Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats

Detalhes bibliográficos
Autor(a) principal: Duraipandiyan,Veeramuthu
Data de Publicação: 2016
Outros Autores: Al-Dhabi,Naif Abdullah, Irudayaraj,Santiagu Stephen, Sunil,Christudas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000100089
Resumo: Abstract The hypolipidemic activity of friedelin isolated from Azima tetracantha Lam., Salvadoraceae, was studied in Triton WR-1339 and high-fat diet-induced hyperlipidemic rats. In Triton WR-1339 induced hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) showed a significant (p < 0.01) lipid-lowering effect as assessed by reversal of plasma levels of total cholesterol (TC), triacylglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). In high-fat diet fed hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) caused lowering of lipid levels in plasma and liver. The hypolipidemic activity of friedelin was compared with fenofibrate, a known lipid-lowering drug, in both models.
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spelling Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic ratsFriedelinHigh-fat diet modelTriton WR-1339HyperlipidemiaFenofibrateAbstract The hypolipidemic activity of friedelin isolated from Azima tetracantha Lam., Salvadoraceae, was studied in Triton WR-1339 and high-fat diet-induced hyperlipidemic rats. In Triton WR-1339 induced hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) showed a significant (p < 0.01) lipid-lowering effect as assessed by reversal of plasma levels of total cholesterol (TC), triacylglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). In high-fat diet fed hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) caused lowering of lipid levels in plasma and liver. The hypolipidemic activity of friedelin was compared with fenofibrate, a known lipid-lowering drug, in both models.Sociedade Brasileira de Farmacognosia2016-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000100089Revista Brasileira de Farmacognosia v.26 n.1 2016reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.07.025info:eu-repo/semantics/openAccessDuraipandiyan,VeeramuthuAl-Dhabi,Naif AbdullahIrudayaraj,Santiagu StephenSunil,Christudaseng2016-02-03T00:00:00Zoai:scielo:S0102-695X2016000100089Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2016-02-03T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats
title Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats
spellingShingle Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats
Duraipandiyan,Veeramuthu
Friedelin
High-fat diet model
Triton WR-1339
Hyperlipidemia
Fenofibrate
title_short Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats
title_full Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats
title_fullStr Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats
title_full_unstemmed Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats
title_sort Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats
author Duraipandiyan,Veeramuthu
author_facet Duraipandiyan,Veeramuthu
Al-Dhabi,Naif Abdullah
Irudayaraj,Santiagu Stephen
Sunil,Christudas
author_role author
author2 Al-Dhabi,Naif Abdullah
Irudayaraj,Santiagu Stephen
Sunil,Christudas
author2_role author
author
author
dc.contributor.author.fl_str_mv Duraipandiyan,Veeramuthu
Al-Dhabi,Naif Abdullah
Irudayaraj,Santiagu Stephen
Sunil,Christudas
dc.subject.por.fl_str_mv Friedelin
High-fat diet model
Triton WR-1339
Hyperlipidemia
Fenofibrate
topic Friedelin
High-fat diet model
Triton WR-1339
Hyperlipidemia
Fenofibrate
description Abstract The hypolipidemic activity of friedelin isolated from Azima tetracantha Lam., Salvadoraceae, was studied in Triton WR-1339 and high-fat diet-induced hyperlipidemic rats. In Triton WR-1339 induced hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) showed a significant (p < 0.01) lipid-lowering effect as assessed by reversal of plasma levels of total cholesterol (TC), triacylglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). In high-fat diet fed hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) caused lowering of lipid levels in plasma and liver. The hypolipidemic activity of friedelin was compared with fenofibrate, a known lipid-lowering drug, in both models.
publishDate 2016
dc.date.none.fl_str_mv 2016-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000100089
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000100089
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2015.07.025
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.26 n.1 2016
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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