Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/164631 |
Resumo: | Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits. |
id |
UFRGS-2_38b50b554373694067e9b23eed694757 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/164631 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Rosa, Pamela Laiz Paré daPaixão Côrtes, Vanessa RodriguesRodrigues, Luciana TovoVargas Pinilla, PedroViscardi, Lucas HenriquesSalzano, Francisco MauroHenkes, Luiz ErnaniBortolini, Maria Cátira2017-08-01T02:36:48Z20161415-4757http://hdl.handle.net/10183/164631001016391Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits.application/pdfengGenetics and molecular biology. Ribeirão Preto, SP. Vol. 39, no. 4, (Dec. 2016), p. 646-657OcitocinaArgininaEvolução molecularOxytocin receptorArginine vasopressin receptorsMolecular evolutionProtein disorderInteraction motifsOxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammalsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001016391.pdf001016391.pdfTexto completo (inglês)application/pdf4187895http://www.lume.ufrgs.br/bitstream/10183/164631/1/001016391.pdf8d0e61f64dbd3f3f5903ebb183ce0dbcMD51TEXT001016391.pdf.txt001016391.pdf.txtExtracted Texttext/plain49789http://www.lume.ufrgs.br/bitstream/10183/164631/2/001016391.pdf.txt37a577cace19bd53629c6c73a81694a9MD52THUMBNAIL001016391.pdf.jpg001016391.pdf.jpgGenerated Thumbnailimage/jpeg1848http://www.lume.ufrgs.br/bitstream/10183/164631/3/001016391.pdf.jpg3797323923e4eac385270a07a662f61dMD5310183/1646312019-09-29 03:45:47.137357oai:www.lume.ufrgs.br:10183/164631Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-09-29T06:45:47Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals |
title |
Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals |
spellingShingle |
Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals Rosa, Pamela Laiz Paré da Ocitocina Arginina Evolução molecular Oxytocin receptor Arginine vasopressin receptors Molecular evolution Protein disorder Interaction motifs |
title_short |
Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals |
title_full |
Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals |
title_fullStr |
Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals |
title_full_unstemmed |
Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals |
title_sort |
Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals |
author |
Rosa, Pamela Laiz Paré da |
author_facet |
Rosa, Pamela Laiz Paré da Paixão Côrtes, Vanessa Rodrigues Rodrigues, Luciana Tovo Vargas Pinilla, Pedro Viscardi, Lucas Henriques Salzano, Francisco Mauro Henkes, Luiz Ernani Bortolini, Maria Cátira |
author_role |
author |
author2 |
Paixão Côrtes, Vanessa Rodrigues Rodrigues, Luciana Tovo Vargas Pinilla, Pedro Viscardi, Lucas Henriques Salzano, Francisco Mauro Henkes, Luiz Ernani Bortolini, Maria Cátira |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Rosa, Pamela Laiz Paré da Paixão Côrtes, Vanessa Rodrigues Rodrigues, Luciana Tovo Vargas Pinilla, Pedro Viscardi, Lucas Henriques Salzano, Francisco Mauro Henkes, Luiz Ernani Bortolini, Maria Cátira |
dc.subject.por.fl_str_mv |
Ocitocina Arginina Evolução molecular |
topic |
Ocitocina Arginina Evolução molecular Oxytocin receptor Arginine vasopressin receptors Molecular evolution Protein disorder Interaction motifs |
dc.subject.eng.fl_str_mv |
Oxytocin receptor Arginine vasopressin receptors Molecular evolution Protein disorder Interaction motifs |
description |
Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-08-01T02:36:48Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/164631 |
dc.identifier.issn.pt_BR.fl_str_mv |
1415-4757 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001016391 |
identifier_str_mv |
1415-4757 001016391 |
url |
http://hdl.handle.net/10183/164631 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Genetics and molecular biology. Ribeirão Preto, SP. Vol. 39, no. 4, (Dec. 2016), p. 646-657 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/164631/1/001016391.pdf http://www.lume.ufrgs.br/bitstream/10183/164631/2/001016391.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/164631/3/001016391.pdf.jpg |
bitstream.checksum.fl_str_mv |
8d0e61f64dbd3f3f5903ebb183ce0dbc 37a577cace19bd53629c6c73a81694a9 3797323923e4eac385270a07a662f61d |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1798487350297231360 |