Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks

Detalhes bibliográficos
Autor(a) principal: Loreto, Élgion Lúcio da Silva
Data de Publicação: 2018
Outros Autores: Deprá, Maríndia, Diesel, José Francisco, Panzera, Yanina, Gaiesky, Vera Lúcia da Silva Valente
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/183899
Resumo: Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and evenskipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks.
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spelling Loreto, Élgion Lúcio da SilvaDeprá, MaríndiaDiesel, José FranciscoPanzera, YaninaGaiesky, Vera Lúcia da Silva Valente2018-10-23T02:41:29Z20181415-4757http://hdl.handle.net/10183/183899001073231Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and evenskipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks.application/pdfengGenetics and molecular biology. Ribeirão Preto, SP. Vol. 41, no. 1 suppl (mar. 2018), p. 198-205.Drosophila simulansMutação genéticaFenótipohoboTransposable elementsCis-regulatory sequencesDrosophilaDrosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networksinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001073231.pdfTexto completo (inglês)application/pdf2105929http://www.lume.ufrgs.br/bitstream/10183/183899/1/001073231.pdfe9c08de03b0b55c392d723667dc2dc20MD51TEXT001073231.pdf.txt001073231.pdf.txtExtracted Texttext/plain36476http://www.lume.ufrgs.br/bitstream/10183/183899/2/001073231.pdf.txt9cd6773078feaf28c5eb7551bcf4453aMD52THUMBNAIL001073231.pdf.jpg001073231.pdf.jpgGenerated Thumbnailimage/jpeg1827http://www.lume.ufrgs.br/bitstream/10183/183899/3/001073231.pdf.jpg8ef8a01416439cd21d827cc91a9f2cc3MD5310183/1838992019-08-21 02:31:00.08673oai:www.lume.ufrgs.br:10183/183899Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-08-21T05:31Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
title Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
spellingShingle Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
Loreto, Élgion Lúcio da Silva
Drosophila simulans
Mutação genética
Fenótipo
hobo
Transposable elements
Cis-regulatory sequences
Drosophila
title_short Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
title_full Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
title_fullStr Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
title_full_unstemmed Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
title_sort Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
author Loreto, Élgion Lúcio da Silva
author_facet Loreto, Élgion Lúcio da Silva
Deprá, Maríndia
Diesel, José Francisco
Panzera, Yanina
Gaiesky, Vera Lúcia da Silva Valente
author_role author
author2 Deprá, Maríndia
Diesel, José Francisco
Panzera, Yanina
Gaiesky, Vera Lúcia da Silva Valente
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Loreto, Élgion Lúcio da Silva
Deprá, Maríndia
Diesel, José Francisco
Panzera, Yanina
Gaiesky, Vera Lúcia da Silva Valente
dc.subject.por.fl_str_mv Drosophila simulans
Mutação genética
Fenótipo
topic Drosophila simulans
Mutação genética
Fenótipo
hobo
Transposable elements
Cis-regulatory sequences
Drosophila
dc.subject.eng.fl_str_mv hobo
Transposable elements
Cis-regulatory sequences
Drosophila
description Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and evenskipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-10-23T02:41:29Z
dc.date.issued.fl_str_mv 2018
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/183899
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dc.relation.ispartof.pt_BR.fl_str_mv Genetics and molecular biology. Ribeirão Preto, SP. Vol. 41, no. 1 suppl (mar. 2018), p. 198-205.
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