Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Genetics and Molecular Biology |
| Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300009 |
Resumo: | βS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte. |
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Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazilhaplotypesβ-globinsickle-cell anemiaBrazilian populationS hemoglobinβS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte.Sociedade Brasileira de Genética2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300009Genetics and Molecular Biology v.34 n.3 2011reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572011005000027info:eu-repo/semantics/openAccessCabral,Cynthia Hatsue KitayamaSerafim,Édvis Santos SoaresMedeiros,Waleska Rayane Dantas Bezerra deFernandes,Thales Allyrio Araújo de MedeirosKimura,Elza MiyukiCosta,Fernando FerreiraSonati,Maria de FátimaRebecchi,Ivanise Marina MorettiMedeiros,Tereza Maria Dantas deeng2011-08-05T00:00:00Zoai:scielo:S1415-47572011000300009Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2011-08-05T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
| dc.title.none.fl_str_mv |
Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil |
| title |
Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil |
| spellingShingle |
Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil Cabral,Cynthia Hatsue Kitayama haplotypes β-globin sickle-cell anemia Brazilian population S hemoglobin |
| title_short |
Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil |
| title_full |
Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil |
| title_fullStr |
Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil |
| title_full_unstemmed |
Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil |
| title_sort |
Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil |
| author |
Cabral,Cynthia Hatsue Kitayama |
| author_facet |
Cabral,Cynthia Hatsue Kitayama Serafim,Édvis Santos Soares Medeiros,Waleska Rayane Dantas Bezerra de Fernandes,Thales Allyrio Araújo de Medeiros Kimura,Elza Miyuki Costa,Fernando Ferreira Sonati,Maria de Fátima Rebecchi,Ivanise Marina Moretti Medeiros,Tereza Maria Dantas de |
| author_role |
author |
| author2 |
Serafim,Édvis Santos Soares Medeiros,Waleska Rayane Dantas Bezerra de Fernandes,Thales Allyrio Araújo de Medeiros Kimura,Elza Miyuki Costa,Fernando Ferreira Sonati,Maria de Fátima Rebecchi,Ivanise Marina Moretti Medeiros,Tereza Maria Dantas de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cabral,Cynthia Hatsue Kitayama Serafim,Édvis Santos Soares Medeiros,Waleska Rayane Dantas Bezerra de Fernandes,Thales Allyrio Araújo de Medeiros Kimura,Elza Miyuki Costa,Fernando Ferreira Sonati,Maria de Fátima Rebecchi,Ivanise Marina Moretti Medeiros,Tereza Maria Dantas de |
| dc.subject.por.fl_str_mv |
haplotypes β-globin sickle-cell anemia Brazilian population S hemoglobin |
| topic |
haplotypes β-globin sickle-cell anemia Brazilian population S hemoglobin |
| description |
βS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011-01-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300009 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300009 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
10.1590/S1415-47572011005000027 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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text/html |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
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Sociedade Brasileira de Genética |
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Genetics and Molecular Biology v.34 n.3 2011 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
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Sociedade Brasileira de Genética (SBG) |
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SBG |
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SBG |
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Genetics and Molecular Biology |
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Genetics and Molecular Biology |
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Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
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||editor@gmb.org.br |
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1752122384136011776 |