Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells

Detalhes bibliográficos
Autor(a) principal: Peláez,Guillermo L. Montoya
Data de Publicação: 2013
Outros Autores: Sierra,Jelver A., Alzate,Fernando, Holzgrabe,Ulrike, Ramirez-Pineda,José R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000500754
Resumo: Pentacyclic triterpene Natural product Cytokine modulation Anti-inflammatory activity Dendritic cells Pentacyclic triterpenes are a large family of plant metabolites that exhibit a wide array of biological activities. The genus Cecropia,which encompasses many plant species, has been used as traditional medicine for the treatment of inflammatory diseases and is known to produce many active pentacyclic triterpenes. In this study we investigated the chemical composition of a pentacyclic triterpene fraction from the roots of Cecropia telenitidaCuatrec., Urticaceae. A novel compound, which we termed yarumic acid, and four known molecules (serjanic acid, spergulagenic acid A, 20-hydroxy-ursolic acid and goreishic acid I) were isolated and characterised. In a dendritic cell (DC)based assay, we demonstrated that non-toxic doses of these pentacyclic triterpenes inhibited the secretion of at least one of the proinflammatory cytokines tested (IL-1β, IL-12p40, IL-12p70, TNF-α). Spergulagenic acid A also inhibited nitric oxide production in lipopolysaccharide-stimulated dendritic cell. Serjanic acid and spergulagenic acid A, which were the most potent abundant compounds in the pentacyclic triterpene fraction, showed the most activity in the dendritic cell-based assay. These results show that all pentacyclic triterpenes might contribute to the anti-inflammatory activities of C. telenitida. Moreover, yarumic acid as well as the four known pentacyclic triterpenes, can be exploited as potential immunomodulatory/anti-inflammatory agents.
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spelling Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cellsCecropia telenitidaPentacyclic triterpeneNatural productCytokine modulationAnti-inflammatory activityDendritic cellsPentacyclic triterpene Natural product Cytokine modulation Anti-inflammatory activity Dendritic cells Pentacyclic triterpenes are a large family of plant metabolites that exhibit a wide array of biological activities. The genus Cecropia,which encompasses many plant species, has been used as traditional medicine for the treatment of inflammatory diseases and is known to produce many active pentacyclic triterpenes. In this study we investigated the chemical composition of a pentacyclic triterpene fraction from the roots of Cecropia telenitidaCuatrec., Urticaceae. A novel compound, which we termed yarumic acid, and four known molecules (serjanic acid, spergulagenic acid A, 20-hydroxy-ursolic acid and goreishic acid I) were isolated and characterised. In a dendritic cell (DC)based assay, we demonstrated that non-toxic doses of these pentacyclic triterpenes inhibited the secretion of at least one of the proinflammatory cytokines tested (IL-1β, IL-12p40, IL-12p70, TNF-α). Spergulagenic acid A also inhibited nitric oxide production in lipopolysaccharide-stimulated dendritic cell. Serjanic acid and spergulagenic acid A, which were the most potent abundant compounds in the pentacyclic triterpene fraction, showed the most activity in the dendritic cell-based assay. These results show that all pentacyclic triterpenes might contribute to the anti-inflammatory activities of C. telenitida. Moreover, yarumic acid as well as the four known pentacyclic triterpenes, can be exploited as potential immunomodulatory/anti-inflammatory agents.Sociedade Brasileira de Farmacognosia2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000500754Revista Brasileira de Farmacognosia v.23 n.5 2013reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2013000500006info:eu-repo/semantics/openAccessPeláez,Guillermo L. MontoyaSierra,Jelver A.Alzate,FernandoHolzgrabe,UlrikeRamirez-Pineda,José R.eng2015-10-09T00:00:00Zoai:scielo:S0102-695X2013000500754Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-10-09T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells
title Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells
spellingShingle Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells
Peláez,Guillermo L. Montoya
Cecropia telenitida
Pentacyclic triterpene
Natural product
Cytokine modulation
Anti-inflammatory activity
Dendritic cells
title_short Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells
title_full Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells
title_fullStr Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells
title_full_unstemmed Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells
title_sort Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells
author Peláez,Guillermo L. Montoya
author_facet Peláez,Guillermo L. Montoya
Sierra,Jelver A.
Alzate,Fernando
Holzgrabe,Ulrike
Ramirez-Pineda,José R.
author_role author
author2 Sierra,Jelver A.
Alzate,Fernando
Holzgrabe,Ulrike
Ramirez-Pineda,José R.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Peláez,Guillermo L. Montoya
Sierra,Jelver A.
Alzate,Fernando
Holzgrabe,Ulrike
Ramirez-Pineda,José R.
dc.subject.por.fl_str_mv Cecropia telenitida
Pentacyclic triterpene
Natural product
Cytokine modulation
Anti-inflammatory activity
Dendritic cells
topic Cecropia telenitida
Pentacyclic triterpene
Natural product
Cytokine modulation
Anti-inflammatory activity
Dendritic cells
description Pentacyclic triterpene Natural product Cytokine modulation Anti-inflammatory activity Dendritic cells Pentacyclic triterpenes are a large family of plant metabolites that exhibit a wide array of biological activities. The genus Cecropia,which encompasses many plant species, has been used as traditional medicine for the treatment of inflammatory diseases and is known to produce many active pentacyclic triterpenes. In this study we investigated the chemical composition of a pentacyclic triterpene fraction from the roots of Cecropia telenitidaCuatrec., Urticaceae. A novel compound, which we termed yarumic acid, and four known molecules (serjanic acid, spergulagenic acid A, 20-hydroxy-ursolic acid and goreishic acid I) were isolated and characterised. In a dendritic cell (DC)based assay, we demonstrated that non-toxic doses of these pentacyclic triterpenes inhibited the secretion of at least one of the proinflammatory cytokines tested (IL-1β, IL-12p40, IL-12p70, TNF-α). Spergulagenic acid A also inhibited nitric oxide production in lipopolysaccharide-stimulated dendritic cell. Serjanic acid and spergulagenic acid A, which were the most potent abundant compounds in the pentacyclic triterpene fraction, showed the most activity in the dendritic cell-based assay. These results show that all pentacyclic triterpenes might contribute to the anti-inflammatory activities of C. telenitida. Moreover, yarumic acid as well as the four known pentacyclic triterpenes, can be exploited as potential immunomodulatory/anti-inflammatory agents.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000500754
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000500754
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2013000500006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.23 n.5 2013
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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