Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Microbiology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200336 |
Resumo: | Abstract Equine influenza is one of the major respiratory infectious diseases in horses. An equine influenza virus outbreak was identified in vaccinated and unvaccinated horses in a veterinary school hospital in São Paulo, SP, Brazil, in September 2015. The twelve equine influenza viruses isolated belonged to Florida Clade 1. The hemagglutinin and neuraminidase amino acid sequences were compared with the recent isolates from North and South America and the World Organisation for Animal Health recommended Florida Clade 1 vaccine strain. The hemagglutinin amino acid sequences had nine substitutions, compared with the vaccine strain. Two of them were in antigenic site A (A138S and G142R), one in antigenic site E (R62K) and another not in antigenic site (K304E). The four substitutions changed the hydrophobicity of hemagglutinin. Three distinct genetic variants were identified during the outbreak. Eleven variants were found in four quasispecies, which suggests the equine influenza virus evolved during the outbreak. The use of an out of date vaccine strain or updated vaccines without the production of protective antibody titers might be the major contributing factors on virus dissemination during this outbreak. |
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Brazilian Journal of Microbiology |
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Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015Equine influenzaH3N8HemagglutininNeuraminidaseEvolutionary analysisAbstract Equine influenza is one of the major respiratory infectious diseases in horses. An equine influenza virus outbreak was identified in vaccinated and unvaccinated horses in a veterinary school hospital in São Paulo, SP, Brazil, in September 2015. The twelve equine influenza viruses isolated belonged to Florida Clade 1. The hemagglutinin and neuraminidase amino acid sequences were compared with the recent isolates from North and South America and the World Organisation for Animal Health recommended Florida Clade 1 vaccine strain. The hemagglutinin amino acid sequences had nine substitutions, compared with the vaccine strain. Two of them were in antigenic site A (A138S and G142R), one in antigenic site E (R62K) and another not in antigenic site (K304E). The four substitutions changed the hydrophobicity of hemagglutinin. Three distinct genetic variants were identified during the outbreak. Eleven variants were found in four quasispecies, which suggests the equine influenza virus evolved during the outbreak. The use of an out of date vaccine strain or updated vaccines without the production of protective antibody titers might be the major contributing factors on virus dissemination during this outbreak.Sociedade Brasileira de Microbiologia2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200336Brazilian Journal of Microbiology v.49 n.2 2018reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1016/j.bjm.2017.07.003info:eu-repo/semantics/openAccessFavaro,Patricia FilippsenFernandes,Wilson RobertoReischak,DilmaraBrandão,Paulo EduardoSilva,Sheila Oliveira de SouzaRichtzenhain,Leonardo Joséeng2018-04-17T00:00:00Zoai:scielo:S1517-83822018000200336Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2018-04-17T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false |
dc.title.none.fl_str_mv |
Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015 |
title |
Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015 |
spellingShingle |
Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015 Favaro,Patricia Filippsen Equine influenza H3N8 Hemagglutinin Neuraminidase Evolutionary analysis |
title_short |
Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015 |
title_full |
Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015 |
title_fullStr |
Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015 |
title_full_unstemmed |
Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015 |
title_sort |
Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015 |
author |
Favaro,Patricia Filippsen |
author_facet |
Favaro,Patricia Filippsen Fernandes,Wilson Roberto Reischak,Dilmara Brandão,Paulo Eduardo Silva,Sheila Oliveira de Souza Richtzenhain,Leonardo José |
author_role |
author |
author2 |
Fernandes,Wilson Roberto Reischak,Dilmara Brandão,Paulo Eduardo Silva,Sheila Oliveira de Souza Richtzenhain,Leonardo José |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Favaro,Patricia Filippsen Fernandes,Wilson Roberto Reischak,Dilmara Brandão,Paulo Eduardo Silva,Sheila Oliveira de Souza Richtzenhain,Leonardo José |
dc.subject.por.fl_str_mv |
Equine influenza H3N8 Hemagglutinin Neuraminidase Evolutionary analysis |
topic |
Equine influenza H3N8 Hemagglutinin Neuraminidase Evolutionary analysis |
description |
Abstract Equine influenza is one of the major respiratory infectious diseases in horses. An equine influenza virus outbreak was identified in vaccinated and unvaccinated horses in a veterinary school hospital in São Paulo, SP, Brazil, in September 2015. The twelve equine influenza viruses isolated belonged to Florida Clade 1. The hemagglutinin and neuraminidase amino acid sequences were compared with the recent isolates from North and South America and the World Organisation for Animal Health recommended Florida Clade 1 vaccine strain. The hemagglutinin amino acid sequences had nine substitutions, compared with the vaccine strain. Two of them were in antigenic site A (A138S and G142R), one in antigenic site E (R62K) and another not in antigenic site (K304E). The four substitutions changed the hydrophobicity of hemagglutinin. Three distinct genetic variants were identified during the outbreak. Eleven variants were found in four quasispecies, which suggests the equine influenza virus evolved during the outbreak. The use of an out of date vaccine strain or updated vaccines without the production of protective antibody titers might be the major contributing factors on virus dissemination during this outbreak. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200336 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200336 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjm.2017.07.003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Microbiology v.49 n.2 2018 reponame:Brazilian Journal of Microbiology instname:Sociedade Brasileira de Microbiologia (SBM) instacron:SBM |
instname_str |
Sociedade Brasileira de Microbiologia (SBM) |
instacron_str |
SBM |
institution |
SBM |
reponame_str |
Brazilian Journal of Microbiology |
collection |
Brazilian Journal of Microbiology |
repository.name.fl_str_mv |
Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM) |
repository.mail.fl_str_mv |
bjm@sbmicrobiologia.org.br||mbmartin@usp.br |
_version_ |
1752122209618362368 |