Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine

Detalhes bibliográficos
Autor(a) principal: Matos,Denise Cristina Souza
Data de Publicação: 2012
Outros Autores: Marcovistz,Rugimar, Silva,Andréa Marques Vieira da, Quintilio,Wagner, Georgini,Ricardo Amaral
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000200001
Resumo: The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibility and accuracy for potency pertussis control and this approach has been considered promising for use at least during the steps of production.
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spelling Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccineDTP vaccinePertussis whole cellenzyme-linked immunosorbent assayintracerebral mouse protection testThe aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibility and accuracy for potency pertussis control and this approach has been considered promising for use at least during the steps of production.Sociedade Brasileira de Microbiologia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000200001Brazilian Journal of Microbiology v.43 n.2 2012reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822012000200001info:eu-repo/semantics/openAccessMatos,Denise Cristina SouzaMarcovistz,RugimarSilva,Andréa Marques Vieira daQuintilio,WagnerGeorgini,Ricardo Amaraleng2012-08-07T00:00:00Zoai:scielo:S1517-83822012000200001Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2012-08-07T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
title Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
spellingShingle Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
Matos,Denise Cristina Souza
DTP vaccine
Pertussis whole cell
enzyme-linked immunosorbent assay
intracerebral mouse protection test
title_short Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
title_full Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
title_fullStr Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
title_full_unstemmed Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
title_sort Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
author Matos,Denise Cristina Souza
author_facet Matos,Denise Cristina Souza
Marcovistz,Rugimar
Silva,Andréa Marques Vieira da
Quintilio,Wagner
Georgini,Ricardo Amaral
author_role author
author2 Marcovistz,Rugimar
Silva,Andréa Marques Vieira da
Quintilio,Wagner
Georgini,Ricardo Amaral
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Matos,Denise Cristina Souza
Marcovistz,Rugimar
Silva,Andréa Marques Vieira da
Quintilio,Wagner
Georgini,Ricardo Amaral
dc.subject.por.fl_str_mv DTP vaccine
Pertussis whole cell
enzyme-linked immunosorbent assay
intracerebral mouse protection test
topic DTP vaccine
Pertussis whole cell
enzyme-linked immunosorbent assay
intracerebral mouse protection test
description The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibility and accuracy for potency pertussis control and this approach has been considered promising for use at least during the steps of production.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000200001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000200001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822012000200001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.43 n.2 2012
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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