Biopharmaceuticals from microorganisms: from production to purification

Detalhes bibliográficos
Autor(a) principal: Jozala,Angela Faustino
Data de Publicação: 2016
Outros Autores: Geraldes,Danilo Costa, Tundisi,Louise Lacalendola, Feitosa,Valker de Araújo, Breyer,Carlos Alexandre, Cardoso,Samuel Leite, Mazzola,Priscila Gava, Oliveira-Nascimento,Laura de, Rangel-Yagui,Carlota de Oliveira, Magalhães,Pérola de Oliveira, Oliveira,Marcos Antonio de, Pessoa Jr,Adalberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000500051
Resumo: ABSTRACT The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.
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spelling Biopharmaceuticals from microorganisms: from production to purificationBiopharmaceuticalsFermentation processBiotechnologyUpstream processDownstream processABSTRACT The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.Sociedade Brasileira de Microbiologia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000500051Brazilian Journal of Microbiology v.47 suppl.1 2016reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1016/j.bjm.2016.10.007info:eu-repo/semantics/openAccessJozala,Angela FaustinoGeraldes,Danilo CostaTundisi,Louise LacalendolaFeitosa,Valker de AraújoBreyer,Carlos AlexandreCardoso,Samuel LeiteMazzola,Priscila GavaOliveira-Nascimento,Laura deRangel-Yagui,Carlota de OliveiraMagalhães,Pérola de OliveiraOliveira,Marcos Antonio dePessoa Jr,Adalbertoeng2017-01-18T00:00:00Zoai:scielo:S1517-83822016000500051Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2017-01-18T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Biopharmaceuticals from microorganisms: from production to purification
title Biopharmaceuticals from microorganisms: from production to purification
spellingShingle Biopharmaceuticals from microorganisms: from production to purification
Jozala,Angela Faustino
Biopharmaceuticals
Fermentation process
Biotechnology
Upstream process
Downstream process
title_short Biopharmaceuticals from microorganisms: from production to purification
title_full Biopharmaceuticals from microorganisms: from production to purification
title_fullStr Biopharmaceuticals from microorganisms: from production to purification
title_full_unstemmed Biopharmaceuticals from microorganisms: from production to purification
title_sort Biopharmaceuticals from microorganisms: from production to purification
author Jozala,Angela Faustino
author_facet Jozala,Angela Faustino
Geraldes,Danilo Costa
Tundisi,Louise Lacalendola
Feitosa,Valker de Araújo
Breyer,Carlos Alexandre
Cardoso,Samuel Leite
Mazzola,Priscila Gava
Oliveira-Nascimento,Laura de
Rangel-Yagui,Carlota de Oliveira
Magalhães,Pérola de Oliveira
Oliveira,Marcos Antonio de
Pessoa Jr,Adalberto
author_role author
author2 Geraldes,Danilo Costa
Tundisi,Louise Lacalendola
Feitosa,Valker de Araújo
Breyer,Carlos Alexandre
Cardoso,Samuel Leite
Mazzola,Priscila Gava
Oliveira-Nascimento,Laura de
Rangel-Yagui,Carlota de Oliveira
Magalhães,Pérola de Oliveira
Oliveira,Marcos Antonio de
Pessoa Jr,Adalberto
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jozala,Angela Faustino
Geraldes,Danilo Costa
Tundisi,Louise Lacalendola
Feitosa,Valker de Araújo
Breyer,Carlos Alexandre
Cardoso,Samuel Leite
Mazzola,Priscila Gava
Oliveira-Nascimento,Laura de
Rangel-Yagui,Carlota de Oliveira
Magalhães,Pérola de Oliveira
Oliveira,Marcos Antonio de
Pessoa Jr,Adalberto
dc.subject.por.fl_str_mv Biopharmaceuticals
Fermentation process
Biotechnology
Upstream process
Downstream process
topic Biopharmaceuticals
Fermentation process
Biotechnology
Upstream process
Downstream process
description ABSTRACT The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000500051
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000500051
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjm.2016.10.007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.47 suppl.1 2016
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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