Natural antibodies in paracoccidioidomycosis

Detalhes bibliográficos
Autor(a) principal: Unterkircher,Carmelinda S.
Data de Publicação: 2004
Outros Autores: Leão,Mariella V.P., Blotta,Maria Heloisa S.L., Camargo,Zoilo Pires de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000100009
Resumo: Recent attention has been focused on the natural antibodies as a component of natural immunity and as integral part of the idiotypic network. However, their functional role in different infections has rarely been studied. This work was undertaken to investigate the presence of natural antibodies in paracoccidioidomycosis (PCM). In addition, we analyzed anti-P. brasiliensis antibodies and their distribution in IgG subclasses in order to acquire better knowledge about the humoral immune response in this mycosis. Our findings show that the natural antibody response is not very much increased in PCM when compared with other parasite infections and this response is restricted to a few specificities, suggesting that P. brasiliensis moderately triggers CD5+ B cells. The anti-actin antibody was the main antibody specificity found in PCM. Specific antibodies to P. brasiliensis were mainly found in the IgG1 subclass in chronic patients of PCM.
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spelling Natural antibodies in paracoccidioidomycosisnatural antibodiesParacoccidioides brasiliensisparacoccidioidomycosisRecent attention has been focused on the natural antibodies as a component of natural immunity and as integral part of the idiotypic network. However, their functional role in different infections has rarely been studied. This work was undertaken to investigate the presence of natural antibodies in paracoccidioidomycosis (PCM). In addition, we analyzed anti-P. brasiliensis antibodies and their distribution in IgG subclasses in order to acquire better knowledge about the humoral immune response in this mycosis. Our findings show that the natural antibody response is not very much increased in PCM when compared with other parasite infections and this response is restricted to a few specificities, suggesting that P. brasiliensis moderately triggers CD5+ B cells. The anti-actin antibody was the main antibody specificity found in PCM. Specific antibodies to P. brasiliensis were mainly found in the IgG1 subclass in chronic patients of PCM.Sociedade Brasileira de Microbiologia2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000100009Brazilian Journal of Microbiology v.35 n.1-2 2004reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822004000100009info:eu-repo/semantics/openAccessUnterkircher,Carmelinda S.Leão,Mariella V.P.Blotta,Maria Heloisa S.L.Camargo,Zoilo Pires deeng2004-11-16T00:00:00Zoai:scielo:S1517-83822004000100009Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2004-11-16T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Natural antibodies in paracoccidioidomycosis
title Natural antibodies in paracoccidioidomycosis
spellingShingle Natural antibodies in paracoccidioidomycosis
Unterkircher,Carmelinda S.
natural antibodies
Paracoccidioides brasiliensis
paracoccidioidomycosis
title_short Natural antibodies in paracoccidioidomycosis
title_full Natural antibodies in paracoccidioidomycosis
title_fullStr Natural antibodies in paracoccidioidomycosis
title_full_unstemmed Natural antibodies in paracoccidioidomycosis
title_sort Natural antibodies in paracoccidioidomycosis
author Unterkircher,Carmelinda S.
author_facet Unterkircher,Carmelinda S.
Leão,Mariella V.P.
Blotta,Maria Heloisa S.L.
Camargo,Zoilo Pires de
author_role author
author2 Leão,Mariella V.P.
Blotta,Maria Heloisa S.L.
Camargo,Zoilo Pires de
author2_role author
author
author
dc.contributor.author.fl_str_mv Unterkircher,Carmelinda S.
Leão,Mariella V.P.
Blotta,Maria Heloisa S.L.
Camargo,Zoilo Pires de
dc.subject.por.fl_str_mv natural antibodies
Paracoccidioides brasiliensis
paracoccidioidomycosis
topic natural antibodies
Paracoccidioides brasiliensis
paracoccidioidomycosis
description Recent attention has been focused on the natural antibodies as a component of natural immunity and as integral part of the idiotypic network. However, their functional role in different infections has rarely been studied. This work was undertaken to investigate the presence of natural antibodies in paracoccidioidomycosis (PCM). In addition, we analyzed anti-P. brasiliensis antibodies and their distribution in IgG subclasses in order to acquire better knowledge about the humoral immune response in this mycosis. Our findings show that the natural antibody response is not very much increased in PCM when compared with other parasite infections and this response is restricted to a few specificities, suggesting that P. brasiliensis moderately triggers CD5+ B cells. The anti-actin antibody was the main antibody specificity found in PCM. Specific antibodies to P. brasiliensis were mainly found in the IgG1 subclass in chronic patients of PCM.
publishDate 2004
dc.date.none.fl_str_mv 2004-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000100009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000100009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822004000100009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.35 n.1-2 2004
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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