In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600673 |
Resumo: | ABSTRACT Leishmania infantum is an etiologic agent of visceral leishmaniasis. This disease is a neglected disease that can be fatal if not treated and additionally, the few therapeutic option present several drawbacks, including difficult route of administration and toxicity, which turn the search for new therapeutic alternatives necessary. Herein, we evaluated the leishmanicidal in vitro activity of the solanum extract from Solanum lycocarpum A. St.-Hil., Solanaceae, and the isolated alkaloids solasodine, solamargine and solasonine against promastigotes and intracellular amastigotes of L. infantum. Solasodine (IC50-pro = 4.7 µg/ml; IC50-ama = 10.8 µg/ml) and solamargine (IC50-pro = 8.1 µg/ml; IC50-ama = 3.0 µg/ml) exhibited interesting leishmanicidal ativity. Solasonine was approximately four-times (Selective Index 3.7) more selective to the parasite than to the host cells. This data suggest that solasonine might be considered as a potential drug candidate for leishmaniasis treatment. |
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In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantumNeglected diseaseGlycoalkaloidsVisceral leishmaniasisSolasonineSolamargineSolasodineABSTRACT Leishmania infantum is an etiologic agent of visceral leishmaniasis. This disease is a neglected disease that can be fatal if not treated and additionally, the few therapeutic option present several drawbacks, including difficult route of administration and toxicity, which turn the search for new therapeutic alternatives necessary. Herein, we evaluated the leishmanicidal in vitro activity of the solanum extract from Solanum lycocarpum A. St.-Hil., Solanaceae, and the isolated alkaloids solasodine, solamargine and solasonine against promastigotes and intracellular amastigotes of L. infantum. Solasodine (IC50-pro = 4.7 µg/ml; IC50-ama = 10.8 µg/ml) and solamargine (IC50-pro = 8.1 µg/ml; IC50-ama = 3.0 µg/ml) exhibited interesting leishmanicidal ativity. Solasonine was approximately four-times (Selective Index 3.7) more selective to the parasite than to the host cells. This data suggest that solasonine might be considered as a potential drug candidate for leishmaniasis treatment.Sociedade Brasileira de Farmacognosia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600673Revista Brasileira de Farmacognosia v.28 n.6 2018reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2018.07.008info:eu-repo/semantics/openAccessClementino,Leandro da CostaVelásquez,Angela Maria ArenasPassalacqua,Thais GabanAlmeida,Leticia deGraminha,Marcia A.S.Martins,Gilmarcio Z.Salgueiro,LígiaCavaleiro,CarlosSousa,Maria do CéuMoreira,Raquel R.D.eng2018-11-13T00:00:00Zoai:scielo:S0102-695X2018000600673Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2018-11-13T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
title |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
spellingShingle |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum Clementino,Leandro da Costa Neglected disease Glycoalkaloids Visceral leishmaniasis Solasonine Solamargine Solasodine |
title_short |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
title_full |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
title_fullStr |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
title_full_unstemmed |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
title_sort |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
author |
Clementino,Leandro da Costa |
author_facet |
Clementino,Leandro da Costa Velásquez,Angela Maria Arenas Passalacqua,Thais Gaban Almeida,Leticia de Graminha,Marcia A.S. Martins,Gilmarcio Z. Salgueiro,Lígia Cavaleiro,Carlos Sousa,Maria do Céu Moreira,Raquel R.D. |
author_role |
author |
author2 |
Velásquez,Angela Maria Arenas Passalacqua,Thais Gaban Almeida,Leticia de Graminha,Marcia A.S. Martins,Gilmarcio Z. Salgueiro,Lígia Cavaleiro,Carlos Sousa,Maria do Céu Moreira,Raquel R.D. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Clementino,Leandro da Costa Velásquez,Angela Maria Arenas Passalacqua,Thais Gaban Almeida,Leticia de Graminha,Marcia A.S. Martins,Gilmarcio Z. Salgueiro,Lígia Cavaleiro,Carlos Sousa,Maria do Céu Moreira,Raquel R.D. |
dc.subject.por.fl_str_mv |
Neglected disease Glycoalkaloids Visceral leishmaniasis Solasonine Solamargine Solasodine |
topic |
Neglected disease Glycoalkaloids Visceral leishmaniasis Solasonine Solamargine Solasodine |
description |
ABSTRACT Leishmania infantum is an etiologic agent of visceral leishmaniasis. This disease is a neglected disease that can be fatal if not treated and additionally, the few therapeutic option present several drawbacks, including difficult route of administration and toxicity, which turn the search for new therapeutic alternatives necessary. Herein, we evaluated the leishmanicidal in vitro activity of the solanum extract from Solanum lycocarpum A. St.-Hil., Solanaceae, and the isolated alkaloids solasodine, solamargine and solasonine against promastigotes and intracellular amastigotes of L. infantum. Solasodine (IC50-pro = 4.7 µg/ml; IC50-ama = 10.8 µg/ml) and solamargine (IC50-pro = 8.1 µg/ml; IC50-ama = 3.0 µg/ml) exhibited interesting leishmanicidal ativity. Solasonine was approximately four-times (Selective Index 3.7) more selective to the parasite than to the host cells. This data suggest that solasonine might be considered as a potential drug candidate for leishmaniasis treatment. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600673 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000600673 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2018.07.008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.28 n.6 2018 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122471049330688 |