Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Microbiology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000300009 |
Resumo: | Diclofenac sodium, an antiinflammatory agent, exhibited remarkable inhibitory action against both drug sensitive and drug resistant clinical isolates of Mycobacterium tuberculosis, as well as other mycobacteria. This drug was tested in vitro against 45 different strains of mycobacteria, most of which were inhibited by the drug at 10-25 µg/ml concentration. When tested in vivo, diclofenac, injected at 10 µg/g body weight of a Swiss strain of white mice, could significantly protect them when challenged with 50 median lethal dose of M. tuberculosis H37 Rv 102. According to chi2 test, the in vivo data were highly significant (p<0.01). Diclofenac was further tested for synergism with the conventional antimycobacterial drug streptomycin against M. smegmatis 798. When compared with their individual effects, synergism was found to be statistically significant (p<0.05). By the checkerboard assessment procedure, the fractional inhibitory concentration index of this combination was found to be 0.37, confirming synergism. |
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Brazilian Journal of Microbiology |
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Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycinantiinflammatory drugdiclofenac sodiumantimycobacterial activitystreptomycinsynergismnon-antibioticDiclofenac sodium, an antiinflammatory agent, exhibited remarkable inhibitory action against both drug sensitive and drug resistant clinical isolates of Mycobacterium tuberculosis, as well as other mycobacteria. This drug was tested in vitro against 45 different strains of mycobacteria, most of which were inhibited by the drug at 10-25 µg/ml concentration. When tested in vivo, diclofenac, injected at 10 µg/g body weight of a Swiss strain of white mice, could significantly protect them when challenged with 50 median lethal dose of M. tuberculosis H37 Rv 102. According to chi2 test, the in vivo data were highly significant (p<0.01). Diclofenac was further tested for synergism with the conventional antimycobacterial drug streptomycin against M. smegmatis 798. When compared with their individual effects, synergism was found to be statistically significant (p<0.05). By the checkerboard assessment procedure, the fractional inhibitory concentration index of this combination was found to be 0.37, confirming synergism.Sociedade Brasileira de Microbiologia2004-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000300009Brazilian Journal of Microbiology v.35 n.4 2004reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822004000300009info:eu-repo/semantics/openAccessDutta,Noton K.Dastidar,Sujata G.Kumar,AsokMazumdar,KaushikiRay,RajaChakrabarty,Atindra N.eng2005-05-23T00:00:00Zoai:scielo:S1517-83822004000300009Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2005-05-23T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false |
dc.title.none.fl_str_mv |
Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin |
title |
Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin |
spellingShingle |
Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin Dutta,Noton K. antiinflammatory drug diclofenac sodium antimycobacterial activity streptomycin synergism non-antibiotic |
title_short |
Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin |
title_full |
Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin |
title_fullStr |
Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin |
title_full_unstemmed |
Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin |
title_sort |
Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin |
author |
Dutta,Noton K. |
author_facet |
Dutta,Noton K. Dastidar,Sujata G. Kumar,Asok Mazumdar,Kaushiki Ray,Raja Chakrabarty,Atindra N. |
author_role |
author |
author2 |
Dastidar,Sujata G. Kumar,Asok Mazumdar,Kaushiki Ray,Raja Chakrabarty,Atindra N. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Dutta,Noton K. Dastidar,Sujata G. Kumar,Asok Mazumdar,Kaushiki Ray,Raja Chakrabarty,Atindra N. |
dc.subject.por.fl_str_mv |
antiinflammatory drug diclofenac sodium antimycobacterial activity streptomycin synergism non-antibiotic |
topic |
antiinflammatory drug diclofenac sodium antimycobacterial activity streptomycin synergism non-antibiotic |
description |
Diclofenac sodium, an antiinflammatory agent, exhibited remarkable inhibitory action against both drug sensitive and drug resistant clinical isolates of Mycobacterium tuberculosis, as well as other mycobacteria. This drug was tested in vitro against 45 different strains of mycobacteria, most of which were inhibited by the drug at 10-25 µg/ml concentration. When tested in vivo, diclofenac, injected at 10 µg/g body weight of a Swiss strain of white mice, could significantly protect them when challenged with 50 median lethal dose of M. tuberculosis H37 Rv 102. According to chi2 test, the in vivo data were highly significant (p<0.01). Diclofenac was further tested for synergism with the conventional antimycobacterial drug streptomycin against M. smegmatis 798. When compared with their individual effects, synergism was found to be statistically significant (p<0.05). By the checkerboard assessment procedure, the fractional inhibitory concentration index of this combination was found to be 0.37, confirming synergism. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000300009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000300009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1517-83822004000300009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Microbiology v.35 n.4 2004 reponame:Brazilian Journal of Microbiology instname:Sociedade Brasileira de Microbiologia (SBM) instacron:SBM |
instname_str |
Sociedade Brasileira de Microbiologia (SBM) |
instacron_str |
SBM |
institution |
SBM |
reponame_str |
Brazilian Journal of Microbiology |
collection |
Brazilian Journal of Microbiology |
repository.name.fl_str_mv |
Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM) |
repository.mail.fl_str_mv |
bjm@sbmicrobiologia.org.br||mbmartin@usp.br |
_version_ |
1752122200146575360 |