In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus

Detalhes bibliográficos
Autor(a) principal: Evina,Jean Noel
Data de Publicação: 2017
Outros Autores: Bikobo,Dominique Serge Ngono, Zintchem,Auguste Abouem A., Nyemeck II,Norbert Mbabi, Ndedi,Esther Del Florence Moni, Diboué,Patrick Hervé Betote, Nyegue,Maximilienne Ascension, Atchadé,Alex de Théodore, Pegnyemb,Dieudonné Emmanuel, Koert,Ulrich, Bochet,Christian G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000600739
Resumo: ABSTRACT A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[β-xylopyranosyl-(1→3)-β-glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6"-O-acetylvitexin, quercetin 3-O-β-D-glucopyranoside. The structures of those compounds and others were determined through spectral analyses. Compounds distemonanthoside, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clinical isolate strain of Mycobacterium tuberculosis AC 45; they exhibited good to moderate antitubercular activities with MIC values ranged from 31.25 to 125 µg/ml.
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spelling In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianusFabaceaeAntitubercular activityDistemonanthosideFlavonoidsPhenolic acidsABSTRACT A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[β-xylopyranosyl-(1→3)-β-glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6"-O-acetylvitexin, quercetin 3-O-β-D-glucopyranoside. The structures of those compounds and others were determined through spectral analyses. Compounds distemonanthoside, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clinical isolate strain of Mycobacterium tuberculosis AC 45; they exhibited good to moderate antitubercular activities with MIC values ranged from 31.25 to 125 µg/ml.Sociedade Brasileira de Farmacognosia2017-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000600739Revista Brasileira de Farmacognosia v.27 n.6 2017reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2017.09.006info:eu-repo/semantics/openAccessEvina,Jean NoelBikobo,Dominique Serge NgonoZintchem,Auguste Abouem A.Nyemeck II,Norbert MbabiNdedi,Esther Del Florence MoniDiboué,Patrick Hervé BetoteNyegue,Maximilienne AscensionAtchadé,Alex de ThéodorePegnyemb,Dieudonné EmmanuelKoert,UlrichBochet,Christian G.eng2018-01-08T00:00:00Zoai:scielo:S0102-695X2017000600739Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2018-01-08T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus
title In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus
spellingShingle In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus
Evina,Jean Noel
Fabaceae
Antitubercular activity
Distemonanthoside
Flavonoids
Phenolic acids
title_short In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus
title_full In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus
title_fullStr In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus
title_full_unstemmed In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus
title_sort In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus
author Evina,Jean Noel
author_facet Evina,Jean Noel
Bikobo,Dominique Serge Ngono
Zintchem,Auguste Abouem A.
Nyemeck II,Norbert Mbabi
Ndedi,Esther Del Florence Moni
Diboué,Patrick Hervé Betote
Nyegue,Maximilienne Ascension
Atchadé,Alex de Théodore
Pegnyemb,Dieudonné Emmanuel
Koert,Ulrich
Bochet,Christian G.
author_role author
author2 Bikobo,Dominique Serge Ngono
Zintchem,Auguste Abouem A.
Nyemeck II,Norbert Mbabi
Ndedi,Esther Del Florence Moni
Diboué,Patrick Hervé Betote
Nyegue,Maximilienne Ascension
Atchadé,Alex de Théodore
Pegnyemb,Dieudonné Emmanuel
Koert,Ulrich
Bochet,Christian G.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Evina,Jean Noel
Bikobo,Dominique Serge Ngono
Zintchem,Auguste Abouem A.
Nyemeck II,Norbert Mbabi
Ndedi,Esther Del Florence Moni
Diboué,Patrick Hervé Betote
Nyegue,Maximilienne Ascension
Atchadé,Alex de Théodore
Pegnyemb,Dieudonné Emmanuel
Koert,Ulrich
Bochet,Christian G.
dc.subject.por.fl_str_mv Fabaceae
Antitubercular activity
Distemonanthoside
Flavonoids
Phenolic acids
topic Fabaceae
Antitubercular activity
Distemonanthoside
Flavonoids
Phenolic acids
description ABSTRACT A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[β-xylopyranosyl-(1→3)-β-glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6"-O-acetylvitexin, quercetin 3-O-β-D-glucopyranoside. The structures of those compounds and others were determined through spectral analyses. Compounds distemonanthoside, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clinical isolate strain of Mycobacterium tuberculosis AC 45; they exhibited good to moderate antitubercular activities with MIC values ranged from 31.25 to 125 µg/ml.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000600739
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000600739
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2017.09.006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.27 n.6 2017
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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