Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks

Detalhes bibliográficos
Autor(a) principal: Loreto,Elgion L.S.
Data de Publicação: 2018
Outros Autores: Deprá,Maríndia, Diesel,José F., Panzera,Yanina, Valente-Gaiesky,Vera Lucia S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200198
Resumo: Abstract Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and even-skipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks.
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spelling Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networkshobotransposable elementscis-regulatory sequencesDrosophilaAbstract Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and even-skipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks.Sociedade Brasileira de Genética2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200198Genetics and Molecular Biology v.41 n.1 suppl.1 2018reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2017-0068info:eu-repo/semantics/openAccessLoreto,Elgion L.S.Deprá,MaríndiaDiesel,José F.Panzera,YaninaValente-Gaiesky,Vera Lucia S.eng2018-04-13T00:00:00Zoai:scielo:S1415-47572018000200198Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2018-04-13T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
title Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
spellingShingle Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
Loreto,Elgion L.S.
hobo
transposable elements
cis-regulatory sequences
Drosophila
title_short Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
title_full Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
title_fullStr Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
title_full_unstemmed Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
title_sort Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
author Loreto,Elgion L.S.
author_facet Loreto,Elgion L.S.
Deprá,Maríndia
Diesel,José F.
Panzera,Yanina
Valente-Gaiesky,Vera Lucia S.
author_role author
author2 Deprá,Maríndia
Diesel,José F.
Panzera,Yanina
Valente-Gaiesky,Vera Lucia S.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Loreto,Elgion L.S.
Deprá,Maríndia
Diesel,José F.
Panzera,Yanina
Valente-Gaiesky,Vera Lucia S.
dc.subject.por.fl_str_mv hobo
transposable elements
cis-regulatory sequences
Drosophila
topic hobo
transposable elements
cis-regulatory sequences
Drosophila
description Abstract Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and even-skipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200198
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200198
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4685-gmb-2017-0068
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.41 n.1 suppl.1 2018
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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