Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Fontes,Aparecida Maria
Data de Publicação: 2011
Outros Autores: Kashima,Simone, Bonfim-Silva,Ricardo, Azevedo,Rochele, Abraham,Kuruvilla Joseph, Albuquerque,Sérgio Roberto Lopes, Bordin,José Orlando, Langhi Júnior,Dante Mário, Covas,Dimas Tadeu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400002
Resumo: Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.
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spelling Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian AmazonBrazilian Amazon populationCR1 haplotypesKnops blood group polymorphismmalariaComplement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.Sociedade Brasileira de Genética2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400002Genetics and Molecular Biology v.34 n.4 2011reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572011005000051info:eu-repo/semantics/openAccessFontes,Aparecida MariaKashima,SimoneBonfim-Silva,RicardoAzevedo,RocheleAbraham,Kuruvilla JosephAlbuquerque,Sérgio Roberto LopesBordin,José OrlandoLanghi Júnior,Dante MárioCovas,Dimas Tadeueng2011-11-11T00:00:00Zoai:scielo:S1415-47572011000400002Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2011-11-11T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
title Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
spellingShingle Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
Fontes,Aparecida Maria
Brazilian Amazon population
CR1 haplotypes
Knops blood group polymorphism
malaria
title_short Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
title_full Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
title_fullStr Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
title_full_unstemmed Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
title_sort Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
author Fontes,Aparecida Maria
author_facet Fontes,Aparecida Maria
Kashima,Simone
Bonfim-Silva,Ricardo
Azevedo,Rochele
Abraham,Kuruvilla Joseph
Albuquerque,Sérgio Roberto Lopes
Bordin,José Orlando
Langhi Júnior,Dante Mário
Covas,Dimas Tadeu
author_role author
author2 Kashima,Simone
Bonfim-Silva,Ricardo
Azevedo,Rochele
Abraham,Kuruvilla Joseph
Albuquerque,Sérgio Roberto Lopes
Bordin,José Orlando
Langhi Júnior,Dante Mário
Covas,Dimas Tadeu
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fontes,Aparecida Maria
Kashima,Simone
Bonfim-Silva,Ricardo
Azevedo,Rochele
Abraham,Kuruvilla Joseph
Albuquerque,Sérgio Roberto Lopes
Bordin,José Orlando
Langhi Júnior,Dante Mário
Covas,Dimas Tadeu
dc.subject.por.fl_str_mv Brazilian Amazon population
CR1 haplotypes
Knops blood group polymorphism
malaria
topic Brazilian Amazon population
CR1 haplotypes
Knops blood group polymorphism
malaria
description Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572011005000051
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.34 n.4 2011
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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