Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Conti,Fátima
Data de Publicação: 1999
Outros Autores: Dal' Colletto,Glória M. Duccini, Feitosa,Mary Furlan, Krieger,Henrique
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000400004
Resumo: One hundred and seventy-seven individuals belonging to 120 complete or incomplete nuclear families from Bambui, in the State of Minas Gerais, southeastern Brazil, were studied in order to examine causes of variation in the eosinophil rate among subjects infested by intestinal worms with an extra-digestive cycle. Segregation analysis without correction for skewness showed that the hypothesis of the presence of an additive major gene was consistent with the data, although a dominant, recessive, or a multifactorial hypothesis could not account properly for the observed significant familial aggregation. The most parsimonious correction for skewness showed similar results, but could not distinguish between dominant and recessive models, although co-dominance was rejected. Since these models assume that skewness was attributable to the commingling of two distributions, these results seem to agree with those for uncorrected data. These findings suggest that several genetically independent factors determine the resistance/susceptibility to helminth infestation mainly through their ability to influence the eosinophil response.
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spelling Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern BrazilOne hundred and seventy-seven individuals belonging to 120 complete or incomplete nuclear families from Bambui, in the State of Minas Gerais, southeastern Brazil, were studied in order to examine causes of variation in the eosinophil rate among subjects infested by intestinal worms with an extra-digestive cycle. Segregation analysis without correction for skewness showed that the hypothesis of the presence of an additive major gene was consistent with the data, although a dominant, recessive, or a multifactorial hypothesis could not account properly for the observed significant familial aggregation. The most parsimonious correction for skewness showed similar results, but could not distinguish between dominant and recessive models, although co-dominance was rejected. Since these models assume that skewness was attributable to the commingling of two distributions, these results seem to agree with those for uncorrected data. These findings suggest that several genetically independent factors determine the resistance/susceptibility to helminth infestation mainly through their ability to influence the eosinophil response.Sociedade Brasileira de Genética1999-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000400004Genetics and Molecular Biology v.22 n.4 1999reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47571999000400004info:eu-repo/semantics/openAccessConti,FátimaDal' Colletto,Glória M. DucciniFeitosa,Mary FurlanKrieger,Henriqueeng2000-02-17T00:00:00Zoai:scielo:S1415-47571999000400004Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2000-02-17T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil
title Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil
spellingShingle Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil
Conti,Fátima
title_short Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil
title_full Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil
title_fullStr Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil
title_full_unstemmed Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil
title_sort Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil
author Conti,Fátima
author_facet Conti,Fátima
Dal' Colletto,Glória M. Duccini
Feitosa,Mary Furlan
Krieger,Henrique
author_role author
author2 Dal' Colletto,Glória M. Duccini
Feitosa,Mary Furlan
Krieger,Henrique
author2_role author
author
author
dc.contributor.author.fl_str_mv Conti,Fátima
Dal' Colletto,Glória M. Duccini
Feitosa,Mary Furlan
Krieger,Henrique
description One hundred and seventy-seven individuals belonging to 120 complete or incomplete nuclear families from Bambui, in the State of Minas Gerais, southeastern Brazil, were studied in order to examine causes of variation in the eosinophil rate among subjects infested by intestinal worms with an extra-digestive cycle. Segregation analysis without correction for skewness showed that the hypothesis of the presence of an additive major gene was consistent with the data, although a dominant, recessive, or a multifactorial hypothesis could not account properly for the observed significant familial aggregation. The most parsimonious correction for skewness showed similar results, but could not distinguish between dominant and recessive models, although co-dominance was rejected. Since these models assume that skewness was attributable to the commingling of two distributions, these results seem to agree with those for uncorrected data. These findings suggest that several genetically independent factors determine the resistance/susceptibility to helminth infestation mainly through their ability to influence the eosinophil response.
publishDate 1999
dc.date.none.fl_str_mv 1999-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000400004
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S1415-47571999000400004
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.22 n.4 1999
reponame:Genetics and Molecular Biology
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