Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris

Detalhes bibliográficos
Autor(a) principal: Gao,Lin
Data de Publicação: 2009
Outros Autores: Li,Hong, Li,Kai, Shen,Zhu, Liu,Ling, Li,Chunying, Zhang,Zhengdong, Liu,Yufeng
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100005
Resumo: Psoriasis vulgaris is defined by a series of linked cellular changes in the skin: hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils and other types of leukocytes in the affected skin. Catechol-O-methyltransferase ( COMT ) 158 polymorphism can reduce the activity of the COMT enzyme that may trigger defective differentiation of keratinocytes in psoriasis. Immunocytes can degrade and inactivate catecholamines via monamine oxidase (MAO) and COMT in the cells. We hypothesized that the COMT-158 G > A polymorphism was associated with the risk of psoriasis vulgaris in Han Chinese people. In a hospital-based case-control study, 524 patients with psoriasis vulgaris and 549 psoriasis-free controls were studied. COMT-158 G > A polymorphism was genotyped using the PCR sequence-specific primer (PCR-SSP) technique. We found no statistically significant association between the COMT-158 allele A and the risk of psoriasis vulgaris (p = 0.739 adjusted OR = 1.03; 95% CI = 0.81-1.31). This suggests that the COMT-158 G > A polymorphism may not contribute to the etiology of psoriasis vulgaris in the Han Chinese population.
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spelling Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris COMTgene polymorphismgenetic susceptibilitypsoriasis Psoriasis vulgaris is defined by a series of linked cellular changes in the skin: hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils and other types of leukocytes in the affected skin. Catechol-O-methyltransferase ( COMT ) 158 polymorphism can reduce the activity of the COMT enzyme that may trigger defective differentiation of keratinocytes in psoriasis. Immunocytes can degrade and inactivate catecholamines via monamine oxidase (MAO) and COMT in the cells. We hypothesized that the COMT-158 G > A polymorphism was associated with the risk of psoriasis vulgaris in Han Chinese people. In a hospital-based case-control study, 524 patients with psoriasis vulgaris and 549 psoriasis-free controls were studied. COMT-158 G > A polymorphism was genotyped using the PCR sequence-specific primer (PCR-SSP) technique. We found no statistically significant association between the COMT-158 allele A and the risk of psoriasis vulgaris (p = 0.739 adjusted OR = 1.03; 95% CI = 0.81-1.31). This suggests that the COMT-158 G > A polymorphism may not contribute to the etiology of psoriasis vulgaris in the Han Chinese population. Sociedade Brasileira de Genética2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100005Genetics and Molecular Biology v.32 n.1 2009reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572009005000002info:eu-repo/semantics/openAccessGao,LinGao,LinLi,HongLi,HongLi,KaiLi,KaiShen,ZhuLiu,LingLi,ChunyingZhang,ZhengdongLiu,Yufengeng2009-01-10T00:00:00Zoai:scielo:S1415-47572009000100005Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2009-01-10T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris
title Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris
spellingShingle Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris
Gao,Lin
COMT
gene polymorphism
genetic susceptibility
psoriasis
title_short Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris
title_full Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris
title_fullStr Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris
title_full_unstemmed Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris
title_sort Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris
author Gao,Lin
author_facet Gao,Lin
Li,Hong
Li,Kai
Shen,Zhu
Liu,Ling
Li,Chunying
Zhang,Zhengdong
Liu,Yufeng
author_role author
author2 Li,Hong
Li,Kai
Shen,Zhu
Liu,Ling
Li,Chunying
Zhang,Zhengdong
Liu,Yufeng
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gao,Lin
Gao,Lin
Li,Hong
Li,Hong
Li,Kai
Li,Kai
Shen,Zhu
Liu,Ling
Li,Chunying
Zhang,Zhengdong
Liu,Yufeng
dc.subject.por.fl_str_mv COMT
gene polymorphism
genetic susceptibility
psoriasis
topic COMT
gene polymorphism
genetic susceptibility
psoriasis
description Psoriasis vulgaris is defined by a series of linked cellular changes in the skin: hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils and other types of leukocytes in the affected skin. Catechol-O-methyltransferase ( COMT ) 158 polymorphism can reduce the activity of the COMT enzyme that may trigger defective differentiation of keratinocytes in psoriasis. Immunocytes can degrade and inactivate catecholamines via monamine oxidase (MAO) and COMT in the cells. We hypothesized that the COMT-158 G > A polymorphism was associated with the risk of psoriasis vulgaris in Han Chinese people. In a hospital-based case-control study, 524 patients with psoriasis vulgaris and 549 psoriasis-free controls were studied. COMT-158 G > A polymorphism was genotyped using the PCR sequence-specific primer (PCR-SSP) technique. We found no statistically significant association between the COMT-158 allele A and the risk of psoriasis vulgaris (p = 0.739 adjusted OR = 1.03; 95% CI = 0.81-1.31). This suggests that the COMT-158 G > A polymorphism may not contribute to the etiology of psoriasis vulgaris in the Han Chinese population.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572009005000002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.32 n.1 2009
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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