DNA damage, oxidative stress, and inflammation in children with celiac disease
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400112 |
Resumo: | Abstract The objective of this study was to evaluate the level of genomic instability in patients with celiac disease and to establish a relationship between inflammation, oxidative stress, and DNA damage in these patients. Myeloperoxidase (MPO) activity, adenosine deaminase, nitric oxide (NOx), thiobarbituric acid, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and DNA damage were evaluated in peripheral blood samples from 47 celiac disease patients and 31 controls. Patients with celiac disease presented higher levels of DNA damage in comparison to controls (p=0.023). This difference was also observed for markers of oxidative stress, such as CAT (p=0.011) and SOD (p=0.013), and inflammatory markers such as MPO (p < 0.001) and NOx (p=0.009). Positive correlations were found between DNA damage levels and the values of CAT (r=0.405; p=0.009) and SOD (r=0.516; p < 0.001). Positive correlations were also found between GPx and NOx (r=0.349; p=0.030) and MPO and NOx (r=0.239; p=0.039). CAT and NOx showed a negative correlation (r= −0.315; p=0.042). In conclusion, intestinal inflammation can have systemic effects, causing an imbalance between oxidant and antioxidant markers, which may promote increased levels of DNA damage. |
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DNA damage, oxidative stress, and inflammation in children with celiac diseaseCeliac diseasebiochemical markersgenotoxicityreactive oxygen species (ROS)inflammatory markersAbstract The objective of this study was to evaluate the level of genomic instability in patients with celiac disease and to establish a relationship between inflammation, oxidative stress, and DNA damage in these patients. Myeloperoxidase (MPO) activity, adenosine deaminase, nitric oxide (NOx), thiobarbituric acid, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and DNA damage were evaluated in peripheral blood samples from 47 celiac disease patients and 31 controls. Patients with celiac disease presented higher levels of DNA damage in comparison to controls (p=0.023). This difference was also observed for markers of oxidative stress, such as CAT (p=0.011) and SOD (p=0.013), and inflammatory markers such as MPO (p < 0.001) and NOx (p=0.009). Positive correlations were found between DNA damage levels and the values of CAT (r=0.405; p=0.009) and SOD (r=0.516; p < 0.001). Positive correlations were also found between GPx and NOx (r=0.349; p=0.030) and MPO and NOx (r=0.239; p=0.039). CAT and NOx showed a negative correlation (r= −0.315; p=0.042). In conclusion, intestinal inflammation can have systemic effects, causing an imbalance between oxidant and antioxidant markers, which may promote increased levels of DNA damage.Sociedade Brasileira de Genética2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400112Genetics and Molecular Biology v.43 n.2 2020reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2018-0390info:eu-repo/semantics/openAccessMaluf,Sharbel WeidnerWilhelm Filho,DaniloParisotto,Eduardo BenedettiMedeiros,Guilherme da Silva dePereira,Carolina Hilgert JacobsenMaraslis,Flora TroinaDornelles Schoeller,Carlos C.Rosa,Julia Savan daFröde,Tânia Silviaeng2020-06-11T00:00:00Zoai:scielo:S1415-47572020000400112Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2020-06-11T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
DNA damage, oxidative stress, and inflammation in children with celiac disease |
title |
DNA damage, oxidative stress, and inflammation in children with celiac disease |
spellingShingle |
DNA damage, oxidative stress, and inflammation in children with celiac disease Maluf,Sharbel Weidner Celiac disease biochemical markers genotoxicity reactive oxygen species (ROS) inflammatory markers |
title_short |
DNA damage, oxidative stress, and inflammation in children with celiac disease |
title_full |
DNA damage, oxidative stress, and inflammation in children with celiac disease |
title_fullStr |
DNA damage, oxidative stress, and inflammation in children with celiac disease |
title_full_unstemmed |
DNA damage, oxidative stress, and inflammation in children with celiac disease |
title_sort |
DNA damage, oxidative stress, and inflammation in children with celiac disease |
author |
Maluf,Sharbel Weidner |
author_facet |
Maluf,Sharbel Weidner Wilhelm Filho,Danilo Parisotto,Eduardo Benedetti Medeiros,Guilherme da Silva de Pereira,Carolina Hilgert Jacobsen Maraslis,Flora Troina Dornelles Schoeller,Carlos C. Rosa,Julia Savan da Fröde,Tânia Silvia |
author_role |
author |
author2 |
Wilhelm Filho,Danilo Parisotto,Eduardo Benedetti Medeiros,Guilherme da Silva de Pereira,Carolina Hilgert Jacobsen Maraslis,Flora Troina Dornelles Schoeller,Carlos C. Rosa,Julia Savan da Fröde,Tânia Silvia |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Maluf,Sharbel Weidner Wilhelm Filho,Danilo Parisotto,Eduardo Benedetti Medeiros,Guilherme da Silva de Pereira,Carolina Hilgert Jacobsen Maraslis,Flora Troina Dornelles Schoeller,Carlos C. Rosa,Julia Savan da Fröde,Tânia Silvia |
dc.subject.por.fl_str_mv |
Celiac disease biochemical markers genotoxicity reactive oxygen species (ROS) inflammatory markers |
topic |
Celiac disease biochemical markers genotoxicity reactive oxygen species (ROS) inflammatory markers |
description |
Abstract The objective of this study was to evaluate the level of genomic instability in patients with celiac disease and to establish a relationship between inflammation, oxidative stress, and DNA damage in these patients. Myeloperoxidase (MPO) activity, adenosine deaminase, nitric oxide (NOx), thiobarbituric acid, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and DNA damage were evaluated in peripheral blood samples from 47 celiac disease patients and 31 controls. Patients with celiac disease presented higher levels of DNA damage in comparison to controls (p=0.023). This difference was also observed for markers of oxidative stress, such as CAT (p=0.011) and SOD (p=0.013), and inflammatory markers such as MPO (p < 0.001) and NOx (p=0.009). Positive correlations were found between DNA damage levels and the values of CAT (r=0.405; p=0.009) and SOD (r=0.516; p < 0.001). Positive correlations were also found between GPx and NOx (r=0.349; p=0.030) and MPO and NOx (r=0.239; p=0.039). CAT and NOx showed a negative correlation (r= −0.315; p=0.042). In conclusion, intestinal inflammation can have systemic effects, causing an imbalance between oxidant and antioxidant markers, which may promote increased levels of DNA damage. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400112 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400112 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2018-0390 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.43 n.2 2020 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122389757427712 |