Fish oil as effective supplement preventing inflammatory and histopathological alterations in adjuvant-induced arthritis in rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/14046 |
Resumo: | In this study was investigated the effect of treatment with a fish oil preparation (FOP) on inflammatory and histopathological parameters in a rat model of adjuvant-induced arthritis (AIA). Paw edema, the severity of secondary lesions, the number of synovial leukocytes, and serum nitric oxide and cytokines concentrations were evaluated. Histological changes in cartilage and bone of the femorotibial articulation in the paws were analyzed by hematoxylin/eosin and sirius red-hematoxylin staining. Oral treatment with the FOP (75, 150, and 300 mg/kg) that was initiated on the day of arthritis induction (day zero) and maintained for 21 days inhibited inflammatory signals and prevented morphological changes in cartilage and bone of the femorotibial articulation of the paws. These effects could be at least partially attributable to inhibitory and modulatory actions of the FOP on the production and release of nitric oxide and cytokines that participate in the pathophysiology of AIA. |
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Fish oil as effective supplement preventing inflammatory and histopathological alterations in adjuvant-induced arthritis in ratsEl aceite de pescado como complement eficaz en la prevención de cambios inflamatorios e histopatológicos en la artritis inducida por adyuvantes en ratasÓleo de Peixe como suplemento eficaz na prevenção de alterações inflamatórias e histopatológicas na artrite induzida por adjuvante em ratos Aceite de pescadoAdyuvante completo de FreundEfecto antiinflamatórioCitocinas.Fish oilFreund’s complete adjuvantAntiinflammatory effectCytokines.Óleo de peixeAdjuvante completo de FreundEfeito anti-inflamatórioCitocinas.In this study was investigated the effect of treatment with a fish oil preparation (FOP) on inflammatory and histopathological parameters in a rat model of adjuvant-induced arthritis (AIA). Paw edema, the severity of secondary lesions, the number of synovial leukocytes, and serum nitric oxide and cytokines concentrations were evaluated. Histological changes in cartilage and bone of the femorotibial articulation in the paws were analyzed by hematoxylin/eosin and sirius red-hematoxylin staining. Oral treatment with the FOP (75, 150, and 300 mg/kg) that was initiated on the day of arthritis induction (day zero) and maintained for 21 days inhibited inflammatory signals and prevented morphological changes in cartilage and bone of the femorotibial articulation of the paws. These effects could be at least partially attributable to inhibitory and modulatory actions of the FOP on the production and release of nitric oxide and cytokines that participate in the pathophysiology of AIA.En este estudio se investigó el efecto del tratamiento con una preparación de aceite de pescado (PAP) sobre los parámetros inflamatorios y histopatológicos en un modelo de artritis inducida por adyuvante en ratas (AIA). Se evaluó el edema de la pata, la gravedad de las lesiones secundarias, el número de leucocitos sinoviales y las concentraciones séricas de óxido nítrico y citocinas. Los cambios histológicos en el cartílago y el hueso de la articulación femorotibial en las patas se analizaron mediante tinción con hematoxilina / eosina y rojo de sirio-hematoxilina. El tratamiento oral con PAP (75, 150 y 300 mg / kg) que se inició el día de la inducción de la artritis (día zero) y se mantuvo durante 21 días inhibió las señales inflamatorios y previno cambios morfológicos en el cartílago y hueso de la articulación femorotibial de las patas. Estos efectos podrían atribuirse, al menos en parte, a las acciones inhibidoras y moduladoras de la PAP sobre la producción y liberación de óxido nítrico y citocinas que participan en la fisiopatología de la AIA.Nesse estudo foi investigado o efeito do tratamento com uma preparação de óleo de peixe (POP) sobre parâmetros inflamatórios e histopatológicos na artrite induzida por adjuvante em ratos (AIA). O edema de pata, a gravidade das lesões secundárias, o número de leucócitos sinoviais e a concentração sérica de óxido nítrico e de citocinas foram avaliados. Alterações histológicas nas cartilagens e nos ossos das articulações fêmoro-tibiais das patas foram analisadas pelas técnicas de coloração hematoxilina/eosina e sirius red-hematoxilina. O tratamento oral com a POP (75, 150, e 300 mg/kg) iniciado no dia da indução da artrite (dia zero) e mantido por 21 dias inibiu os sinais inflamatórios e preveniu as alterações morfológicas na cartilagem e no osso das articulações. Esses efeitos podem ser parcialmente atribuídos à ação modulatória e inibitória da POP sobre a produção/liberação de óxido nítrico e citocinas que participam da fisiopatologia da AIA.Research, Society and Development2021-04-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1404610.33448/rsd-v10i4.14046Research, Society and Development; Vol. 10 No. 4; e22610414046Research, Society and Development; Vol. 10 Núm. 4; e22610414046Research, Society and Development; v. 10 n. 4; e226104140462525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/14046/12615Copyright (c) 2021 Camila Fernanda Estevão-Silva ; Alessandra Mileni Versuti Ritter; Franciele Queiroz Ames; Bruno Ambrósio da Rocha; Jurandir Fernando Comar ; Edirlene Sara Wisniewski-Rebecca; Silvana Martins Caparroz-Assef; Roberto Kenji Nakamura Cuman; Luzmarina