Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000300113 |
Resumo: | Abstract The inclusion of a genetic risk score (GRS) can modify the risk prediction of coronary artery disease (CAD), providing an advantage over the use of traditional models. The predictive value of the genetic information on the recurrence of major adverse cardiovascular events (MACE) remains controversial. A total of 33 genetic variants previously associated with CAD were genotyped in 1587 CAD patients from the GENEMACOR study. Of these, 18 variants presented an hazard ratio >1, so they were selected to construct a weighted GRS (wGRS). MACE discrimination and reclassification were evaluated by C-Statistic, Net Reclassification Index and Integrated Discrimination Improvement methodologies. After the addition of wGRS to traditional predictors, the C-index increased from 0.566 to 0.572 (p=0.0003). Subsequently, adding wGRS to traditional plus clinical risk factors, this model slightly improved from 0.620 to 0.622 but with statistical significance (p=0.004). NRI showed that 17.9% of the cohort was better reclassified when the primary model was associated with wGRS. The Kaplan-Meier estimator showed that, at 15-year follow-up, the group with a higher number of risk alleles had a significantly higher MACE occurrence (p=0.011). In CAD patients, wGRS improved MACE risk prediction, discrimination and reclassification over the conventional factors, providing better cost-effective therapeutic strategies. |
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Genetics and Molecular Biology |
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Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR populationTraditional risk factorsgenetic risk scoreevents risk discrimination and reclassificationNet Reclassification Indexsecondary prevention of coronary artery diseaseAbstract The inclusion of a genetic risk score (GRS) can modify the risk prediction of coronary artery disease (CAD), providing an advantage over the use of traditional models. The predictive value of the genetic information on the recurrence of major adverse cardiovascular events (MACE) remains controversial. A total of 33 genetic variants previously associated with CAD were genotyped in 1587 CAD patients from the GENEMACOR study. Of these, 18 variants presented an hazard ratio >1, so they were selected to construct a weighted GRS (wGRS). MACE discrimination and reclassification were evaluated by C-Statistic, Net Reclassification Index and Integrated Discrimination Improvement methodologies. After the addition of wGRS to traditional predictors, the C-index increased from 0.566 to 0.572 (p=0.0003). Subsequently, adding wGRS to traditional plus clinical risk factors, this model slightly improved from 0.620 to 0.622 but with statistical significance (p=0.004). NRI showed that 17.9% of the cohort was better reclassified when the primary model was associated with wGRS. The Kaplan-Meier estimator showed that, at 15-year follow-up, the group with a higher number of risk alleles had a significantly higher MACE occurrence (p=0.011). In CAD patients, wGRS improved MACE risk prediction, discrimination and reclassification over the conventional factors, providing better cost-effective therapeutic strategies.Sociedade Brasileira de Genética2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000300113Genetics and Molecular Biology v.44 n.2 2021reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2020-0448info:eu-repo/semantics/openAccessMendonça,Maria IsabelHenriques,EvaBorges,SofiaSousa,Ana CéliaPereira,AndreiaSantos,MarinaTemtem,MargaridaFreitas,SóniaMonteiro,JoelSousa,João AdrianoRodrigues,RicardoGuerra,GraçaReis,Roberto Palma doseng2021-06-09T00:00:00Zoai:scielo:S1415-47572021000300113Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2021-06-09T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population |
title |
Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population |
spellingShingle |
Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population Mendonça,Maria Isabel Traditional risk factors genetic risk score events risk discrimination and reclassification Net Reclassification Index secondary prevention of coronary artery disease |
title_short |
Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population |
title_full |
Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population |
title_fullStr |
Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population |
title_full_unstemmed |
Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population |
title_sort |
Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population |
author |
Mendonça,Maria Isabel |
author_facet |
Mendonça,Maria Isabel Henriques,Eva Borges,Sofia Sousa,Ana Célia Pereira,Andreia Santos,Marina Temtem,Margarida Freitas,Sónia Monteiro,Joel Sousa,João Adriano Rodrigues,Ricardo Guerra,Graça Reis,Roberto Palma dos |
author_role |
author |
author2 |
Henriques,Eva Borges,Sofia Sousa,Ana Célia Pereira,Andreia Santos,Marina Temtem,Margarida Freitas,Sónia Monteiro,Joel Sousa,João Adriano Rodrigues,Ricardo Guerra,Graça Reis,Roberto Palma dos |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mendonça,Maria Isabel Henriques,Eva Borges,Sofia Sousa,Ana Célia Pereira,Andreia Santos,Marina Temtem,Margarida Freitas,Sónia Monteiro,Joel Sousa,João Adriano Rodrigues,Ricardo Guerra,Graça Reis,Roberto Palma dos |
dc.subject.por.fl_str_mv |
Traditional risk factors genetic risk score events risk discrimination and reclassification Net Reclassification Index secondary prevention of coronary artery disease |
topic |
Traditional risk factors genetic risk score events risk discrimination and reclassification Net Reclassification Index secondary prevention of coronary artery disease |
description |
Abstract The inclusion of a genetic risk score (GRS) can modify the risk prediction of coronary artery disease (CAD), providing an advantage over the use of traditional models. The predictive value of the genetic information on the recurrence of major adverse cardiovascular events (MACE) remains controversial. A total of 33 genetic variants previously associated with CAD were genotyped in 1587 CAD patients from the GENEMACOR study. Of these, 18 variants presented an hazard ratio >1, so they were selected to construct a weighted GRS (wGRS). MACE discrimination and reclassification were evaluated by C-Statistic, Net Reclassification Index and Integrated Discrimination Improvement methodologies. After the addition of wGRS to traditional predictors, the C-index increased from 0.566 to 0.572 (p=0.0003). Subsequently, adding wGRS to traditional plus clinical risk factors, this model slightly improved from 0.620 to 0.622 but with statistical significance (p=0.004). NRI showed that 17.9% of the cohort was better reclassified when the primary model was associated with wGRS. The Kaplan-Meier estimator showed that, at 15-year follow-up, the group with a higher number of risk alleles had a significantly higher MACE occurrence (p=0.011). In CAD patients, wGRS improved MACE risk prediction, discrimination and reclassification over the conventional factors, providing better cost-effective therapeutic strategies. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000300113 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000300113 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2020-0448 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.44 n.2 2021 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122390490382336 |