Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua

Detalhes bibliográficos
Autor(a) principal: Moreno,Nancy
Data de Publicação: 2002
Outros Autores: Martínez,José A., Blanco,Zorella, Osorio,Leidys, Hackshaw,Patrick
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100005
Resumo: Seven polymorphic sites in the beta-globin gene cluster were analyzed on a sample of 96 chromosomes of Venezuelan sickle cell patients from the State of Aragua. The Benin haplotype was predominant with a frequency of 0.479, followed by the Bantu haplotype (0.406); a minority of cases with other haplotypes was also identified: atypical Bantu A2 (0.042), Senegal (0.031), atypical Bantu A7 (0.021) and Saudi Arabia/Indian (0.021) haplotypes; however, the Cameroon haplotype was not identified in this study. Our results are in agreement with the historical records that establish Sudanese and Bantu origins for the African slaves brought into Venezuela.
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spelling Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of AraguahaplotypesBeta-globin gene clustersickle cellSeven polymorphic sites in the beta-globin gene cluster were analyzed on a sample of 96 chromosomes of Venezuelan sickle cell patients from the State of Aragua. The Benin haplotype was predominant with a frequency of 0.479, followed by the Bantu haplotype (0.406); a minority of cases with other haplotypes was also identified: atypical Bantu A2 (0.042), Senegal (0.031), atypical Bantu A7 (0.021) and Saudi Arabia/Indian (0.021) haplotypes; however, the Cameroon haplotype was not identified in this study. Our results are in agreement with the historical records that establish Sudanese and Bantu origins for the African slaves brought into Venezuela.Sociedade Brasileira de Genética2002-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100005Genetics and Molecular Biology v.25 n.1 2002reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572002000100005info:eu-repo/semantics/openAccessMoreno,NancyMartínez,José A.Blanco,ZorellaOsorio,LeidysHackshaw,Patrickeng2002-08-02T00:00:00Zoai:scielo:S1415-47572002000100005Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2002-08-02T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
title Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
spellingShingle Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
Moreno,Nancy
haplotypes
Beta-globin gene cluster
sickle cell
title_short Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
title_full Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
title_fullStr Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
title_full_unstemmed Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
title_sort Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
author Moreno,Nancy
author_facet Moreno,Nancy
Martínez,José A.
Blanco,Zorella
Osorio,Leidys
Hackshaw,Patrick
author_role author
author2 Martínez,José A.
Blanco,Zorella
Osorio,Leidys
Hackshaw,Patrick
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Moreno,Nancy
Martínez,José A.
Blanco,Zorella
Osorio,Leidys
Hackshaw,Patrick
dc.subject.por.fl_str_mv haplotypes
Beta-globin gene cluster
sickle cell
topic haplotypes
Beta-globin gene cluster
sickle cell
description Seven polymorphic sites in the beta-globin gene cluster were analyzed on a sample of 96 chromosomes of Venezuelan sickle cell patients from the State of Aragua. The Benin haplotype was predominant with a frequency of 0.479, followed by the Bantu haplotype (0.406); a minority of cases with other haplotypes was also identified: atypical Bantu A2 (0.042), Senegal (0.031), atypical Bantu A7 (0.021) and Saudi Arabia/Indian (0.021) haplotypes; however, the Cameroon haplotype was not identified in this study. Our results are in agreement with the historical records that establish Sudanese and Bantu origins for the African slaves brought into Venezuela.
publishDate 2002
dc.date.none.fl_str_mv 2002-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572002000100005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.25 n.1 2002
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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