Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2005000400003 |
Resumo: | Bursera graveolens (Burseraceae), known in Colombia as "sasafrás", is useful for its medicinal properties and is rich in secondary metabolites. In our research, we carried out antimicrobial tests of several fractions and ethanolic extracts from aerial parts against Bacillus subtilis and Staphylococcus aureus, that showed growth inhibitory activity when applied at 250 mg/mL for extracts and 150 mg/mL for fractions. We carried out an antiinflamatory assay also, that showed 71% of inhibition by extracts (81% of Indomethacin) and 70% of inhibition by fractions (78% of Indomethacin). Phytochemical investigation of the bark of Bursera graveolens (Burseraceae) yielded three tetracyclic triterpene acids that have oxygenation in C-3, carboxylic acid in C-21 and unsaturation in C-24 and have been identified as 3-oxotirucalla-8,24-dien-21-oic acid (b-elemonic acid), 3a-hydroxytirucalla-8,24-dien-21-oic acid (a-elemolic acid) and 3a-hydroxytirucalla-7,24-dien-21-oic acid. The isolated compounds were identified using spectroscopic methods including one and two-dimensional Nuclear Magnetic Resonance (COSY, HMQC, HMBC, NOESY) experiments and comparison with published data. This is the first report of the isolated compounds in Bursera graveolens and they have a very important chemotaxonomic significance within the Burseraceae family and related families from the order Rutales. |
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Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologicaBursera graveolensBurseraceaeantiinflamatoryantimicrobialtriterpenestirucallanesBursera graveolens (Burseraceae), known in Colombia as "sasafrás", is useful for its medicinal properties and is rich in secondary metabolites. In our research, we carried out antimicrobial tests of several fractions and ethanolic extracts from aerial parts against Bacillus subtilis and Staphylococcus aureus, that showed growth inhibitory activity when applied at 250 mg/mL for extracts and 150 mg/mL for fractions. We carried out an antiinflamatory assay also, that showed 71% of inhibition by extracts (81% of Indomethacin) and 70% of inhibition by fractions (78% of Indomethacin). Phytochemical investigation of the bark of Bursera graveolens (Burseraceae) yielded three tetracyclic triterpene acids that have oxygenation in C-3, carboxylic acid in C-21 and unsaturation in C-24 and have been identified as 3-oxotirucalla-8,24-dien-21-oic acid (b-elemonic acid), 3a-hydroxytirucalla-8,24-dien-21-oic acid (a-elemolic acid) and 3a-hydroxytirucalla-7,24-dien-21-oic acid. The isolated compounds were identified using spectroscopic methods including one and two-dimensional Nuclear Magnetic Resonance (COSY, HMQC, HMBC, NOESY) experiments and comparison with published data. This is the first report of the isolated compounds in Bursera graveolens and they have a very important chemotaxonomic significance within the Burseraceae family and related families from the order Rutales.Sociedade Brasileira de Farmacognosia2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2005000400003Revista Brasileira de Farmacognosia v.15 n.4 2005reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2005000400003info:eu-repo/semantics/openAccessRobles,JorgeTorrenegra,RubenGray,Alexander I.Piñeros,CatalinaOrtiz,LibiaSierra,Marthaspa2008-05-05T00:00:00Zoai:scielo:S0102-695X2005000400003Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2008-05-05T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica |
title |
Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica |
spellingShingle |
Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica Robles,Jorge Bursera graveolens Burseraceae antiinflamatory antimicrobial triterpenes tirucallanes |
title_short |
Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica |
title_full |
Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica |
title_fullStr |
Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica |
title_full_unstemmed |
Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica |
title_sort |
Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica |
author |
Robles,Jorge |
author_facet |
Robles,Jorge Torrenegra,Ruben Gray,Alexander I. Piñeros,Catalina Ortiz,Libia Sierra,Martha |
author_role |
author |
author2 |
Torrenegra,Ruben Gray,Alexander I. Piñeros,Catalina Ortiz,Libia Sierra,Martha |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Robles,Jorge Torrenegra,Ruben Gray,Alexander I. Piñeros,Catalina Ortiz,Libia Sierra,Martha |
dc.subject.por.fl_str_mv |
Bursera graveolens Burseraceae antiinflamatory antimicrobial triterpenes tirucallanes |
topic |
Bursera graveolens Burseraceae antiinflamatory antimicrobial triterpenes tirucallanes |
description |
Bursera graveolens (Burseraceae), known in Colombia as "sasafrás", is useful for its medicinal properties and is rich in secondary metabolites. In our research, we carried out antimicrobial tests of several fractions and ethanolic extracts from aerial parts against Bacillus subtilis and Staphylococcus aureus, that showed growth inhibitory activity when applied at 250 mg/mL for extracts and 150 mg/mL for fractions. We carried out an antiinflamatory assay also, that showed 71% of inhibition by extracts (81% of Indomethacin) and 70% of inhibition by fractions (78% of Indomethacin). Phytochemical investigation of the bark of Bursera graveolens (Burseraceae) yielded three tetracyclic triterpene acids that have oxygenation in C-3, carboxylic acid in C-21 and unsaturation in C-24 and have been identified as 3-oxotirucalla-8,24-dien-21-oic acid (b-elemonic acid), 3a-hydroxytirucalla-8,24-dien-21-oic acid (a-elemolic acid) and 3a-hydroxytirucalla-7,24-dien-21-oic acid. The isolated compounds were identified using spectroscopic methods including one and two-dimensional Nuclear Magnetic Resonance (COSY, HMQC, HMBC, NOESY) experiments and comparison with published data. This is the first report of the isolated compounds in Bursera graveolens and they have a very important chemotaxonomic significance within the Burseraceae family and related families from the order Rutales. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2005000400003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2005000400003 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2005000400003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.15 n.4 2005 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122461808230400 |