Oxytocin and arginine vasopressin systems in the domestication process
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200235 |
Resumo: | Abstract Domestication is of unquestionable importance to the technological revolution that has given rise to modern human societies. In this study, we analyzed the DNA and protein sequences of six genes of the oxytocin and arginine vasopressin systems (OXT-OXTR; AVP-AVPR1a, AVPR1b and AVPR2) in 40 placental mammals. These systems play an important role in the control of physiology and behavior. According to our analyses, neutrality does not explain the pattern of molecular evolution found in some of these genes. We observed specific sites under positive selection in AVPR1b (ω = 1.429, p = 0.001) and AVPR2 (ω= 1.49, p = 0.001), suggesting that they could be involved in behavior and physiological changes, including those related to the domestication process. Furthermore, AVPR1a, which plays a role in social behavior, is under relaxed selective constraint in domesticated species. These results provide new insights into the nature of the domestication process and its impact on the OXT-AVP system. |
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Genetics and Molecular Biology |
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Oxytocin and arginine vasopressin systems in the domestication processOxytocin and receptorsvasopressin and receptorsanimal domesticationmolecular evolutionpositive selectionAbstract Domestication is of unquestionable importance to the technological revolution that has given rise to modern human societies. In this study, we analyzed the DNA and protein sequences of six genes of the oxytocin and arginine vasopressin systems (OXT-OXTR; AVP-AVPR1a, AVPR1b and AVPR2) in 40 placental mammals. These systems play an important role in the control of physiology and behavior. According to our analyses, neutrality does not explain the pattern of molecular evolution found in some of these genes. We observed specific sites under positive selection in AVPR1b (ω = 1.429, p = 0.001) and AVPR2 (ω= 1.49, p = 0.001), suggesting that they could be involved in behavior and physiological changes, including those related to the domestication process. Furthermore, AVPR1a, which plays a role in social behavior, is under relaxed selective constraint in domesticated species. These results provide new insights into the nature of the domestication process and its impact on the OXT-AVP system.Sociedade Brasileira de Genética2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200235Genetics and Molecular Biology v.41 n.1 suppl.1 2018reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2017-0069info:eu-repo/semantics/openAccessFam,Bibiana S.O.Paré,PamelaFelkl,Aline B.Vargas-Pinilla,PedroPaixão-Côrtes,Vanessa R.Viscardi,Lucas HenriquesBortolini,Maria Cátiraeng2018-04-13T00:00:00Zoai:scielo:S1415-47572018000200235Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2018-04-13T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Oxytocin and arginine vasopressin systems in the domestication process |
title |
Oxytocin and arginine vasopressin systems in the domestication process |
spellingShingle |
Oxytocin and arginine vasopressin systems in the domestication process Fam,Bibiana S.O. Oxytocin and receptors vasopressin and receptors animal domestication molecular evolution positive selection |
title_short |
Oxytocin and arginine vasopressin systems in the domestication process |
title_full |
Oxytocin and arginine vasopressin systems in the domestication process |
title_fullStr |
Oxytocin and arginine vasopressin systems in the domestication process |
title_full_unstemmed |
Oxytocin and arginine vasopressin systems in the domestication process |
title_sort |
Oxytocin and arginine vasopressin systems in the domestication process |
author |
Fam,Bibiana S.O. |
author_facet |
Fam,Bibiana S.O. Paré,Pamela Felkl,Aline B. Vargas-Pinilla,Pedro Paixão-Côrtes,Vanessa R. Viscardi,Lucas Henriques Bortolini,Maria Cátira |
author_role |
author |
author2 |
Paré,Pamela Felkl,Aline B. Vargas-Pinilla,Pedro Paixão-Côrtes,Vanessa R. Viscardi,Lucas Henriques Bortolini,Maria Cátira |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Fam,Bibiana S.O. Paré,Pamela Felkl,Aline B. Vargas-Pinilla,Pedro Paixão-Côrtes,Vanessa R. Viscardi,Lucas Henriques Bortolini,Maria Cátira |
dc.subject.por.fl_str_mv |
Oxytocin and receptors vasopressin and receptors animal domestication molecular evolution positive selection |
topic |
Oxytocin and receptors vasopressin and receptors animal domestication molecular evolution positive selection |
description |
Abstract Domestication is of unquestionable importance to the technological revolution that has given rise to modern human societies. In this study, we analyzed the DNA and protein sequences of six genes of the oxytocin and arginine vasopressin systems (OXT-OXTR; AVP-AVPR1a, AVPR1b and AVPR2) in 40 placental mammals. These systems play an important role in the control of physiology and behavior. According to our analyses, neutrality does not explain the pattern of molecular evolution found in some of these genes. We observed specific sites under positive selection in AVPR1b (ω = 1.429, p = 0.001) and AVPR2 (ω= 1.49, p = 0.001), suggesting that they could be involved in behavior and physiological changes, including those related to the domestication process. Furthermore, AVPR1a, which plays a role in social behavior, is under relaxed selective constraint in domesticated species. These results provide new insights into the nature of the domestication process and its impact on the OXT-AVP system. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200235 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200235 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2017-0069 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.41 n.1 suppl.1 2018 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122387973799936 |