Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents

Detalhes bibliográficos
Autor(a) principal: Escobedo-Martínez,Carolina
Data de Publicação: 2017
Outros Autores: Guzmán-Gutiérrez,Silvia Laura, Hernández-Méndez,María de los Milagros, Cassani,Julia, Trujillo-Valdivia,Alfonso, Orozco-Castellanos,Luis Manuel, Enríquez,Raúl G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000200214
Resumo: ABSTRACT This study assesses the anti-arthritic effect of the affinin-enriched (spilanthol, main alkamide) hexane extract from the roots of Heliopsis longipes (A. Gray) S.F. Blake, Asteraceae, on a Freund adjuvant-induced arthritis model in rodents. The extract was orally administered at a dose of 2, 6.6, or 20 mg/kg; a significant edema-inhibitory activity in the acute and chronic phases was observed with a dose of 2 and 20 mg/kg, respectively. The extract showed higher anti-inflammatory and anti-arthritic effects than the reference drug phenylbutazone (80 mg/kg). Moreover, the extract prevented the occurrence of secondary lesions associated to this pharmacological model.
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spelling Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodentsHeliopsis longipesAffininAnti-arthriticComplete Freund adjuvantSpilantholABSTRACT This study assesses the anti-arthritic effect of the affinin-enriched (spilanthol, main alkamide) hexane extract from the roots of Heliopsis longipes (A. Gray) S.F. Blake, Asteraceae, on a Freund adjuvant-induced arthritis model in rodents. The extract was orally administered at a dose of 2, 6.6, or 20 mg/kg; a significant edema-inhibitory activity in the acute and chronic phases was observed with a dose of 2 and 20 mg/kg, respectively. The extract showed higher anti-inflammatory and anti-arthritic effects than the reference drug phenylbutazone (80 mg/kg). Moreover, the extract prevented the occurrence of secondary lesions associated to this pharmacological model.Sociedade Brasileira de Farmacognosia2017-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000200214Revista Brasileira de Farmacognosia v.27 n.2 2017reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2016.09.003info:eu-repo/semantics/openAccessEscobedo-Martínez,CarolinaGuzmán-Gutiérrez,Silvia LauraHernández-Méndez,María de los MilagrosCassani,JuliaTrujillo-Valdivia,AlfonsoOrozco-Castellanos,Luis ManuelEnríquez,Raúl G.eng2017-04-20T00:00:00Zoai:scielo:S0102-695X2017000200214Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2017-04-20T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
title Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
spellingShingle Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
Escobedo-Martínez,Carolina
Heliopsis longipes
Affinin
Anti-arthritic
Complete Freund adjuvant
Spilanthol
title_short Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
title_full Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
title_fullStr Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
title_full_unstemmed Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
title_sort Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
author Escobedo-Martínez,Carolina
author_facet Escobedo-Martínez,Carolina
Guzmán-Gutiérrez,Silvia Laura
Hernández-Méndez,María de los Milagros
Cassani,Julia
Trujillo-Valdivia,Alfonso
Orozco-Castellanos,Luis Manuel
Enríquez,Raúl G.
author_role author
author2 Guzmán-Gutiérrez,Silvia Laura
Hernández-Méndez,María de los Milagros
Cassani,Julia
Trujillo-Valdivia,Alfonso
Orozco-Castellanos,Luis Manuel
Enríquez,Raúl G.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Escobedo-Martínez,Carolina
Guzmán-Gutiérrez,Silvia Laura
Hernández-Méndez,María de los Milagros
Cassani,Julia
Trujillo-Valdivia,Alfonso
Orozco-Castellanos,Luis Manuel
Enríquez,Raúl G.
dc.subject.por.fl_str_mv Heliopsis longipes
Affinin
Anti-arthritic
Complete Freund adjuvant
Spilanthol
topic Heliopsis longipes
Affinin
Anti-arthritic
Complete Freund adjuvant
Spilanthol
description ABSTRACT This study assesses the anti-arthritic effect of the affinin-enriched (spilanthol, main alkamide) hexane extract from the roots of Heliopsis longipes (A. Gray) S.F. Blake, Asteraceae, on a Freund adjuvant-induced arthritis model in rodents. The extract was orally administered at a dose of 2, 6.6, or 20 mg/kg; a significant edema-inhibitory activity in the acute and chronic phases was observed with a dose of 2 and 20 mg/kg, respectively. The extract showed higher anti-inflammatory and anti-arthritic effects than the reference drug phenylbutazone (80 mg/kg). Moreover, the extract prevented the occurrence of secondary lesions associated to this pharmacological model.
publishDate 2017
dc.date.none.fl_str_mv 2017-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000200214
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000200214
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2016.09.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.27 n.2 2017
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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