In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bjp.2018.07.008 http://hdl.handle.net/11449/188123 |
Resumo: | Leishmania infantum is an etiologic agent of visceral leishmaniasis. This disease is a neglected disease that can be fatal if not treated and additionally, the few therapeutic option present several drawbacks, including difficult route of administration and toxicity, which turn the search for new therapeutic alternatives necessary. Herein, we evaluated the leishmanicidal in vitro activity of the solanum extract from Solanum lycocarpum A. St.-Hil., Solanaceae, and the isolated alkaloids solasodine, solamargine and solasonine against promastigotes and intracellular amastigotes of L. infantum. Solasodine (IC50-pro = 4.7 μg/ml; IC50-ama = 10.8 μg/ml) and solamargine (IC50-pro = 8.1 μg/ml; IC50-ama = 3.0 μg/ml) exhibited interesting leishmanicidal ativity. Solasonine was approximately four-times (Selective Index 3.7) more selective to the parasite than to the host cells. This data suggest that solasonine might be considered as a potential drug candidate for leishmaniasis treatment. |
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In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantumGlycoalkaloidsNeglected diseaseSolamargineSolasodineSolasonineVisceral leishmaniasisLeishmania infantum is an etiologic agent of visceral leishmaniasis. This disease is a neglected disease that can be fatal if not treated and additionally, the few therapeutic option present several drawbacks, including difficult route of administration and toxicity, which turn the search for new therapeutic alternatives necessary. Herein, we evaluated the leishmanicidal in vitro activity of the solanum extract from Solanum lycocarpum A. St.-Hil., Solanaceae, and the isolated alkaloids solasodine, solamargine and solasonine against promastigotes and intracellular amastigotes of L. infantum. Solasodine (IC50-pro = 4.7 μg/ml; IC50-ama = 10.8 μg/ml) and solamargine (IC50-pro = 8.1 μg/ml; IC50-ama = 3.0 μg/ml) exhibited interesting leishmanicidal ativity. Solasonine was approximately four-times (Selective Index 3.7) more selective to the parasite than to the host cells. This data suggest that solasonine might be considered as a potential drug candidate for leishmaniasis treatment.Instituto de Química UNESP – Universidade Estadual Paulista Programa de Pós-graduação em BiotecnologiaFaculdade de Ciências Farmacêuticas UNESP – Universidade Estadual Paulista Departamento de Análises ClínicasCentro Universitário da Fundação Educacional de BarretosFaculdade de Farmácia Universidade de CoimbraDepartamento de Princípios Ativos e Naturais Faculdade de Ciências Farmacêuticas UNESP – Universidade Estadual PaulistaInstituto de Química UNESP – Universidade Estadual Paulista Programa de Pós-graduação em BiotecnologiaFaculdade de Ciências Farmacêuticas UNESP – Universidade Estadual Paulista Departamento de Análises ClínicasDepartamento de Princípios Ativos e Naturais Faculdade de Ciências Farmacêuticas UNESP – Universidade Estadual PaulistaUniversidade Estadual Paulista (Unesp)Centro Universitário da Fundação Educacional de BarretosUniversidade de CoimbraClementino, Leandro da Costa [UNESP]Velásquez, Angela Maria Arenas [UNESP]Passalacqua, Thais Gaban [UNESP]de Almeida, Leticia [UNESP]Graminha, Marcia A.S. [UNESP]Martins, Gilmarcio Z.Salgueiro, LígiaCavaleiro, CarlosSousa, Maria do CéuMoreira, Raquel R.D. [UNESP]2019-10-06T15:58:00Z2019-10-06T15:58:00Z2018-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article673-677application/pdfhttp://dx.doi.org/10.1016/j.bjp.2018.07.008Brazilian Journal of Pharmacognosy, v. 28, n. 6, p. 673-677, 2018.0102-695Xhttp://hdl.handle.net/11449/18812310.1016/j.bjp.2018.07.008S0102-695X20180006006732-s2.0-85054080579S0102-695X2018000600673.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Pharmacognosyinfo:eu-repo/semantics/openAccess2023-10-04T06:02:59Zoai:repositorio.unesp.br:11449/188123Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-04T06:02:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
