Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups

Detalhes bibliográficos
Autor(a) principal: Zhang,Xinju
Data de Publicação: 2018
Outros Autores: Jin,Lei, Wu,Zhiyuan, Ma,Weizhe, Chen,Yuming, Chen,Gang, Wang,Lixin, Guan,Ming
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000400578
Resumo: Abstract The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an efficient indicator of potential allopurinol hypersensitivity syndrome. In this study, rs9263726 and HLA-B*58:01 were detected in all samples. For samples of individuals whose rs9263726 genotypes were not consistent with HLA-B*58:01, we did high-resolution typing of HLA-B gene to further confirm the correlation of rs9263726 genotype and special HLA-B alleles. We confirmed that the linkage disequilibrium between rs9263726 and HLA-B*58:01 was more significant in the Han ethnic group (r2=0.886, D’=1.0) than in the Tibet and Hui ethnic groups (for Tibetan, r2=0.606, D’=0.866; for Hui, r2=0.622, D’=0.924). For Han Chinese, samples with the GG genotype of rs9263726 did not carry HLA-B*58:01, while AA genotype samples were homozygous carriers of HLA-B*58:01. However, GA genotype samples of rs9263726 required a more sophisticated HLA-B genotyping assay before it was possible to identify whether they were HLA-B*58:01 carriers or not. For Tibetan and Hui, the linkage disequilibrium between rs9263726 and HLA-B*58:01 was not significant. Therefore, rs9263726 cannot replace HLA-B*58:01 in these two groups.
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spelling Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groupsrs9263726HLA-B*58:01allopurinol hypersensitivity reactiontag SNPAbstract The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an efficient indicator of potential allopurinol hypersensitivity syndrome. In this study, rs9263726 and HLA-B*58:01 were detected in all samples. For samples of individuals whose rs9263726 genotypes were not consistent with HLA-B*58:01, we did high-resolution typing of HLA-B gene to further confirm the correlation of rs9263726 genotype and special HLA-B alleles. We confirmed that the linkage disequilibrium between rs9263726 and HLA-B*58:01 was more significant in the Han ethnic group (r2=0.886, D’=1.0) than in the Tibet and Hui ethnic groups (for Tibetan, r2=0.606, D’=0.866; for Hui, r2=0.622, D’=0.924). For Han Chinese, samples with the GG genotype of rs9263726 did not carry HLA-B*58:01, while AA genotype samples were homozygous carriers of HLA-B*58:01. However, GA genotype samples of rs9263726 required a more sophisticated HLA-B genotyping assay before it was possible to identify whether they were HLA-B*58:01 carriers or not. For Tibetan and Hui, the linkage disequilibrium between rs9263726 and HLA-B*58:01 was not significant. Therefore, rs9263726 cannot replace HLA-B*58:01 in these two groups.Sociedade Brasileira de Genética2018-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000400578Genetics and Molecular Biology v.41 n.3 2018reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2017-0258info:eu-repo/semantics/openAccessZhang,XinjuJin,LeiWu,ZhiyuanMa,WeizheChen,YumingChen,GangWang,LixinGuan,Mingeng2018-09-04T00:00:00Zoai:scielo:S1415-47572018000400578Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2018-09-04T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups
title Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups
spellingShingle Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups
Zhang,Xinju
rs9263726
HLA-B*58:01
allopurinol hypersensitivity reaction
tag SNP
title_short Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups
title_full Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups
title_fullStr Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups
title_full_unstemmed Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups
title_sort Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups
author Zhang,Xinju
author_facet Zhang,Xinju
Jin,Lei
Wu,Zhiyuan
Ma,Weizhe
Chen,Yuming
Chen,Gang
Wang,Lixin
Guan,Ming
author_role author
author2 Jin,Lei
Wu,Zhiyuan
Ma,Weizhe
Chen,Yuming
Chen,Gang
Wang,Lixin
Guan,Ming
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zhang,Xinju
Jin,Lei
Wu,Zhiyuan
Ma,Weizhe
Chen,Yuming
Chen,Gang
Wang,Lixin
Guan,Ming
dc.subject.por.fl_str_mv rs9263726
HLA-B*58:01
allopurinol hypersensitivity reaction
tag SNP
topic rs9263726
HLA-B*58:01
allopurinol hypersensitivity reaction
tag SNP
description Abstract The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an efficient indicator of potential allopurinol hypersensitivity syndrome. In this study, rs9263726 and HLA-B*58:01 were detected in all samples. For samples of individuals whose rs9263726 genotypes were not consistent with HLA-B*58:01, we did high-resolution typing of HLA-B gene to further confirm the correlation of rs9263726 genotype and special HLA-B alleles. We confirmed that the linkage disequilibrium between rs9263726 and HLA-B*58:01 was more significant in the Han ethnic group (r2=0.886, D’=1.0) than in the Tibet and Hui ethnic groups (for Tibetan, r2=0.606, D’=0.866; for Hui, r2=0.622, D’=0.924). For Han Chinese, samples with the GG genotype of rs9263726 did not carry HLA-B*58:01, while AA genotype samples were homozygous carriers of HLA-B*58:01. However, GA genotype samples of rs9263726 required a more sophisticated HLA-B genotyping assay before it was possible to identify whether they were HLA-B*58:01 carriers or not. For Tibetan and Hui, the linkage disequilibrium between rs9263726 and HLA-B*58:01 was not significant. Therefore, rs9263726 cannot replace HLA-B*58:01 in these two groups.
publishDate 2018
dc.date.none.fl_str_mv 2018-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000400578
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000400578
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4685-gmb-2017-0258
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.41 n.3 2018
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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