Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study

Detalhes bibliográficos
Autor(a) principal: Sales,Magaly M.
Data de Publicação: 1999
Outros Autores: Lucca,Edmundo J. de, Yamashita,Seizo, Saad,Luis Henrique Cury
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100004
Resumo: Human peripheral blood lymphocytes from 10 patients with familial adenomatous polyposis (FAP) showed a significantly higher incidence of chromatid breaks when compared to cells from 10 normal individuals, after exposure to bleomycin (BLM) during the G2 phase. However, no significant increase in bleomycin sensitivity was observed in lymphocytes from 10 patients with sporadic adenomatous polyps (AP) vs. 10 normal individuals (P = 0.67). Individuals that exhibited an average number of chromatid breaks per cell higher than 0.80 were considered sensitive to the drug. No control showed susceptibility to BLM, as compared to 3 out of 20 patients.
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spelling Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot studyHuman peripheral blood lymphocytes from 10 patients with familial adenomatous polyposis (FAP) showed a significantly higher incidence of chromatid breaks when compared to cells from 10 normal individuals, after exposure to bleomycin (BLM) during the G2 phase. However, no significant increase in bleomycin sensitivity was observed in lymphocytes from 10 patients with sporadic adenomatous polyps (AP) vs. 10 normal individuals (P = 0.67). Individuals that exhibited an average number of chromatid breaks per cell higher than 0.80 were considered sensitive to the drug. No control showed susceptibility to BLM, as compared to 3 out of 20 patients.Sociedade Brasileira de Genética1999-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100004Genetics and Molecular Biology v.22 n.1 1999reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47571999000100004info:eu-repo/semantics/openAccessSales,Magaly M.Lucca,Edmundo J. deYamashita,SeizoSaad,Luis Henrique Curyeng1999-06-02T00:00:00Zoai:scielo:S1415-47571999000100004Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:1999-06-02T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
title Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
spellingShingle Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
Sales,Magaly M.
title_short Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
title_full Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
title_fullStr Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
title_full_unstemmed Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
title_sort Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
author Sales,Magaly M.
author_facet Sales,Magaly M.
Lucca,Edmundo J. de
Yamashita,Seizo
Saad,Luis Henrique Cury
author_role author
author2 Lucca,Edmundo J. de
Yamashita,Seizo
Saad,Luis Henrique Cury
author2_role author
author
author
dc.contributor.author.fl_str_mv Sales,Magaly M.
Lucca,Edmundo J. de
Yamashita,Seizo
Saad,Luis Henrique Cury
description Human peripheral blood lymphocytes from 10 patients with familial adenomatous polyposis (FAP) showed a significantly higher incidence of chromatid breaks when compared to cells from 10 normal individuals, after exposure to bleomycin (BLM) during the G2 phase. However, no significant increase in bleomycin sensitivity was observed in lymphocytes from 10 patients with sporadic adenomatous polyps (AP) vs. 10 normal individuals (P = 0.67). Individuals that exhibited an average number of chromatid breaks per cell higher than 0.80 were considered sensitive to the drug. No control showed susceptibility to BLM, as compared to 3 out of 20 patients.
publishDate 1999
dc.date.none.fl_str_mv 1999-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47571999000100004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.22 n.1 1999
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
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instname_str Sociedade Brasileira de Genética (SBG)
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reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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