Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells

Detalhes bibliográficos
Autor(a) principal: Sousa,Grasiely Faria de
Data de Publicação: 2014
Outros Autores: Soares,Daniel Crístian Ferreira, Mussel,Wagner da Nova, Pompeu,Nana Flora Elias, Silva,Grácia Divina de Fátima, Vieira Filho,Sidney Augusto, Duarte,Lucienir Pains
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000800004
Resumo: Two new friedelane-type compounds 1 and 2 and five known pentacyclic triterpenes were isolated from branches of Maytenus robusta. Their structures were identified as 3,16-dioxo-29-hydroxyfriedelane (1), 3-oxo-16b,29-dihydroxyfriedelane (2), 3-oxofriedelane (3), 3b-friedelinol (4), 3,16-dioxofriedelane (5), 3-oxo-29-hydroxyfriedelane (6), and 3,16-dioxo-12a-hydroxyfriedelane (7). The structures and the stereochemistry of triterpenes 1 and 2 were established through infrared (IR), 1D/2D nuclear magnetic resonance (NMR), high-resolution atmospheric pressure chemical ionization mass spectrometry (HR-APCIMS) spectral data and powder X-ray diffraction. The in vitro cytotoxic property of triterpenes 1 to 6 on 4T1 murine breast cancer cells was evaluated. The triterpenes 1 and 2 showed cytotoxic activity against 4T1 cells at a lower concentration.
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spelling Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cellsMaytenus robustaCelastraceaepentacyclic triterpenesin vitro 4T1 cells cytotoxicityTwo new friedelane-type compounds 1 and 2 and five known pentacyclic triterpenes were isolated from branches of Maytenus robusta. Their structures were identified as 3,16-dioxo-29-hydroxyfriedelane (1), 3-oxo-16b,29-dihydroxyfriedelane (2), 3-oxofriedelane (3), 3b-friedelinol (4), 3,16-dioxofriedelane (5), 3-oxo-29-hydroxyfriedelane (6), and 3,16-dioxo-12a-hydroxyfriedelane (7). The structures and the stereochemistry of triterpenes 1 and 2 were established through infrared (IR), 1D/2D nuclear magnetic resonance (NMR), high-resolution atmospheric pressure chemical ionization mass spectrometry (HR-APCIMS) spectral data and powder X-ray diffraction. The in vitro cytotoxic property of triterpenes 1 to 6 on 4T1 murine breast cancer cells was evaluated. The triterpenes 1 and 2 showed cytotoxic activity against 4T1 cells at a lower concentration.Sociedade Brasileira de Química2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000800004Journal of the Brazilian Chemical Society v.25 n.8 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20140114info:eu-repo/semantics/openAccessSousa,Grasiely Faria deSoares,Daniel Crístian FerreiraMussel,Wagner da NovaPompeu,Nana Flora EliasSilva,Grácia Divina de FátimaVieira Filho,Sidney AugustoDuarte,Lucienir Painseng2014-08-04T00:00:00Zoai:scielo:S0103-50532014000800004Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-08-04T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells
title Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells
spellingShingle Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells
Sousa,Grasiely Faria de
Maytenus robusta
Celastraceae
pentacyclic triterpenes
in vitro 4T1 cells cytotoxicity
title_short Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells
title_full Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells
title_fullStr Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells
title_full_unstemmed Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells
title_sort Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells
author Sousa,Grasiely Faria de
author_facet Sousa,Grasiely Faria de
Soares,Daniel Crístian Ferreira
Mussel,Wagner da Nova
Pompeu,Nana Flora Elias
Silva,Grácia Divina de Fátima
Vieira Filho,Sidney Augusto
Duarte,Lucienir Pains
author_role author
author2 Soares,Daniel Crístian Ferreira
Mussel,Wagner da Nova
Pompeu,Nana Flora Elias
Silva,Grácia Divina de Fátima
Vieira Filho,Sidney Augusto
Duarte,Lucienir Pains
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sousa,Grasiely Faria de
Soares,Daniel Crístian Ferreira
Mussel,Wagner da Nova
Pompeu,Nana Flora Elias
Silva,Grácia Divina de Fátima
Vieira Filho,Sidney Augusto
Duarte,Lucienir Pains
dc.subject.por.fl_str_mv Maytenus robusta
Celastraceae
pentacyclic triterpenes
in vitro 4T1 cells cytotoxicity
topic Maytenus robusta
Celastraceae
pentacyclic triterpenes
in vitro 4T1 cells cytotoxicity
description Two new friedelane-type compounds 1 and 2 and five known pentacyclic triterpenes were isolated from branches of Maytenus robusta. Their structures were identified as 3,16-dioxo-29-hydroxyfriedelane (1), 3-oxo-16b,29-dihydroxyfriedelane (2), 3-oxofriedelane (3), 3b-friedelinol (4), 3,16-dioxofriedelane (5), 3-oxo-29-hydroxyfriedelane (6), and 3,16-dioxo-12a-hydroxyfriedelane (7). The structures and the stereochemistry of triterpenes 1 and 2 were established through infrared (IR), 1D/2D nuclear magnetic resonance (NMR), high-resolution atmospheric pressure chemical ionization mass spectrometry (HR-APCIMS) spectral data and powder X-ray diffraction. The in vitro cytotoxic property of triterpenes 1 to 6 on 4T1 murine breast cancer cells was evaluated. The triterpenes 1 and 2 showed cytotoxic activity against 4T1 cells at a lower concentration.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000800004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000800004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20140114
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.25 n.8 2014
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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