Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000500501 |
Resumo: | Abstract Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role. |
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Genetics and Molecular Biology |
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Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposureCoalColombiacell cyclesystems chemo-biologyAbstract Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role.Sociedade Brasileira de Genética2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000500501Genetics and Molecular Biology v.43 n.3 2020reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2019-0134info:eu-repo/semantics/openAccessTorres-Ávila,Jose F.Espitia-Pérez,LydaBonatto,DiegoSilva,Fernanda Rabaioli daOliveira,Iuri Marques deSilva,Luís F.O.Corrêa,Dione SilvaDias,Johnny FerrazSilva,Juliana daHenriques,João Antonio Pêgaseng2020-06-24T00:00:00Zoai:scielo:S1415-47572020000500501Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2020-06-24T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
title |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
spellingShingle |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure Torres-Ávila,Jose F. Coal Colombia cell cycle systems chemo-biology |
title_short |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
title_full |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
title_fullStr |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
title_full_unstemmed |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
title_sort |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
author |
Torres-Ávila,Jose F. |
author_facet |
Torres-Ávila,Jose F. Espitia-Pérez,Lyda Bonatto,Diego Silva,Fernanda Rabaioli da Oliveira,Iuri Marques de Silva,Luís F.O. Corrêa,Dione Silva Dias,Johnny Ferraz Silva,Juliana da Henriques,João Antonio Pêgas |
author_role |
author |
author2 |
Espitia-Pérez,Lyda Bonatto,Diego Silva,Fernanda Rabaioli da Oliveira,Iuri Marques de Silva,Luís F.O. Corrêa,Dione Silva Dias,Johnny Ferraz Silva,Juliana da Henriques,João Antonio Pêgas |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Torres-Ávila,Jose F. Espitia-Pérez,Lyda Bonatto,Diego Silva,Fernanda Rabaioli da Oliveira,Iuri Marques de Silva,Luís F.O. Corrêa,Dione Silva Dias,Johnny Ferraz Silva,Juliana da Henriques,João Antonio Pêgas |
dc.subject.por.fl_str_mv |
Coal Colombia cell cycle systems chemo-biology |
topic |
Coal Colombia cell cycle systems chemo-biology |
description |
Abstract Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000500501 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000500501 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2019-0134 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.43 n.3 2020 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122390104506368 |