In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis

Detalhes bibliográficos
Autor(a) principal: Soares,Maria Magali Stelato Rocha
Data de Publicação: 2001
Outros Autores: Cury,Arlete Emily
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822001000200012
Resumo: The in vitro activity of antifungal and antiseptic agents were evaluated against dermatophytes isolated from patients with tinea pedis. The antifungals studied were: ciclopirox olamine, cetoconazole, tolciclate and terbinafine, and the antiseptics were: povidine iodine (PVPI), propolis, Fungol®, Andriodermol®, and boric acid. The minimum inhibitory concentration (MIC) or the minimal dilution concentration (MDC) was determined by an agar dilution method using modified yeast nitrogen agar base, and the minimum fungicidal concentration (MFC) or minimum fungicidal dilution (MFD) was determined with subcultures on Sabouraud dextrose agar. All drugs studied were active against the dermatophytes at lower concentrations than those used in products and/or pharmaceutical preparations for topical use. Some antifungal agents, mainly terbinafine and tolciclate, presented higher efficacy than the other drugs, with lower MICs and MFCs values. It was concluded that the use of these antiseptic drugs represent an excellent alternative for the topical treatment of tinea pedis. For the treatment of severe cases these are the antifungal agents of choice.
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spelling In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedisdermatophytesantifungal agentsantiseptic agentssusceptibility testingtinea pedisThe in vitro activity of antifungal and antiseptic agents were evaluated against dermatophytes isolated from patients with tinea pedis. The antifungals studied were: ciclopirox olamine, cetoconazole, tolciclate and terbinafine, and the antiseptics were: povidine iodine (PVPI), propolis, Fungol®, Andriodermol®, and boric acid. The minimum inhibitory concentration (MIC) or the minimal dilution concentration (MDC) was determined by an agar dilution method using modified yeast nitrogen agar base, and the minimum fungicidal concentration (MFC) or minimum fungicidal dilution (MFD) was determined with subcultures on Sabouraud dextrose agar. All drugs studied were active against the dermatophytes at lower concentrations than those used in products and/or pharmaceutical preparations for topical use. Some antifungal agents, mainly terbinafine and tolciclate, presented higher efficacy than the other drugs, with lower MICs and MFCs values. It was concluded that the use of these antiseptic drugs represent an excellent alternative for the topical treatment of tinea pedis. For the treatment of severe cases these are the antifungal agents of choice.Sociedade Brasileira de Microbiologia2001-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822001000200012Brazilian Journal of Microbiology v.32 n.2 2001reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822001000200012info:eu-repo/semantics/openAccessSoares,Maria Magali Stelato RochaCury,Arlete Emilyeng2001-12-12T00:00:00Zoai:scielo:S1517-83822001000200012Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2001-12-12T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis
title In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis
spellingShingle In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis
Soares,Maria Magali Stelato Rocha
dermatophytes
antifungal agents
antiseptic agents
susceptibility testing
tinea pedis
title_short In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis
title_full In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis
title_fullStr In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis
title_full_unstemmed In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis
title_sort In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis
author Soares,Maria Magali Stelato Rocha
author_facet Soares,Maria Magali Stelato Rocha
Cury,Arlete Emily
author_role author
author2 Cury,Arlete Emily
author2_role author
dc.contributor.author.fl_str_mv Soares,Maria Magali Stelato Rocha
Cury,Arlete Emily
dc.subject.por.fl_str_mv dermatophytes
antifungal agents
antiseptic agents
susceptibility testing
tinea pedis
topic dermatophytes
antifungal agents
antiseptic agents
susceptibility testing
tinea pedis
description The in vitro activity of antifungal and antiseptic agents were evaluated against dermatophytes isolated from patients with tinea pedis. The antifungals studied were: ciclopirox olamine, cetoconazole, tolciclate and terbinafine, and the antiseptics were: povidine iodine (PVPI), propolis, Fungol®, Andriodermol®, and boric acid. The minimum inhibitory concentration (MIC) or the minimal dilution concentration (MDC) was determined by an agar dilution method using modified yeast nitrogen agar base, and the minimum fungicidal concentration (MFC) or minimum fungicidal dilution (MFD) was determined with subcultures on Sabouraud dextrose agar. All drugs studied were active against the dermatophytes at lower concentrations than those used in products and/or pharmaceutical preparations for topical use. Some antifungal agents, mainly terbinafine and tolciclate, presented higher efficacy than the other drugs, with lower MICs and MFCs values. It was concluded that the use of these antiseptic drugs represent an excellent alternative for the topical treatment of tinea pedis. For the treatment of severe cases these are the antifungal agents of choice.
publishDate 2001
dc.date.none.fl_str_mv 2001-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822001000200012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822001000200012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822001000200012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.32 n.2 2001
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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