Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000500743 |
Resumo: | Abstract Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors. In this study, we investigated whether SNPs in HPSE were a risk factor for hepatocellular carcinoma (HCC) by undertaking a comprehensive haplotype-tagging, case-control study. For this, six haplotype-tagging SNPs (htSNPs) in HPSE were genotyped in 400 HCC patients and 480 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. A log-additive model revealed significant correlations between the HPSE polymorphisms rs12331678 and rs12503843 and the risk of HCC in the overall samples (p = 0.0046 and p = 0.0055). When the analysis was stratified based on hepatitis B virus (HBV) carrier status, significant interactions between rs12331678 and rs12503843 and HBV were observed. Conditional logistic regression analysis for the independent effect of one significant SNP suggested that rs12331678 or rs12503843 contributed an independent effect to the significant association with the risk of HCC, respectively. Our findings suggest that the SNPs rs12331678 and rs12503843 are HCC risk factors, although the potential functional roles of these two SNPs remain to be fully elucidated. |
id |
SBG-1_2ef53dc61719d2ad44c414581c079d96 |
---|---|
oai_identifier_str |
oai:scielo:S1415-47572017000500743 |
network_acronym_str |
SBG-1 |
network_name_str |
Genetics and Molecular Biology |
repository_id_str |
|
spelling |
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populationsgenetic associationheparanasehepatocellular carcinomaHPSE genePCR-RFLPAbstract Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors. In this study, we investigated whether SNPs in HPSE were a risk factor for hepatocellular carcinoma (HCC) by undertaking a comprehensive haplotype-tagging, case-control study. For this, six haplotype-tagging SNPs (htSNPs) in HPSE were genotyped in 400 HCC patients and 480 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. A log-additive model revealed significant correlations between the HPSE polymorphisms rs12331678 and rs12503843 and the risk of HCC in the overall samples (p = 0.0046 and p = 0.0055). When the analysis was stratified based on hepatitis B virus (HBV) carrier status, significant interactions between rs12331678 and rs12503843 and HBV were observed. Conditional logistic regression analysis for the independent effect of one significant SNP suggested that rs12331678 or rs12503843 contributed an independent effect to the significant association with the risk of HCC, respectively. Our findings suggest that the SNPs rs12331678 and rs12503843 are HCC risk factors, although the potential functional roles of these two SNPs remain to be fully elucidated.Sociedade Brasileira de Genética2017-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000500743Genetics and Molecular Biology v.40 n.4 2017reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2014-0338info:eu-repo/semantics/openAccessYu,LixiaZhang,XiaoaiZhai,YunZhang,HongxingYue,WeiZhang,XiumeiWang,ZhifuZhou,HongZhou,GangqiaoGong,Fengeng2017-11-21T00:00:00Zoai:scielo:S1415-47572017000500743Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2017-11-21T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations |
title |
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations |
spellingShingle |
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations Yu,Lixia genetic association heparanase hepatocellular carcinoma HPSE gene PCR-RFLP |
title_short |
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations |
title_full |
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations |
title_fullStr |
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations |
title_full_unstemmed |
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations |
title_sort |
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations |
author |
Yu,Lixia |
author_facet |
Yu,Lixia Zhang,Xiaoai Zhai,Yun Zhang,Hongxing Yue,Wei Zhang,Xiumei Wang,Zhifu Zhou,Hong Zhou,Gangqiao Gong,Feng |
author_role |
author |
author2 |
Zhang,Xiaoai Zhai,Yun Zhang,Hongxing Yue,Wei Zhang,Xiumei Wang,Zhifu Zhou,Hong Zhou,Gangqiao Gong,Feng |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Yu,Lixia Zhang,Xiaoai Zhai,Yun Zhang,Hongxing Yue,Wei Zhang,Xiumei Wang,Zhifu Zhou,Hong Zhou,Gangqiao Gong,Feng |
dc.subject.por.fl_str_mv |
genetic association heparanase hepatocellular carcinoma HPSE gene PCR-RFLP |
topic |
genetic association heparanase hepatocellular carcinoma HPSE gene PCR-RFLP |
description |
Abstract Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors. In this study, we investigated whether SNPs in HPSE were a risk factor for hepatocellular carcinoma (HCC) by undertaking a comprehensive haplotype-tagging, case-control study. For this, six haplotype-tagging SNPs (htSNPs) in HPSE were genotyped in 400 HCC patients and 480 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. A log-additive model revealed significant correlations between the HPSE polymorphisms rs12331678 and rs12503843 and the risk of HCC in the overall samples (p = 0.0046 and p = 0.0055). When the analysis was stratified based on hepatitis B virus (HBV) carrier status, significant interactions between rs12331678 and rs12503843 and HBV were observed. Conditional logistic regression analysis for the independent effect of one significant SNP suggested that rs12331678 or rs12503843 contributed an independent effect to the significant association with the risk of HCC, respectively. Our findings suggest that the SNPs rs12331678 and rs12503843 are HCC risk factors, although the potential functional roles of these two SNPs remain to be fully elucidated. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000500743 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000500743 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2014-0338 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.40 n.4 2017 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122387643498496 |