Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature

Detalhes bibliográficos
Autor(a) principal: Otero,Luize
Data de Publicação: 2012
Outros Autores: Souza,Daiane Correa de, Tavares,Rita de Cássia, Gomes,Bernadete Evangelho, Padilha,Telma França, Bouzas,Luiz Fernando, Fernandez,Teresa de Souza, Abdelhay,Eliana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500004
Resumo: Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.
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spelling Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literaturemonosomy 7donor cell leukemiabone marrow transplantationsevere aplastic anemiaMonosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.Sociedade Brasileira de Genética2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500004Genetics and Molecular Biology v.35 n.4 2012reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572012005000056info:eu-repo/semantics/openAccessOtero,LuizeSouza,Daiane Correa deTavares,Rita de CássiaGomes,Bernadete EvangelhoPadilha,Telma FrançaBouzas,Luiz FernandoFernandez,Teresa de SouzaAbdelhay,Elianaeng2012-12-10T00:00:00Zoai:scielo:S1415-47572012000500004Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2012-12-10T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
title Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
spellingShingle Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
Otero,Luize
monosomy 7
donor cell leukemia
bone marrow transplantation
severe aplastic anemia
title_short Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
title_full Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
title_fullStr Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
title_full_unstemmed Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
title_sort Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
author Otero,Luize
author_facet Otero,Luize
Souza,Daiane Correa de
Tavares,Rita de Cássia
Gomes,Bernadete Evangelho
Padilha,Telma França
Bouzas,Luiz Fernando
Fernandez,Teresa de Souza
Abdelhay,Eliana
author_role author
author2 Souza,Daiane Correa de
Tavares,Rita de Cássia
Gomes,Bernadete Evangelho
Padilha,Telma França
Bouzas,Luiz Fernando
Fernandez,Teresa de Souza
Abdelhay,Eliana
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Otero,Luize
Souza,Daiane Correa de
Tavares,Rita de Cássia
Gomes,Bernadete Evangelho
Padilha,Telma França
Bouzas,Luiz Fernando
Fernandez,Teresa de Souza
Abdelhay,Eliana
dc.subject.por.fl_str_mv monosomy 7
donor cell leukemia
bone marrow transplantation
severe aplastic anemia
topic monosomy 7
donor cell leukemia
bone marrow transplantation
severe aplastic anemia
description Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572012005000056
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.35 n.4 2012
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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