Biopharmaceuticals from microorganisms : from production to purification

• Autor(a) principal: Jozala, Angela Faustino
• Data de Publicação: 2016
• Outros Autores: Geraldes, Danilo Costa, Tundisi, Louise Lacalendola, Feitosa, Valker de Araújo, Breyer, Carlos Alexandre, Cardoso, Samuel Leite, Mazzola, Priscila Gava, Oliveira-Nascimento, Laura de, Rangel-Yagui, Carlota de Oliveira, Magalhães, Pérola de Oliveira, Oliveira, Marcos Antonio de, Pessoa Junior, Adalberto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UnB
• Texto Completo: http://repositorio.unb.br/handle/10482/30365; http://dx.doi.org/10.1016/j.bjm.2016.10.007
• topic: Biofármacos; Processo - fermentação; Biotecnologia

The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.