title |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
spellingShingle |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum Clementino, Leandro da Costa [UNESP] Glycoalkaloids Neglected disease Solamargine Solasodine Solasonine Visceral leishmaniasis |
title_short |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
title_full |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
title_fullStr |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
title_full_unstemmed |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
title_sort |
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum |
author |
Clementino, Leandro da Costa [UNESP] |
author_facet |
Clementino, Leandro da Costa [UNESP] Velásquez, Angela Maria Arenas [UNESP] Passalacqua, Thais Gaban [UNESP] de Almeida, Leticia [UNESP] Graminha, Marcia A.S. [UNESP] Martins, Gilmarcio Z. Salgueiro, Lígia Cavaleiro, Carlos Sousa, Maria do Céu Moreira, Raquel R.D. [UNESP] |
author_role |
author |
author2 |
Velásquez, Angela Maria Arenas [UNESP] Passalacqua, Thais Gaban [UNESP] de Almeida, Leticia [UNESP] Graminha, Marcia A.S. [UNESP] Martins, Gilmarcio Z. Salgueiro, Lígia Cavaleiro, Carlos Sousa, Maria do Céu Moreira, Raquel R.D. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Centro Universitário da Fundação Educacional de Barretos Universidade de Coimbra |
dc.contributor.author.fl_str_mv |
Clementino, Leandro da Costa [UNESP] Velásquez, Angela Maria Arenas [UNESP] Passalacqua, Thais Gaban [UNESP] de Almeida, Leticia [UNESP] Graminha, Marcia A.S. [UNESP] Martins, Gilmarcio Z. Salgueiro, Lígia Cavaleiro, Carlos Sousa, Maria do Céu Moreira, Raquel R.D. [UNESP] |
dc.subject.por.fl_str_mv |
Glycoalkaloids Neglected disease Solamargine Solasodine Solasonine Visceral leishmaniasis |
topic |
Glycoalkaloids Neglected disease Solamargine Solasodine Solasonine Visceral leishmaniasis |
description |
Leishmania infantum is an etiologic agent of visceral leishmaniasis. This disease is a neglected disease that can be fatal if not treated and additionally, the few therapeutic option present several drawbacks, including difficult route of administration and toxicity, which turn the search for new therapeutic alternatives necessary. Herein, we evaluated the leishmanicidal in vitro activity of the solanum extract from Solanum lycocarpum A. St.-Hil., Solanaceae, and the isolated alkaloids solasodine, solamargine and solasonine against promastigotes and intracellular amastigotes of L. infantum. Solasodine (IC50-pro = 4.7 μg/ml; IC50-ama = 10.8 μg/ml) and solamargine (IC50-pro = 8.1 μg/ml; IC50-ama = 3.0 μg/ml) exhibited interesting leishmanicidal ativity. Solasonine was approximately four-times (Selective Index 3.7) more selective to the parasite than to the host cells. This data suggest that solasonine might be considered as a potential drug candidate for leishmaniasis treatment. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-01 2019-10-06T15:58:00Z 2019-10-06T15:58:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bjp.2018.07.008 Brazilian Journal of Pharmacognosy, v. 28, n. 6, p. 673-677, 2018. 0102-695X http://hdl.handle.net/11449/188123 10.1016/j.bjp.2018.07.008 S0102-695X2018000600673 2-s2.0-85054080579 S0102-695X2018000600673.pdf |
url |
http://dx.doi.org/10.1016/j.bjp.2018.07.008 http://hdl.handle.net/11449/188123 |
identifier_str_mv |
Brazilian Journal of Pharmacognosy, v. 28, n. 6, p. 673-677, 2018. 0102-695X 10.1016/j.bjp.2018.07.008 S0102-695X2018000600673 2-s2.0-85054080579 S0102-695X2018000600673.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Pharmacognosy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
673-677 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964426596515840 |