogenic acid in hydroethanolic extract of S. mombin leaves. This extract showed anti-inflammatory effect at 100, 200, 300 and 500 mg/kg, however, the ethyl acetate fraction, at 200 mg/kg, showed the highlighted results. Ellagic acid and chlorogenic acid (2.5, 5 and 10 mg/kg) also inhibited the leukocyte migration to the site of inflammation. The extract, fractions and compounds showed significant antioxidant potential when evaluated in different assays. The results shown in this work suggest the anti-inflammatory potential of the leaf extract of S. mombim on peritonitis model induced by carrageenan, it was also observed antioxidant properties associated with an absence of cytotoxicity in cell culture. Further in vivo studies are required to confirm the anti-inflammatories action of S. mombin and its possible anti-inflammatory mechanisms of action. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300304 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300304 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2016.02.002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.26 n.3 2016 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122469748047872 |