Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients

Detalhes bibliográficos
Autor(a) principal: Safari-Arababadi,Minoo
Data de Publicação: 2019
Outros Autores: Modarressi,Mohammad Hossein, Arababadi,Mohammad Kazemi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300337
Resumo: Abstract IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients. IPS-1 and RIP1 mRNA levels were measured in 60 CHB patients and 120 healthy subjects, using RT-qPCR technique. A significant increase in expression levels of IPS-1 and RIP1 was found in patients when compared to healthy individuals. There was no correlation between IPS-1 and RIP1expression levels with the serum levels of hepatitis B e-Antigen (HBeAg) and liver enzymes in patients. Based on the results, it seems that IPS-1 and RIP1 can participate in the induction of low chronic inflammation, which is a main cause of liver cirrhosis and hepatocellular carcinoma.
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spelling Up-regulation of RIP1 and IPS-1 in chronic HBV infected patientsInnate immunityhepatitis BRIP1IPS-1Abstract IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients. IPS-1 and RIP1 mRNA levels were measured in 60 CHB patients and 120 healthy subjects, using RT-qPCR technique. A significant increase in expression levels of IPS-1 and RIP1 was found in patients when compared to healthy individuals. There was no correlation between IPS-1 and RIP1expression levels with the serum levels of hepatitis B e-Antigen (HBeAg) and liver enzymes in patients. Based on the results, it seems that IPS-1 and RIP1 can participate in the induction of low chronic inflammation, which is a main cause of liver cirrhosis and hepatocellular carcinoma.Sociedade Brasileira de Genética2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300337Genetics and Molecular Biology v.42 n.2 2019reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2018-0071info:eu-repo/semantics/openAccessSafari-Arababadi,MinooModarressi,Mohammad HosseinArababadi,Mohammad Kazemieng2019-08-27T00:00:00Zoai:scielo:S1415-47572019000300337Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2019-08-27T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
spellingShingle Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
Safari-Arababadi,Minoo
Innate immunity
hepatitis B
RIP1
IPS-1
title_short Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title_full Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title_fullStr Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title_full_unstemmed Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title_sort Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
author Safari-Arababadi,Minoo
author_facet Safari-Arababadi,Minoo
Modarressi,Mohammad Hossein
Arababadi,Mohammad Kazemi
author_role author
author2 Modarressi,Mohammad Hossein
Arababadi,Mohammad Kazemi
author2_role author
author
dc.contributor.author.fl_str_mv Safari-Arababadi,Minoo
Modarressi,Mohammad Hossein
Arababadi,Mohammad Kazemi
dc.subject.por.fl_str_mv Innate immunity
hepatitis B
RIP1
IPS-1
topic Innate immunity
hepatitis B
RIP1
IPS-1
description Abstract IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients. IPS-1 and RIP1 mRNA levels were measured in 60 CHB patients and 120 healthy subjects, using RT-qPCR technique. A significant increase in expression levels of IPS-1 and RIP1 was found in patients when compared to healthy individuals. There was no correlation between IPS-1 and RIP1expression levels with the serum levels of hepatitis B e-Antigen (HBeAg) and liver enzymes in patients. Based on the results, it seems that IPS-1 and RIP1 can participate in the induction of low chronic inflammation, which is a main cause of liver cirrhosis and hepatocellular carcinoma.
publishDate 2019
dc.date.none.fl_str_mv 2019-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300337
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300337
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4685-gmb-2018-0071
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.42 n.2 2019
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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