Molecular forms of butyrylcholinesterase and obesity

Detalhes bibliográficos
Autor(a) principal: Boberg,Dellyana R.
Data de Publicação: 2010
Outros Autores: Furtado-Alle,Lupe, Souza,Ricardo L.R., Chautard-Freire-Maia,Eleidi A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300011
Resumo: This study compared obese (N = 134) and unobese (N = 92) male blood donors, regarding the relative intensity (RI) and activity of different molecular forms (G1, G2, G4 and G1-ALB) of butyrylcholinesterase (BChE, EC 3.1.1.8) found in plasma, thereby searching for an association between these variables with obesity and SNPs of exons 1 and 4 of the BCHE gene. It was shown that obese and unobese individuals do not differ in the RI of each BChE band, even when classifying the sample into three genotypes of exons 1 and 4 of the BCHE gene (-116GG/539AA, -116GG/539AT, -116GA/539AT). Although the mean BChE activity of each band was significantly higher in obese than in unobese blood donors, the proportions of BChE bands were maintained, even under the metabolic stress associated to obesity, thereby leading to infer that this proportion is somehow regulated, and may therefore be important for BChE functions.
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spelling Molecular forms of butyrylcholinesterase and obesitybutyrylcholinesterasebody mass indexobesityBCHE gene SNPsThis study compared obese (N = 134) and unobese (N = 92) male blood donors, regarding the relative intensity (RI) and activity of different molecular forms (G1, G2, G4 and G1-ALB) of butyrylcholinesterase (BChE, EC 3.1.1.8) found in plasma, thereby searching for an association between these variables with obesity and SNPs of exons 1 and 4 of the BCHE gene. It was shown that obese and unobese individuals do not differ in the RI of each BChE band, even when classifying the sample into three genotypes of exons 1 and 4 of the BCHE gene (-116GG/539AA, -116GG/539AT, -116GA/539AT). Although the mean BChE activity of each band was significantly higher in obese than in unobese blood donors, the proportions of BChE bands were maintained, even under the metabolic stress associated to obesity, thereby leading to infer that this proportion is somehow regulated, and may therefore be important for BChE functions.Sociedade Brasileira de Genética2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300011Genetics and Molecular Biology v.33 n.3 2010reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572010005000072info:eu-repo/semantics/openAccessBoberg,Dellyana R.Furtado-Alle,LupeSouza,Ricardo L.R.Chautard-Freire-Maia,Eleidi A.eng2010-08-18T00:00:00Zoai:scielo:S1415-47572010000300011Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2010-08-18T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Molecular forms of butyrylcholinesterase and obesity
title Molecular forms of butyrylcholinesterase and obesity
spellingShingle Molecular forms of butyrylcholinesterase and obesity
Boberg,Dellyana R.
butyrylcholinesterase
body mass index
obesity
BCHE gene SNPs
title_short Molecular forms of butyrylcholinesterase and obesity
title_full Molecular forms of butyrylcholinesterase and obesity
title_fullStr Molecular forms of butyrylcholinesterase and obesity
title_full_unstemmed Molecular forms of butyrylcholinesterase and obesity
title_sort Molecular forms of butyrylcholinesterase and obesity
author Boberg,Dellyana R.
author_facet Boberg,Dellyana R.
Furtado-Alle,Lupe
Souza,Ricardo L.R.
Chautard-Freire-Maia,Eleidi A.
author_role author
author2 Furtado-Alle,Lupe
Souza,Ricardo L.R.
Chautard-Freire-Maia,Eleidi A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Boberg,Dellyana R.
Furtado-Alle,Lupe
Souza,Ricardo L.R.
Chautard-Freire-Maia,Eleidi A.
dc.subject.por.fl_str_mv butyrylcholinesterase
body mass index
obesity
BCHE gene SNPs
topic butyrylcholinesterase
body mass index
obesity
BCHE gene SNPs
description This study compared obese (N = 134) and unobese (N = 92) male blood donors, regarding the relative intensity (RI) and activity of different molecular forms (G1, G2, G4 and G1-ALB) of butyrylcholinesterase (BChE, EC 3.1.1.8) found in plasma, thereby searching for an association between these variables with obesity and SNPs of exons 1 and 4 of the BCHE gene. It was shown that obese and unobese individuals do not differ in the RI of each BChE band, even when classifying the sample into three genotypes of exons 1 and 4 of the BCHE gene (-116GG/539AA, -116GG/539AT, -116GA/539AT). Although the mean BChE activity of each band was significantly higher in obese than in unobese blood donors, the proportions of BChE bands were maintained, even under the metabolic stress associated to obesity, thereby leading to infer that this proportion is somehow regulated, and may therefore be important for BChE functions.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572010005000072
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.33 n.3 2010
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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