Some optimal culture conditions for production of cyclosporin a by Fusarium roseum

Detalhes bibliográficos
Autor(a) principal: Ismaiel,Ahmed A.
Data de Publicação: 2010
Outros Autores: El-Sayed,El-Sayed A., Mahmoud,Asmaa A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000400033
Resumo: A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO3, 2; KH2PO4, 1; MgSO4.7H2O, 0.5 and KCL, 0.5 (g/l). Maximum productivity of Cyc A was achieved at pH 6.0 when 50 ml of the fermentation medium/250 ml flask, inoculated with five fungal agar discs (6 mm, diameter) of 7-days old F. roseum culture after incubation at 30 ºC at 120 rpm for 7 days.
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spelling Some optimal culture conditions for production of cyclosporin a by Fusarium roseumFusarium roseumCyclosporin AFermentation conditionsA suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO3, 2; KH2PO4, 1; MgSO4.7H2O, 0.5 and KCL, 0.5 (g/l). Maximum productivity of Cyc A was achieved at pH 6.0 when 50 ml of the fermentation medium/250 ml flask, inoculated with five fungal agar discs (6 mm, diameter) of 7-days old F. roseum culture after incubation at 30 ºC at 120 rpm for 7 days.Sociedade Brasileira de Microbiologia2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000400033Brazilian Journal of Microbiology v.41 n.4 2010reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822010000400033info:eu-repo/semantics/openAccessIsmaiel,Ahmed A.El-Sayed,El-Sayed A.Mahmoud,Asmaa A.eng2010-08-09T00:00:00Zoai:scielo:S1517-83822010000400033Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2010-08-09T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
spellingShingle Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
Ismaiel,Ahmed A.
Fusarium roseum
Cyclosporin A
Fermentation conditions
title_short Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title_full Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title_fullStr Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title_full_unstemmed Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title_sort Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
author Ismaiel,Ahmed A.
author_facet Ismaiel,Ahmed A.
El-Sayed,El-Sayed A.
Mahmoud,Asmaa A.
author_role author
author2 El-Sayed,El-Sayed A.
Mahmoud,Asmaa A.
author2_role author
author
dc.contributor.author.fl_str_mv Ismaiel,Ahmed A.
El-Sayed,El-Sayed A.
Mahmoud,Asmaa A.
dc.subject.por.fl_str_mv Fusarium roseum
Cyclosporin A
Fermentation conditions
topic Fusarium roseum
Cyclosporin A
Fermentation conditions
description A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO3, 2; KH2PO4, 1; MgSO4.7H2O, 0.5 and KCL, 0.5 (g/l). Maximum productivity of Cyc A was achieved at pH 6.0 when 50 ml of the fermentation medium/250 ml flask, inoculated with five fungal agar discs (6 mm, diameter) of 7-days old F. roseum culture after incubation at 30 ºC at 120 rpm for 7 days.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000400033
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000400033
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822010000400033
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.41 n.4 2010
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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