Hernandes; Ciomar Aparecida Bersani-Amadohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessEstevão-Silva , Camila Fernanda Ritter, Alessandra Mileni Versuti Ames, Franciele Queiroz Rocha, Bruno Ambrósio da Comar , Jurandir Fernando Wisniewski-Rebecca, Edirlene Sara Caparroz-Assef, Silvana Martins Cuman, Roberto Kenji NakamuraHernandes, Luzmarina Bersani-Amado, Ciomar Aparecida 2021-04-25T11:21:26Zoai:ojs.pkp.sfu.ca:article/14046Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:15.683616Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Fish oil as effective supplement preventing inflammatory and histopathological alterations in adjuvant-induced arthritis in rats El aceite de pescado como complement eficaz en la prevención de cambios inflamatorios e histopatológicos en la artritis inducida por adyuvantes en ratas Óleo de Peixe como suplemento eficaz na prevenção de alterações inflamatórias e histopatológicas na artrite induzida por adjuvante em ratos |
| title |
Fish oil as effective supplement preventing inflammatory and histopathological alterations in adjuvant-induced arthritis in rats |
| spellingShingle |
Fish oil as effective supplement preventing inflammatory and histopathological alterations in adjuvant-induced arthritis in rats Estevão-Silva , Camila Fernanda Aceite de pescado Adyuvante completo de Freund Efecto antiinflamatório Citocinas. Fish oil Freund’s complete adjuvant Antiinflammatory effect Cytokines. Óleo de peixe Adjuvante completo de Freund Efeito anti-inflamatório Citocinas. |
| title_short |
Fish oil as effective supplement preventing inflammatory and histopathological alterations in adjuvant-induced arthritis in rats |
| title_full |
Fish oil as effective supplement preventing inflammatory and histopathological alterations in adjuvant-induced arthritis in rats |
| title_fullStr |
Fish oil as effective supplement preventing inflammatory and histopathological alterations in adjuvant-induced arthritis in rats |
| title_full_unstemmed |
Fish oil as effective supplement preventing inflammatory and histopathological alterations in adjuvant-induced arthritis in rats |
| title_sort |
Fish oil as effective supplement preventing inflammatory and histopathological alterations in adjuvant-induced arthritis in rats |
| author |
Estevão-Silva , Camila Fernanda |
| author_facet |
Estevão-Silva , Camila Fernanda Ritter, Alessandra Mileni Versuti Ames, Franciele Queiroz Rocha, Bruno Ambrósio da Comar , Jurandir Fernando Wisniewski-Rebecca, Edirlene Sara Caparroz-Assef, Silvana Martins Cuman, Roberto Kenji Nakamura Hernandes, Luzmarina Bersani-Amado, Ciomar Aparecida |
| author_role |
author |
| author2 |
Ritter, Alessandra Mileni Versuti Ames, Franciele Queiroz Rocha, Bruno Ambrósio da Comar , Jurandir Fernando Wisniewski-Rebecca, Edirlene Sara Caparroz-Assef, Silvana Martins Cuman, Roberto Kenji Nakamura Hernandes, Luzmarina Bersani-Amado, Ciomar Aparecida |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Estevão-Silva , Camila Fernanda Ritter, Alessandra Mileni Versuti Ames, Franciele Queiroz Rocha, Bruno Ambrósio da Comar , Jurandir Fernando Wisniewski-Rebecca, Edirlene Sara Caparroz-Assef, Silvana Martins Cuman, Roberto Kenji Nakamura Hernandes, Luzmarina Bersani-Amado, Ciomar Aparecida |
| dc.subject.por.fl_str_mv |
Aceite de pescado Adyuvante completo de Freund Efecto antiinflamatório Citocinas. Fish oil Freund’s complete adjuvant Antiinflammatory effect Cytokines. Óleo de peixe Adjuvante completo de Freund Efeito anti-inflamatório Citocinas. |
| topic |
Aceite de pescado Adyuvante completo de Freund Efecto antiinflamatório Citocinas. Fish oil Freund’s complete adjuvant Antiinflammatory effect Cytokines. Óleo de peixe Adjuvante completo de Freund Efeito anti-inflamatório Citocinas. |
| description |
In this study was investigated the effect of treatment with a fish oil preparation (FOP) on inflammatory and histopathological parameters in a rat model of adjuvant-induced arthritis (AIA). Paw edema, the severity of secondary lesions, the number of synovial leukocytes, and serum nitric oxide and cytokines concentrations were evaluated. Histological changes in cartilage and bone of the femorotibial articulation in the paws were analyzed by hematoxylin/eosin and sirius red-hematoxylin staining. Oral treatment with the FOP (75, 150, and 300 mg/kg) that was initiated on the day of arthritis induction (day zero) and maintained for 21 days inhibited inflammatory signals and prevented morphological changes in cartilage and bone of the femorotibial articulation of the paws. These effects could be at least partially attributable to inhibitory and modulatory actions of the FOP on the production and release of nitric oxide and cytokines that participate in the pathophysiology of AIA. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-04-08 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/14046 10.33448/rsd-v10i4.14046 |
| url |
https://rsdjournal.org/index.php/rsd/article/view/14046 |
| identifier_str_mv |
10.33448/rsd-v10i4.14046 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/14046/12615 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Research, Society and Development |
| publisher.none.fl_str_mv |
Research, Society and Development |
| dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 4; e22610414046 Research, Society and Development; Vol. 10 Núm. 4; e22610414046 Research, Society and Development; v. 10 n. 4; e22610414046 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052747693948928 |